| 产品: | RGS9 抗体 |
| 货号: | DF7979 |
| 描述: | Rabbit polyclonal antibody to RGS9 |
| 应用: | WB |
| 反应: | Human, Mouse |
| 预测: | Pig |
| 分子量: | 55 kDa; 77kD(Calculated). |
| 蛋白号: | O75916 |
| RRID: | AB_2841366 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF7979, RRID:AB_2841366.
展开/折叠
PERRS; R9AP; Regulator of G protein signalling 9; Regulator of G-protein signaling 9; RGS9; RGS9_HUMAN; RGS9L;
抗原和靶标
Highly expressed in the caudate and putamen, lower levels found in the hypothalamus and nucleus accumbens and very low levels in cerebellum. Not expressed in globus pallidus or cingulate cortex. Isoform 2 is expressed predominantly in pineal gland and retina. Isoform 3 is expressed in retina (abundant in photoreceptors).
- O75916 RGS9_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTIRHQGQQYRPRMAFLQKIEALVKDMQNPETGVRMQNQRVLVTSVPHAMTGSDVLQWIVQRLWISSLEAQNLGNFIVRYGYIYPLQDPKNLILKPDGSLYRFQTPYFWPTQQWPAEDTDYAIYLAKRNIKKKGILEEYEKENYNFLNQKMNYKWDFVIMQAKEQYRAGKERNKADRYALDCQEKAYWLVHRCPPGMDNVLDYGLDRVTNPNEVKVNQKQTVVAVKKEIMYYQQALMRSTVKSSVSLGGIVKYSEQFSSNDAIMSGCLPSNPWITDDTQFWDLNAKLVEIPTKMRVERWAFNFSELIRDPKGRQSFQYFLKKEFSGENLGFWEACEDLKYGDQSKVKEKAEEIYKLFLAPGARRWINIDGKTMDITVKGLKHPHRYVLDAAQTHIYMLMKKDSYARYLKSPIYKDMLAKAIEPQETTKKSSTLPFMRRHLRSSPSPVILRQLEEEAKAREAANTVDITQPGQHMAPSPHLTVYTGTCMPPSPSSPFSSSCRSPRKPFASPSRFIRRPSTTICPSPIRVALESSSGLEQKGECSGSMAPRGPSVTESSEASLDTSWPRSRPRAPPKARMALSFSRFLRRGCLASPVFARLSPKCPAVSHGRVQPLGDVGQQLPRLKSKRVANFFQIKMDVPTGSGTCLMDSEDAGTGESGDRATEKEVICPWESL
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - O75916 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S66 | Phosphorylation | Uniprot | |
| K141 | Acetylation | Uniprot | |
| K141 | Ubiquitination | Uniprot | |
| Y153 | Phosphorylation | Uniprot | |
| K185 | Ubiquitination | Uniprot | |
| S304 | Phosphorylation | Uniprot | |
| K409 | Ubiquitination | Uniprot | |
| K419 | Acetylation | Uniprot | |
| S445 | Phosphorylation | Uniprot | |
| S545 | Phosphorylation | Uniprot | |
| S556 | Phosphorylation | Uniprot | |
| T563 | Phosphorylation | Uniprot | |
| S564 | Phosphorylation | Uniprot | |
| S568 | Phosphorylation | Uniprot |
研究背景
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to GNAT1. Involved in phototransduction; key element in the recovery phase of visual transduction (By similarity).
Retinal isoform 3 is light-dependent phosphorylated at 'Ser-478'. Phosphorylation is decreased by light exposition (By similarity).
Membrane>Peripheral membrane protein.
Note: Isoform 3 is targeted to the membrane via its interaction with RGS9BP.
Highly expressed in the caudate and putamen, lower levels found in the hypothalamus and nucleus accumbens and very low levels in cerebellum. Not expressed in globus pallidus or cingulate cortex. Isoform 2 is expressed predominantly in pineal gland and retina. Isoform 3 is expressed in retina (abundant in photoreceptors).
Heterodimer with GNB5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with GNB5. Component of the RGS9-1-Gbeta5 complex composed of RGS9 (RGS9-1), Gbeta5 (GNB5) and RGS9BP. Interacts with PDE6G and GNAT1.
In photoreceptor cells the DEP domain is essential for targeting RGS9 to the outer rod segments.
研究领域
· Human Diseases > Substance dependence > Cocaine addiction.
· Organismal Systems > Sensory system > Phototransduction.
限制条款
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