| 产品: | FDPS 抗体 |
| 货号: | DF8118 |
| 描述: | Rabbit polyclonal antibody to FDPS |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Zebrafish, Bovine, Dog, Chicken, Xenopus |
| 分子量: | 48 kDa; 48kD(Calculated). |
| 蛋白号: | P14324 |
| RRID: | AB_2841459 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF8118, RRID:AB_2841459.
展开/折叠
(2E; (2E,6E) farnesyl diphosphate synthase; 6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; Farnesyl diphosphate synthetase; Farnesyl pyrophosphate synthase; Farnesyl pyrophosphate synthetase; Fdps; FPP synthase; FPP synthetase; FPPS; FPPS_HUMAN; FPS; Geranyltranstransferase;
抗原和靶标
- P14324 FPPS_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRALCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P14324 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K80 | Acetylation | Uniprot | |
| K80 | Ubiquitination | Uniprot | |
| S88 | Phosphorylation | Uniprot | |
| T95 | Phosphorylation | Uniprot | |
| K112 | Ubiquitination | Uniprot | |
| Y117 | Phosphorylation | Uniprot | |
| K123 | Acetylation | Uniprot | |
| K123 | Ubiquitination | Uniprot | |
| Y124 | Phosphorylation | Uniprot | |
| K142 | Ubiquitination | Uniprot | |
| K187 | Ubiquitination | Uniprot | |
| K210 | Ubiquitination | Uniprot | |
| K260 | Ubiquitination | Uniprot | |
| Y265 | Phosphorylation | Uniprot | |
| Y273 | Phosphorylation | Uniprot | |
| K332 | Ubiquitination | Uniprot | |
| S334 | Phosphorylation | Uniprot | |
| T345 | Phosphorylation | Uniprot | |
| Y349 | Phosphorylation | Uniprot | |
| K353 | Acetylation | Uniprot | |
| K353 | Ubiquitination | Uniprot | |
| K359 | Ubiquitination | Uniprot | |
| K363 | Ubiquitination | Uniprot |
研究背景
Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
Cytoplasm.
Homodimer. Interacts with RSAD2.
(Microbial infection) Interacts with HTLV-1 protein p13(II).
Belongs to the FPP/GGPP synthase family.
研究领域
· Human Diseases > Infectious diseases: Viral > Influenza A.
· Human Diseases > Infectious diseases: Viral > HTLV-I infection.
· Metabolism > Metabolism of terpenoids and polyketides > Terpenoid backbone biosynthesis.
· Metabolism > Global and overview maps > Metabolic pathways.
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