产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF7836, RRID:AB_2841276.
展开/折叠
AB1IP; Amyloid beta A4 precursor protein binding family B member 1 interacting protein; Amyloid beta precursor protein binding family B member 1; APBB1 interacting protein 1; INAG1; OTTHUMP00000019344; PREL 1; PREL1; Proline rich EVH1 ligand 1; Proline rich protein 73; Rap1 GTP interacting adapter molecule; RAP1 interacting adaptor molecule; RARP 1; RARP1; Retinoic acid responsive proline rich protein 1;
抗原和靶标
Widely expressed with high expression in thymus, spleen, lymph node, bone marrow and peripheral leukocytes.
- Q7Z5R6 AB1IP_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGESSEDIDQMFSTLLGEMDLLTQSLGVDTLPPPDPNPPRAEFNYSVGFKDLNESLNALEDQDLDALMADLVADISEAEQRTIQAQKESLQNQHHSASLQASIFSGAASLGYGTNVAATGISQYEDDLPPPPADPVLDLPLPPPPPEPLSQEEEEAQAKADKIKLALEKLKEAKVKKLVVKVHMNDNSTKSLMVDERQLARDVLDNLFEKTHCDCNVDWCLYEIYPELQIERFFEDHENVVEVLSDWTRDTENKILFLEKEEKYAVFKNPQNFYLDNRGKKESKETNEKMNAKNKESLLEESFCGTSIIVPELEGALYLKEDGKKSWKRRYFLLRASGIYYVPKGKTKTSRDLACFIQFENVNIYYGTQHKMKYKAPTDYCFVLKHPQIQKESQYIKYLCCDDTRTLNQWVMGIRIAKYGKTLYDNYQRAVAKAGLASRWTNLGTVNAAAPAQPSTGPKTGTTQPNGQIPQATHSVSAVLQEAQRHAETSKDKKPALGNHHDPAVPRAPHAPKSSLPPPPPVRRSSDTSGSPATPLKAKGTGGGGLPAPPDDFLPPPPPPPPLDDPELPPPPPDFMEPPPDFVPPPPPSYAGIAGSELPPPPPPPPAPAPAPVPDSARPPPAVAKRPPVPPKRQENPGHPGGAGGGEQDFMSDLMKALQKKRGNVS
翻译修饰 - Q7Z5R6 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y45 | Phosphorylation | Uniprot | |
| S55 | Phosphorylation | Uniprot | |
| K164 | Ubiquitination | Uniprot | |
| K169 | Ubiquitination | Uniprot | |
| K181 | Ubiquitination | Uniprot | |
| K190 | Ubiquitination | Uniprot | |
| K210 | Ubiquitination | Uniprot | |
| Y225 | Phosphorylation | Uniprot | |
| K254 | Ubiquitination | Uniprot | |
| K260 | Ubiquitination | Uniprot | |
| K268 | Ubiquitination | Uniprot | |
| Y274 | Phosphorylation | Uniprot | |
| Y331 | Phosphorylation | Uniprot | |
| S337 | Phosphorylation | Uniprot | |
| Y340 | Phosphorylation | Uniprot | |
| Y341 | Phosphorylation | Uniprot | |
| K375 | Ubiquitination | Uniprot | |
| Y380 | Phosphorylation | Uniprot | |
| K385 | Ubiquitination | Uniprot | |
| K391 | Ubiquitination | Uniprot | |
| K397 | Ubiquitination | Uniprot | |
| K421 | Ubiquitination | Uniprot | |
| K433 | Ubiquitination | Uniprot | |
| S525 | Phosphorylation | Uniprot | |
| S526 | Phosphorylation | Uniprot | |
| T528 | Phosphorylation | Uniprot | |
| S529 | Phosphorylation | Uniprot | |
| S531 | Phosphorylation | Uniprot | |
| T534 | Phosphorylation | Uniprot | |
| S652 | Phosphorylation | Uniprot |
研究背景
Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion.
Cell membrane>Peripheral membrane protein. Cell projection>Lamellipodium. Cell junction>Focal adhesion. Cytoplasm>Cytoskeleton.
Note: Colocalizes with ENA/VASP proteins at lamellipodia tips and focal adhesions, and F-actin at the leading edge. At the membrane surface, associates, via the PH domain, preferentially with the inositol phosphates, PtdIns(5)P and PtdIns(3)P. This binding appears to be necessary for the efficient interaction of the RA domain to Ras-GTPases (By similarity).
Widely expressed with high expression in thymus, spleen, lymph node, bone marrow and peripheral leukocytes.
Interacts, through the N-terminal Pro-rich region, with the WW domain of APBB1. Interacts with RAP1A, PFN1, TLN1, VASP, VCL and ENAH.
The two Pro-rich regions are required for the suppression of AP1 transcription activity.
Belongs to the MRL family.
研究领域
· Environmental Information Processing > Signal transduction > Rap1 signaling pathway. (View pathway)
· Organismal Systems > Immune system > Platelet activation. (View pathway)
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