| 产品: | FNTA 抗体 |
| 货号: | DF8125 |
| 描述: | Rabbit polyclonal antibody to FNTA |
| 应用: | WB |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Horse, Sheep, Dog, Chicken |
| 分子量: | 44 kDa; 44kD(Calculated). |
| 蛋白号: | P49354 |
| RRID: | AB_2841463 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF8125, RRID:AB_2841463.
展开/折叠
CAAX farnesyltransferase alpha subunit; CAAX farnesyltransferase subunit alpha; EC 2.5.1.58; EC 2.5.1.59; Farnesyl protein transferase alpha subunit; Farnesyltransferase CAAX box alpha; Farnesyltransferase, CAAX box, alpha; Fnta; FNTA_HUMAN; FPTA; FTase alpha; FTase-alpha; GGTase I alpha; GGTase-I-alpha; MGC99680; OTTHUMP00000229206; OTTHUMP00000229262; PGGT1A; Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit; Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha; Protein prenyltransferase alpha subunit repeat containing 2; PTAR2; Ras proteins prenyltransferase alpha; Ras proteins prenyltransferase subunit alpha; Type I protein geranyl geranyltransferase alpha subunit; Type I protein geranyl-geranyltransferase subunit alpha;
抗原和靶标
- P49354 FNTA_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAATEGVGEAAQGGEPGQPAQPPPQPHPPPPQQQHKEEMAAEAGEAVASPMDDGFVSLDSPSYVLYRDRAEWADIDPVPQNDGPNPVVQIIYSDKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLKSLQKDLHEEMNYITAIIEEQPKNYQVWHHRRVLVEWLRDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFKLWDNELQYVDQLLKEDVRNNSVWNQRYFVISNTTGYNDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSKYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSTENDSPTNVQQ
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P49354 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| S49 | Phosphorylation | Uniprot | |
| S60 | Phosphorylation | Uniprot | |
| Y92 | Phosphorylation | Uniprot | |
| S93 | Phosphorylation | Uniprot | |
| K142 | Ubiquitination | Uniprot | |
| K198 | Ubiquitination | Uniprot | |
| K228 | Ubiquitination | Uniprot | |
| T247 | Phosphorylation | Uniprot | |
| T248 | Phosphorylation | Uniprot | |
| Y250 | Phosphorylation | Uniprot | |
| R253 | Methylation | Uniprot | |
| R287 | Methylation | Uniprot | |
| K336 | Ubiquitination | Uniprot | |
| K346 | Ubiquitination | Uniprot | |
| T350 | Phosphorylation | Uniprot | |
| Y358 | Phosphorylation | Uniprot | |
| K366 | Ubiquitination | Uniprot | |
| T369 | Phosphorylation | Uniprot | |
| S373 | Phosphorylation | Uniprot | |
| T375 | Phosphorylation | Uniprot |
研究背景
Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation.
Phosphorylated. Phosphorylation is mediated by MUSK upon AGRIN stimulation and results in the activation of FNTA (By similarity).
Interacts with MUSK; the interaction is direct and mediates AGRIN-induced phosphorylation of FNTA (By similarity). Heterodimer of FNTA and FNTB (farnesyltransferase). Heterodimer of FNTA and PGGT1B (geranylgeranyltransferase).
Belongs to the protein prenyltransferase subunit alpha family.
研究领域
· Metabolism > Metabolism of terpenoids and polyketides > Terpenoid backbone biosynthesis.
限制条款
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