产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF7861, RRID:AB_2841292.
展开/折叠
bA525O21.1 (coagulation factor XIII, A1 polypeptide); Coagulation factor XIII A chain; Coagulation factor XIII A1 polypeptide; Coagulation factor XIII A1 subunit; Coagulation factor XIII, A polypeptide; Coagulation factor XIIIa; F13A; F13A_HUMAN; F13a1; Factor XIIIA; Fibrin stabilizing factor, A subunit; Fibrinoligase; FSF, A subunit; Protein glutamine gamma glutamyltransferase A chain; Protein-glutamine gamma-glutamyltransferase A chain; TGase; Transglutaminase A chain; Transglutaminase, plasma; Transglutaminase. plasma;
抗原和靶标
- P00488 F13A_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSETSRTAFGGRRAVPPNNSNAAEDDLPTVELQGVVPRGVNLQEFLNVTSVHLFKERWDTNKVDHHTDKYENNKLIVRRGQSFYVQIDFSRPYDPRRDLFRVEYVIGRYPQENKGTYIPVPIVSELQSGKWGAKIVMREDRSVRLSIQSSPKCIVGKFRMYVAVWTPYGVLRTSRNPETDTYILFNPWCEDDAVYLDNEKEREEYVLNDIGVIFYGEVNDIKTRSWSYGQFEDGILDTCLYVMDRAQMDLSGRGNPIKVSRVGSAMVNAKDDEGVLVGSWDNIYAYGVPPSAWTGSVDILLEYRSSENPVRYGQCWVFAGVFNTFLRCLGIPARIVTNYFSAHDNDANLQMDIFLEEDGNVNSKLTKDSVWNYHCWNEAWMTRPDLPVGFGGWQAVDSTPQENSDGMYRCGPASVQAIKHGHVCFQFDAPFVFAEVNSDLIYITAKKDGTHVVENVDATHIGKLIVTKQIGGDGMMDITDTYKFQEGQEEERLALETALMYGAKKPLNTEGVMKSRSNVDMDFEVENAVLGKDFKLSITFRNNSHNRYTITAYLSANITFYTGVPKAEFKKETFDVTLEPLSFKKEAVLIQAGEYMGQLLEQASLHFFVTARINETRDVLAKQKSTVLTIPEIIIKVRGTQVVGSDMTVTVQFTNPLKETLRNVWVHLDGPGVTRPMKKMFREIRPNSTVQWEEVCRPWVSGHRKLIASMSSDSLRHVYGELDVQIQRRPSM
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P00488 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Acetylation | Uniprot | |
| Y84 | Phosphorylation | Uniprot | |
| Y104 | Phosphorylation | Uniprot | |
| Y109 | Phosphorylation | Uniprot | |
| S124 | Phosphorylation | Uniprot | |
| Y161 | Phosphorylation | Uniprot | |
| Y241 | Phosphorylation | Uniprot | |
| K584 | Acetylation | Uniprot | |
| K585 | Acetylation | Uniprot | |
| N614 | N-Glycosylation | Uniprot | |
| T640 | Phosphorylation | Uniprot | |
| S645 | Phosphorylation | Uniprot | |
| T648 | Phosphorylation | Uniprot | |
| T650 | Phosphorylation | Uniprot | |
| K678 | Acetylation | Uniprot | |
| S688 | Phosphorylation | Uniprot | |
| T689 | Phosphorylation | Uniprot | |
| S711 | Phosphorylation | Uniprot | |
| S731 | Phosphorylation | Uniprot |
研究背景
Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.
The activation peptide is released by thrombin.
Cytoplasm. Secreted.
Note: Secreted into the blood plasma. Cytoplasmic in most tissues, but also secreted in the blood plasma.
Tetramer of two A chains (F13A1) and two B (F13B) chains.
Belongs to the transglutaminase superfamily. Transglutaminase family.
研究领域
· Organismal Systems > Immune system > Complement and coagulation cascades. (View pathway)
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