INPP4A Antibody - #DF7873
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF7873, RRID:AB_2841301.
展开/折叠
107kDa; 4-bisphosphate 4-phosphatase; 9630012D15; D130048C09Rik; Inositol polyphosphate 4 phosphatase type I 107kDa; Inositol polyphosphate 4 phosphatase type I; Inositol polyphosphate 4-phosphatase type I; INP4A_HUMAN; INPP4; Inpp4a; OTTHUMP00000203138; OTTHUMP00000203139; OTTHUMP00000203141; OTTHUMP00000225217; R74740; TVAS1; Type I inositol 3 4 bisphosphate 4 phosphatase; Type I inositol 3,4 bisphosphate 4 phosphatase; Type I inositol-3;
抗原和靶标
Isoform 1 is expressed in the platelets, MEG-01 megakaryocytes and Jurkat T-cells. Isoform 2 is expressed in the brain.
- Q96PE3 INP4A_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTAREHSPRHGARARAMQRASTIDVAADMLGLSLAGNIQDPDEPILEFSLACSELHTPSLDRKPNSFVAVSVTTPPQAFWTKHAQTEIIEGTNNPIFLSSIAFFQDSLINQMTQVKLSVYDVKDRSQGTMYLLGSGTFIVKDLLQDRHHRLHLTLRSAESDRVGNITVIGWQMEEKSDQRPPVTRSVDTVNGRMVLPVDESLTEALGIRSKYASLRKDTLLKSVFGGAICRMYRFPTTDGNHLRILEQMAESVLSLHVPRQFVKLLLEEDAARVCELEELGELSPCWESLRRQIVTQYQTIILTYQENLTDLHQYRGPSFKASSLKADKKLEFVPTNLHIQRMRVQDDGGSDQNYDIVTIGAPAAHCQGFKSGGLRKKLHKFEETKKHFEECCTSSGCQSIIYIPQDVVRAKEIIAQINTLKTQVSYYAERLSRAAKDRSATGLERTLAILADKTRQLVTVCDCKLLANSIHGLNAARPDYIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLECIIQRVDKLLQKERLHGEGCEDVFPCAGSCTSKKGNPDSHAYWIRPEDPFCDVPSSPCPSTMPSTACHPHLTTHCSPPPEESSPGEWSEALYPLLTTLTDCVAMMSDKAKKAMVFLLMQDSAPTIATYLSLQYRRDVVFCQTLTALICGFIIKLRNCLHDDGFLRQLYTIGLLAQFESLLSTYGEELAMLEDMSLGIMDLRNVTFKVTQATSSASADMLPVITGNRDGFNVRVPLPGPLFDALPREIQSGMLLRVQPVLFNVGINEQQTLAERFGDTSLQEVINVESLVRLNSYFEQFKEVLPEDCLPRSRSQTCLPELLRFLGQNVHARKNKNVDILWQAAEICRRLNGVRFTSCKSAKDRTAMSVTLEQCLILQHEHGMAPQVFTQALECMRSEGCRRENTMKNVGSRKYAFNSLQLKAFPKHYRPPEGTYGKVET
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q96PE3 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S21 | Phosphorylation | Uniprot | |
| T22 | Phosphorylation | Uniprot | |
| K123 | Ubiquitination | Uniprot | |
| T137 | Phosphorylation | Uniprot | |
| R147 | Methylation | Uniprot | |
| K211 | Ubiquitination | Uniprot | |
| S214 | Phosphorylation | Uniprot | |
| T219 | Phosphorylation | Uniprot | |
| K222 | Ubiquitination | Uniprot | |
| S252 | Phosphorylation | Uniprot | |
| K321 | Methylation | Uniprot | |
| K330 | Ubiquitination | Uniprot | |
| Y355 | Phosphorylation | Uniprot | |
| K371 | Ubiquitination | Uniprot | |
| T394 | Phosphorylation | Uniprot | |
| S395 | Phosphorylation | Uniprot | |
| K412 | Ubiquitination | Uniprot | |
| Y427 | Phosphorylation | Uniprot | |
| S433 | Phosphorylation | Uniprot | |
| K454 | Ubiquitination | Uniprot | |
| K465 | Ubiquitination | Uniprot | |
| Y481 | Phosphorylation | Uniprot | |
| K485 | Ubiquitination | Uniprot | |
| S487 | Phosphorylation | Uniprot | |
| S490 | Phosphorylation | Uniprot | |
| S514 | Phosphorylation | Uniprot | |
| S517 | Phosphorylation | Uniprot | |
| K536 | Ubiquitination | Uniprot | |
| K547 | Ubiquitination | Uniprot | |
| K551 | Ubiquitination | Uniprot | |
| K745 | Ubiquitination | Uniprot | |
| S851 | Phosphorylation | Uniprot | |
| T942 | Phosphorylation | Uniprot | |
| Y951 | Phosphorylation | Uniprot | |
| S955 | Phosphorylation | Uniprot | |
| K959 | Ubiquitination | Uniprot | |
| K963 | Ubiquitination | Uniprot | |
| Y965 | Phosphorylation | Uniprot | |
| Y972 | Phosphorylation | Uniprot | |
| K974 | Ubiquitination | Uniprot |
研究背景
Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2). Catalyzes also inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate (By similarity). Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (By similarity). May protect neurons from excitotoxic cell death by regulating the synaptic localization of cell surface N-methyl-D-aspartate-type glutamate receptors (NMDARs) and NMDAR-mediated excitatory postsynaptic current (By similarity).
Displays no 4-phosphatase activity for PtdIns(3,4)P2, Ins(3,4)P2, or Ins(1,3,4)P3.
Early endosome membrane. Recycling endosome membrane. Cell membrane. Nucleus. Cytoplasm. Cell junction>Synapse>Postsynaptic density.
Note: Translocates to the plasma membrane upon EGF stimulation (PubMed:15716355). Shuttles between the cytoplasm and the nucleus, depending on the cell cycle stage, with highest amounts detected in the nucleus during the G0/G1phase (PubMed:30071275).
Isoform 1 is expressed in the platelets, MEG-01 megakaryocytes and Jurkat T-cells. Isoform 2 is expressed in the brain.
Interacts with INPP5F.
Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.
研究领域
· Environmental Information Processing > Signal transduction > Phosphatidylinositol signaling system.
· Metabolism > Carbohydrate metabolism > Inositol phosphate metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
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