| 产品: | FSCN1 抗体 |
| 货号: | DF7988 |
| 描述: | Rabbit polyclonal antibody to FSCN1 |
| 应用: | WB IHC |
| 反应: | Human, Mouse |
| 预测: | Pig, Bovine, Horse, Sheep, Dog, Chicken |
| 分子量: | 54 kDa; 55kD(Calculated). |
| 蛋白号: | Q16658 |
| RRID: | AB_2841372 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF7988, RRID:AB_2841372.
展开/折叠
55 kDa actin bundling protein; 55 kDa actin-bundling protein; Actin bundling protein; actin bundling protein, 55-KD; FAN 1; FAN1; Fascin 1; Fascin actin bundling protein 1; Fascin; Fascin homolog 1 actin bundling protein (Strongylocentrotus purpuratus); Fascin homolog 1; Fascin, sea urchin, homolog of, 1; Fascin1; FLJ38511; FSCN 1; FSCN1; FSCN1_HUMAN; HSN; p55; Singed (Drosophila) like (sea urchin fascin homolog like); Singed drosophila homolog like; Singed like (fascin homolog sea urchin) (Drosophila); Singed like (fascin homolog sea urchin); Singed like protein; Singed, drosophila, homolog of; Singed-like protein; SNL; Strongylocentrotus purpuratus;
抗原和靶标
- Q16658 FSCN1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTANGTAEAVQIQFGLINCGNKYLTAEAFGFKVNASASSLKKKQIWTLEQPPDEAGSAAVCLRSHLGRYLAADKDGNVTCEREVPGPDCRFLIVAHDDGRWSLQSEAHRRYFGGTEDRLSCFAQTVSPAEKWSVHIAMHPQVNIYSVTRKRYAHLSARPADEIAVDRDVPWGVDSLITLAFQDQRYSVQTADHRFLRHDGRLVARPEPATGYTLEFRSGKVAFRDCEGRYLAPSGPSGTLKAGKATKVGKDELFALEQSCAQVVLQAANERNVSTRQGMDLSANQDEETDQETFQLEIDRDTKKCAFRTHTGKYWTLTATGGVQSTASSKNASCYFDIEWRDRRITLRASNGKFVTSKKNGQLAASVETAGDSELFLMKLINRPIIVFRGEHGFIGCRKVTGTLDANRSSYDVFQLEFNDGAYNIKDSTGKYWTVGSDSAVTSSGDTPVDFFFEFCDYNKVAIKVGGRYLKGDHAGVLKASAETVDPASLWEY
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q16658 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T2 | Acetylation | Uniprot | |
| Y23 | Phosphorylation | Uniprot | |
| S38 | Phosphorylation | Uniprot | |
| S39 | Phosphorylation | P17252 (PRKCA) , Q05655 (PRKCD) | Uniprot |
| K41 | Acetylation | Uniprot | |
| K41 | Ubiquitination | Uniprot | |
| K42 | Ubiquitination | Uniprot | |
| K43 | Acetylation | Uniprot | |
| K43 | Ubiquitination | Uniprot | |
| Y69 | Phosphorylation | Uniprot | |
| K74 | Acetylation | Uniprot | |
| K74 | Ubiquitination | Uniprot | |
| T79 | Phosphorylation | Uniprot | |
| C80 | S-Nitrosylation | Uniprot | |
| R118 | Methylation | Uniprot | |
| S120 | Phosphorylation | Uniprot | |
| S127 | Phosphorylation | Uniprot | |
| Y145 | Phosphorylation | Uniprot | |
| S146 | Phosphorylation | Uniprot | |
| T148 | Phosphorylation | Uniprot | |
| R217 | Methylation | Uniprot | |
| S218 | Phosphorylation | Uniprot | |
| S234 | Phosphorylation | Uniprot | |
| S237 | Phosphorylation | Uniprot | |
| T239 | Phosphorylation | Uniprot | |
| K241 | Ubiquitination | Uniprot | |
| K247 | Ubiquitination | Uniprot | |
| K250 | Acetylation | Uniprot | |
| K250 | Ubiquitination | Uniprot | |
| S274 | Phosphorylation | Uniprot | |
| K304 | Acetylation | Uniprot | |
| K313 | Ubiquitination | Uniprot | |
| Y314 | Phosphorylation | Uniprot | |
| S333 | Phosphorylation | Uniprot | |
| K353 | Methylation | Uniprot | |
| K353 | Ubiquitination | Uniprot | |
| K359 | Ubiquitination | Uniprot | |
| C397 | S-Nitrosylation | Uniprot | |
| K399 | Sumoylation | Uniprot | |
| K399 | Ubiquitination | Uniprot | |
| T403 | Phosphorylation | Uniprot | |
| Y411 | Phosphorylation | Uniprot | |
| K426 | Ubiquitination | Uniprot | |
| Y432 | Phosphorylation | Uniprot | |
| T447 | Phosphorylation | Uniprot | |
| Y458 | Phosphorylation | Uniprot | |
| K464 | Ubiquitination | Uniprot | |
| K471 | Acetylation | Uniprot | |
| K471 | Ubiquitination | Uniprot | |
| K479 | Ubiquitination | Uniprot | |
| T484 | Phosphorylation | Uniprot |
研究背景
Actin-binding protein that contains 2 major actin binding sites. Organizes filamentous actin into parallel bundles. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration. Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF.
Phosphorylation at Ser-39 inhibits actin-binding. Phosphorylation is required for the reorganization of the actin cytoskeleton in response to NGF.
Cytoplasm>Cytosol. Cytoplasm>Cell cortex. Cytoplasm>Cytoskeleton. Cytoplasm>Cytoskeleton>Stress fiber. Cell projection>Filopodium. Cell projection>Invadopodium. Cell projection>Microvillus. Cell junction.
Note: Colocalized with RUFY3 and F-actin at filipodia of the axonal growth cone. Colocalized with DBN1 and F-actin at the transitional domain of the axonal growth cone (By similarity).
Ubiquitous.
Interacts with RUFY3 (via N-terminus); the interaction induces neuron axon development (By similarity). Interacts with NGFR (By similarity). Associates with CTNNB1 (By similarity). Interacts with PLXNB3.
Composed of four fascin beta-trefoil domains.
Belongs to the fascin family.
研究领域
· Human Diseases > Cancers: Overview > MicroRNAs in cancer.
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