产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF7993, RRID:AB_2841377.
展开/折叠
CD50; CDW 50; CDw50; ICAM 3; ICAM-3; ICAM-R; ICAM3; ICAM3_HUMAN; ICAMR; Intercellular adhesion molecule 3;
抗原和靶标
- P32942 ICAM3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MATMVPSVLWPRACWTLLVCCLLTPGVQGQEFLLRVEPQNPVLSAGGSLFVNCSTDCPSSEKIALETSLSKELVASGMGWAAFNLSNVTGNSRILCSVYCNGSQITGSSNITVYRLPERVELAPLPPWQPVGQNFTLRCQVEDGSPRTSLTVVLLRWEEELSRQPAVEEPAEVTATVLASRDDHGAPFSCRTELDMQPQGLGLFVNTSAPRQLRTFVLPVTPPRLVAPRFLEVETSWPVDCTLDGLFPASEAQVYLALGDQMLNATVMNHGDTLTATATATARADQEGAREIVCNVTLGGERREARENLTVFSFLGPIVNLSEPTAHEGSTVTVSCMAGARVQVTLDGVPAAAPGQPAQLQLNATESDDGRSFFCSATLEVDGEFLHRNSSVQLRVLYGPKIDRATCPQHLKWKDKTRHVLQCQARGNPYPELRCLKEGSSREVPVGIPFFVNVTHNGTYQCQASSSRGKYTLVVVMDIEAGSSHFVPVFVAVLLTLGVVTIVLALMYVFREHQRSGSYHVREESTYLPLTSMQPTEAMGEEPSRAE
翻译修饰 - P32942 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| N52 | N-Glycosylation | Uniprot | |
| N84 | N-Glycosylation | Uniprot | |
| N87 | N-Glycosylation | Uniprot | |
| N110 | N-Glycosylation | Uniprot | |
| N134 | N-Glycosylation | Uniprot | |
| T151 | Phosphorylation | Uniprot | |
| N206 | N-Glycosylation | Uniprot | |
| N295 | N-Glycosylation | Uniprot | |
| N363 | N-Glycosylation | Uniprot | |
| K401 | Ubiquitination | Uniprot | |
| K412 | Ubiquitination | Uniprot | |
| S516 | Phosphorylation | Uniprot | |
| S518 | Phosphorylation | Q04759 (PRKCQ) | Uniprot |
| Y519 | Phosphorylation | Uniprot | |
| S525 | Phosphorylation | Uniprot | |
| T526 | Phosphorylation | Uniprot | |
| Y527 | Phosphorylation | Uniprot | |
| T531 | Phosphorylation | Uniprot | |
| S532 | Phosphorylation | Uniprot | |
| T536 | Phosphorylation | Uniprot |
研究背景
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha-L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages.
Upon stimulation by a physiologic stimuli becomes rapidly and transiently phosphorylated on serine residues.
N-glycosylated; glycans consist of a mixture of tri- and tetra-antennary complex-type chains and high-mannose chains.
Membrane>Single-pass type I membrane protein.
Leukocytes.
Interacts with moesin/MSN.
Belongs to the immunoglobulin superfamily. ICAM family.
研究领域
· Environmental Information Processing > Signaling molecules and interaction > Cell adhesion molecules (CAMs). (View pathway)
限制条款
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