| 产品: | PCYT1A 抗体 |
| 货号: | DF7927 |
| 描述: | Rabbit polyclonal antibody to PCYT1A |
| 应用: | WB IHC |
| 反应: | Human |
| 预测: | Bovine, Horse, Sheep, Dog, Chicken, Xenopus |
| 分子量: | 42 kDa; 42kD(Calculated). |
| 蛋白号: | P49585 |
| RRID: | AB_2841339 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF7927, RRID:AB_2841339.
展开/折叠
CCT A; CCT alpha; CCT-alpha; Choline phosphate cytidylyltransferase A; Choline-phosphate cytidylyltransferase A; CT A; CT; CTP:phosphocholine cytidylyltransferase A; CTPCT; PCY1A_HUMAN; PCYT1; Pcyt1a; Phosphate cytidylyltransferase 1 choline alpha; Phosphate cytidylyltransferase 1 choline alpha isoform; Phosphorylcholine transferase A;
抗原和靶标
- P49585 PCY1A_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDAQCSAKVNARKRRKEAPGPNGATEEDGVPSKVQRCAVGLRQPAPFSDEIEVDFSKPYVRVTMEEASRGTPCERPVRVYADGIFDLFHSGHARALMQAKNLFPNTYLIVGVCSDELTHNFKGFTVMNENERYDAVQHCRYVDEVVRNAPWTLTPEFLAEHRIDFVAHDDIPYSSAGSDDVYKHIKEAGMFAPTQRTEGISTSDIITRIVRDYDVYARRNLQRGYTAKELNVSFINEKKYHLQERVDKVKKKVKDVEEKSKEFVQKVEEKSIDLIQKWEEKSREFIGSFLEMFGPEGALKHMLKEGKGRMLQAISPKQSPSSSPTRERSPSPSFRWPFSGKTSPPCSPANLSRHKAAAYDISEDEED
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P49585 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| K8 | Acetylation | Uniprot | |
| K8 | Sumoylation | Uniprot | |
| K8 | Ubiquitination | Uniprot | |
| K33 | Ubiquitination | Uniprot | |
| K57 | Acetylation | Uniprot | |
| K57 | Ubiquitination | Uniprot | |
| Y141 | Phosphorylation | Uniprot | |
| Y173 | Phosphorylation | Uniprot | |
| Y182 | Phosphorylation | Uniprot | |
| K183 | Ubiquitination | Uniprot | |
| K186 | Ubiquitination | Uniprot | |
| T197 | Phosphorylation | Uniprot | |
| Y216 | Phosphorylation | Uniprot | |
| K228 | Ubiquitination | Uniprot | |
| S233 | Phosphorylation | Uniprot | |
| K238 | Ubiquitination | Uniprot | |
| K261 | Ubiquitination | Uniprot | |
| K266 | Sumoylation | Uniprot | |
| K270 | Ubiquitination | Uniprot | |
| S271 | Phosphorylation | Uniprot | |
| K277 | Ubiquitination | Uniprot | |
| S315 | Phosphorylation | P27361 (MAPK3) , P28482 (MAPK1) | Uniprot |
| S319 | Phosphorylation | Uniprot | |
| S321 | Phosphorylation | Uniprot | |
| S322 | Phosphorylation | Uniprot | |
| S323 | Phosphorylation | Uniprot | |
| T325 | Phosphorylation | Uniprot | |
| S329 | Phosphorylation | Uniprot | |
| S331 | Phosphorylation | Uniprot | |
| S333 | Phosphorylation | Uniprot | |
| S339 | Phosphorylation | Uniprot | |
| T342 | Phosphorylation | Uniprot | |
| S343 | Phosphorylation | Uniprot | |
| S347 | Phosphorylation | Uniprot | |
| S352 | Phosphorylation | Uniprot | |
| Y359 | Phosphorylation | Uniprot | |
| S362 | Phosphorylation | Uniprot |
研究背景
Controls phosphatidylcholine synthesis.
The serine residues of the C-terminus are phosphorylated. The inactive soluble form is stabilized by phosphorylation, the active membrane bound form is promoted by anionic lipids or diacylglycerol, and is stabilized by dephosphorylation (By similarity).
Monoubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation.
Cytoplasm>Cytosol. Membrane>Peripheral membrane protein.
Note: It can interconvert between an inactive cytosolic form and an active membrane-bound form.
Homodimer.
Belongs to the cytidylyltransferase family.
研究领域
· Human Diseases > Cancers: Overview > Choline metabolism in cancer. (View pathway)
· Metabolism > Metabolism of other amino acids > Phosphonate and phosphinate metabolism.
· Metabolism > Lipid metabolism > Glycerophospholipid metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
限制条款
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