产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF8117, RRID:AB_2841458.
展开/折叠
Cardiac inward rectifier potassium channel; HHBIRK 1; HHBIRK1; HHIRK 1; HHIRK1; HIRK 1; hIRK1; Inward rectifier K; Inward rectifier K(+) channel Kir2.1; Inward rectifier potassium channel 2; inwardly rectifying subfamily J member 2; IRK 1; IRK-1; IRK1; IRK2_HUMAN; KCNJ2; KIR2.1; LQT 7; LQT7; Potassium channel; Potassium channel inwardly rectifying subfamily J member 2; Potassium inwardly rectifying channel J2; Potassium inwardly rectifying channel subfamily J member 2; SQT 3; SQT3;
抗原和靶标
Heart, brain, placenta, lung, skeletal muscle, and kidney. Diffusely distributed throughout the brain.
- P63252 KCNJ2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFINVGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDASKEGKACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQDIDNADFEIVVILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHYYKVDYSRFHKTYEVPNTPLCSARDLAEKKYILSNANSFCYENEVALTSKEEDDSENGVPESTSTDTPPDIDLHNQASVPLEPRPLRRESEI
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P63252 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| G2 | Myristoylation | Uniprot | |
| Y9 | Phosphorylation | Uniprot | |
| S10 | Phosphorylation | Uniprot | |
| Y242 | Phosphorylation | Uniprot | |
| Y336 | Phosphorylation | Uniprot | |
| Y337 | Phosphorylation | Uniprot | |
| K338 | Ubiquitination | Uniprot | |
| Y341 | Phosphorylation | Uniprot | |
| S342 | Phosphorylation | Uniprot | |
| K346 | Ubiquitination | Uniprot | |
| Y366 | Phosphorylation | Uniprot | |
| S425 | Phosphorylation | P17612 (PRKACA) | Uniprot |
研究背景
Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium or cesium.
S-nitrosylation increases the open probability and inward rectifying currents.
Membrane>Multi-pass membrane protein. Membrane>Lipid-anchor.
Heart, brain, placenta, lung, skeletal muscle, and kidney. Diffusely distributed throughout the brain.
Homomultimeric and heteromultimeric association with KCNJ4/Kir2.3. Association, via its PDZ-recognition domain, with LIN7A, LIN7B, LIN7C, DLG1, CASK and APBA1 plays a key role in its localization and trafficking (By similarity).
Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily.
研究领域
· Organismal Systems > Nervous system > Cholinergic synapse.
· Organismal Systems > Endocrine system > Oxytocin signaling pathway.
· Organismal Systems > Endocrine system > Renin secretion.
· Organismal Systems > Digestive system > Gastric acid secretion.
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