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| 产品: | CITED1 抗体 |
| 货号: | DF7903 |
| 描述: | Rabbit polyclonal antibody to CITED1 |
| 应用: | WB |
| 反应: | Human |
| 分子量: | 20 kDa; 20kD(Calculated). |
| 蛋白号: | Q99966 |
| RRID: | AB_2841320 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF7903, RRID:AB_2841320.
展开/折叠
ABCC1; AI316840; AU019144; Cbp/p300-interacting transactivator 1; Cbp/p300-interacting transactivator with GLU/ASP-rich C-terminal domain, 1; Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1; CITE1_HUMAN; CITED1; melanocyte specific gene 1; Melanocyte specific protein 1; Melanocyte-specific protein 1; MSG1;
抗原和靶标
- Q99966 CITE1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPTTSRPALDVKGGTSPAKEDANQEMSSVAYSNLAVKDRKAVAILHYPGVASNGTKASGAPTSSSGSPIGSPTTTPPTKPPSFNLHPAPHLLASMHLQKLNSQYQGMAAATPGQPGEAGPLQNWDFGAQAGGAESLSPSAGAQSPAIIDSDPVDEEVLMSLVVELGLDRANELPELWLGQNEFDFTADFPSSC
翻译修饰 - Q99966 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K37 | Acetylation | Uniprot | |
| S52 | Phosphorylation | Uniprot | |
| T55 | Phosphorylation | Uniprot | |
| S64 | Phosphorylation | Uniprot |
研究背景
Transcriptional coactivator of the p300/CBP-mediated transcription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death. Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner.
Phosphorylated. Phosphorylation changes in a cell cycle-dependent manner and reduces its transcriptional coactivator activity.
Nucleus. Cytoplasm.
Note: Shuttles between the nucleus and the cytoplasm by a nuclear export signal and (NES) in a CRM1-dependent manner.
Expressed only in melanocytes and testis.
Interacts (via C-terminus) with CREBBP. Interacts with EGR2 (By similarity). Homodimer. Binds to RBM14. Interacts (via N-terminus) with HSPA8; the interaction suppresses the association of CITED1 with p300/CBP and SMAD-mediated transcription transactivation. Interacts (via C-terminus) with TOX3 (via HGM box); the interaction increases estrogen-response element (ERE)-dependent transcription and protection against cell death. Interacts with ESR1; the interaction occurs in a estrogen-dependent manner (By similarity). Interacts (unphosphorylated form preferentially and via C-terminus) with EP300.
Belongs to the CITED family.
文献引用
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