| 产品: | Thymidylate Synthase 抗体 |
| 货号: | DF8096 |
| 描述: | Rabbit polyclonal antibody to Thymidylate Synthase |
| 应用: | WB |
| 反应: | Human, Monkey |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Chicken, Xenopus |
| 分子量: | 36 kDa; 36kD(Calculated). |
| 蛋白号: | P04818 |
| RRID: | AB_2841443 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF8096, RRID:AB_2841443.
展开/折叠
d TMP synthase; EC 2.1.1.45; HsT422; MGC88736; OTTHUMP00000162195; Thymidylate synthase; Thymidylate synthetase; TMS; TS; TSase; Tyms; TYMS protein; Tyms thymidylate synthetase; TYSY_HUMAN;
抗原和靶标
- P04818 TYSY_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPVAGSELPRRPLPPAAQERDAEPRPPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPHPTIKMEMAV
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P04818 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S6 | Phosphorylation | Uniprot | |
| T53 | Phosphorylation | Uniprot | |
| K77 | Ubiquitination | Uniprot | |
| K93 | Ubiquitination | Uniprot | |
| K99 | Ubiquitination | Uniprot | |
| K104 | Ubiquitination | Uniprot | |
| K107 | Ubiquitination | Uniprot | |
| S114 | Phosphorylation | Uniprot | |
| S120 | Phosphorylation | Uniprot | |
| S124 | Phosphorylation | P68400 (CSNK2A1) , P19784 (CSNK2A2) | Uniprot |
| Y135 | Phosphorylation | Uniprot | |
| Y146 | Phosphorylation | Uniprot | |
| S151 | Phosphorylation | Uniprot | |
| Y153 | Phosphorylation | Uniprot | |
| S154 | Phosphorylation | Uniprot | |
| T167 | Phosphorylation | Uniprot | |
| K169 | Ubiquitination | Uniprot | |
| K278 | Ubiquitination | Uniprot | |
| K284 | Ubiquitination | Uniprot | |
| K287 | Sumoylation | Uniprot | |
| K287 | Ubiquitination | Uniprot | |
| K292 | Sumoylation | Uniprot | |
| K292 | Ubiquitination | Uniprot | |
| K308 | Sumoylation | Uniprot | |
| K308 | Ubiquitination | Uniprot |
研究背景
Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.
Nucleus. Cytoplasm. Mitochondrion. Mitochondrion matrix. Mitochondrion inner membrane.
Homodimer.
Belongs to the thymidylate synthase family.
研究领域
· Human Diseases > Drug resistance: Antineoplastic > Antifolate resistance.
· Metabolism > Nucleotide metabolism > Pyrimidine metabolism.
· Metabolism > Metabolism of cofactors and vitamins > One carbon pool by folate.
· Metabolism > Global and overview maps > Metabolic pathways.
限制条款
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