产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF8057, RRID:AB_2841413.
展开/折叠
DGU; DKFZp781L1143; HIGM 4; HIGM4; OTTHUMP00000240527; OTTHUMP00000240528; OTTHUMP00000240529; UDG; UNG 1; UNG 15; ung; UNG_HUMAN; UNG1; UNG15; UNG2; Uracil DNA glycosylase 1; Uracil DNA glycosylase 2; Uracil DNA glycosylase; Uracil-DNA glycosylase;
抗原和靶标
Isoform 1 is widely expressed with the highest expression in skeletal muscle, heart and testicles. Isoform 2 has the highest expression levels in tissues containing proliferating cells.
- P13051 UNG_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MIGQKTLYSFFSPSPARKRHAPSPEPAVQGTGVAGVPEESGDAAAIPAKKAPAGQEEPGTPPSSPLSAEQLDRIQRNKAAALLRLAARNVPVGFGESWKKHLSGEFGKPYFIKLMGFVAEERKHYTVYPPPHQVFTWTQMCDIKDVKVVILGQDPYHGPNQAHGLCFSVQRPVPPPPSLENIYKELSTDIEDFVHPGHGDLSGWAKQGVLLLNAVLTVRAHQANSHKERGWEQFTDAVVSWLNQNSNGLVFLLWGSYAQKKGSAIDRKRHHVLQTAHPSPLSVYRGFFGCRHFSKTNELLQKSGKKPIDWKEL
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P13051 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K5 | Acetylation | Uniprot | |
| K5 | Ubiquitination | Uniprot | |
| T6 | Phosphorylation | Uniprot | |
| Y8 | Phosphorylation | Uniprot | |
| S9 | Phosphorylation | Uniprot | |
| S12 | Phosphorylation | P24941 (CDK2) | Uniprot |
| S14 | Phosphorylation | Uniprot | |
| S23 | Phosphorylation | Uniprot | |
| T31 | Phosphorylation | Uniprot | |
| K49 | Ubiquitination | Uniprot | |
| K50 | Ubiquitination | Uniprot | |
| T60 | Phosphorylation | Uniprot | |
| S63 | Phosphorylation | Uniprot | |
| S64 | Phosphorylation | P06493 (CDK1) | Uniprot |
| S67 | Phosphorylation | Uniprot | |
| K78 | Ubiquitination | Uniprot | |
| K100 | Ubiquitination | Uniprot | |
| K108 | Ubiquitination | Uniprot | |
| Y125 | Phosphorylation | Uniprot | |
| T126 | Phosphorylation | Uniprot | |
| Y128 | Phosphorylation | Uniprot | |
| T188 | Phosphorylation | Uniprot | |
| K261 | Ubiquitination | Uniprot | |
| Y284 | Phosphorylation | Uniprot | |
| K295 | Acetylation | Uniprot | |
| K295 | Ubiquitination | Uniprot | |
| K302 | Ubiquitination | Uniprot |
研究背景
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
Isoform 1 is processed by cleavage of a transit peptide.
Mitochondrion.
Nucleus.
Isoform 1 is widely expressed with the highest expression in skeletal muscle, heart and testicles. Isoform 2 has the highest expression levels in tissues containing proliferating cells.
Monomer. Interacts with FAM72A.
(Microbial infection) Interacts with HIV-1 Vpr.
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
研究领域
· Genetic Information Processing > Replication and repair > Base excision repair.
· Human Diseases > Immune diseases > Primary immunodeficiency.
限制条款
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