| 产品: | AGT 抗体 |
| 货号: | DF7976 |
| 描述: | Rabbit polyclonal antibody to AGT |
| 应用: | WB IHC |
| 反应: | Human, Mouse |
| 分子量: | 53 kDa; 53kD(Calculated). |
| 蛋白号: | P01019 |
| RRID: | AB_2841364 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF7976, RRID:AB_2841364.
展开/折叠
Aangiotensinogen (serpin peptidase inhibitor clade A member 8); AGT; AI265500; Alpha 1 antiproteinase antitrypsin; Ang; Ang I; Ang II; Ang III; AngII; Angiotensin I; Angiotensin II; Angiotensin III; Angiotensin-3; Angiotensinogen (PAT); Angiotensinogen; ANGT_HUMAN; ANHU; ANRT; AT-2; AT-II; Des-Asp[1]-angiotensin II; FLJ92595; FLJ97926; MGC105326; PAT; Pre angiotensinogen; Serine (or cysteine) proteinase inhibitor; Serpin A8; Serpin peptidase inhibitor clade A member 8; SERPINA8;
抗原和靶标
- P01019 ANGT_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MRKRAPQSEMAPAGVSLRATILCLLAWAGLAAGDRVYIHPFHLVIHNESTCEQLAKANAGKPKDPTFIPAPIQAKTSPVDEKALQDQLVLVAAKLDTEDKLRAAMVGMLANFLGFRIYGMHSELWGVVHGATVLSPTAVFGTLASLYLGALDHTADRLQAILGVPWKDKNCTSRLDAHKVLSALQAVQGLLVAQGRADSQAQLLLSTVVGVFTAPGLHLKQPFVQGLALYTPVVLPRSLDFTELDVAAEKIDRFMQAVTGWKTGCSLMGASVDSTLAFNTYVHFQGKMKGFSLLAEPQEFWVDNSTSVSVPMLSGMGTFQHWSDIQDNFSVTQVPFTESACLLLIQPHYASDLDKVEGLTFQQNSLNWMKKLSPRTIHLTMPQLVLQGSYDLQDLLAQAELPAILHTELNLQKLSNDRIRVGEVLNSIFFELEADEREPTESTQQLNKPEVLEVTLNRPFLFAVYDQSATALHFLGRVANPLSTA
翻译修饰 - P01019 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| N47 | N-Glycosylation | Uniprot | |
| K100 | Ubiquitination | Uniprot | |
| N170 | N-Glycosylation | Uniprot | |
| K287 | Acetylation | Uniprot | |
| N304 | N-Glycosylation | Uniprot | |
| N328 | N-Glycosylation | Uniprot |
研究背景
Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.
acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.
stimulates aldosterone release.
is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.
Beta-decarboxylation of Asp-34 in angiotensin-2, by mononuclear leukocytes produces alanine. The resulting peptide form, angiotensin-A, has the same affinity for the AT1 receptor as angiotensin-2, but a higher affinity for the AT2 receptor.
In response to low blood pressure, the enzyme renin/REN cleaves angiotensinogen to produce angiotensin-1. Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2. Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3, angiotensin-4. Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2 and can be further processed by ACE to produce angiotensin 1-7, angiotensin 1-5 and angiotensin 1-4. Angiotensin 1-7 has also been proposed to be cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin).
The disulfide bond is labile. Angiotensinogen is present in the circulation in a near 40:60 ratio with the oxidized disulfide-bonded form, which preferentially interacts with receptor-bound renin.
Secreted.
Expressed by the liver and secreted in plasma.
During pregnancy, exists as a disulfide-linked 2:2 heterotetramer with the proform of PRG2 and as a complex (probably a 2:2:2 heterohexamer) with pro-PRG2 and C3dg.
Belongs to the serpin family.
研究领域
· Organismal Systems > Endocrine system > Renin-angiotensin system. (View pathway)
· Organismal Systems > Endocrine system > Renin secretion.
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