PTS Antibody - #DF8130

(2)  
产品: PTS 抗体
货号: DF8130
描述: Rabbit polyclonal antibody to PTS
应用: WB IF/ICC
反应: Human
预测: Pig, Zebrafish, Bovine, Horse, Sheep, Dog, Chicken
分子量: 16 kDa; 16kD(Calculated).
蛋白号: Q03393
RRID: AB_2841466

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MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:1000-3000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human
预测:
Pig(100%), Zebrafish(100%), Bovine(100%), Horse(100%), Sheep(100%), Dog(100%), Chicken(88%)
克隆:
Polyclonal
特异性:
PTS Antibody detects endogenous levels of total PTS.
RRID:
AB_2841466
引用格式: Affinity Biosciences Cat# DF8130, RRID:AB_2841466.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

6 pyruvoyl tetrahydrobiopterin synthase; 6 pyruvoyl tetrahydropterin synthase; 6 pyruvoyltetrahydropterin synthase; 6-pyruvoyl tetrahydrobiopterin synthase; EC 4.2.3.12; FLJ97081; OTTHUMP00000235385; PTP synthase; PTPS; PTPS_HUMAN; PTS;

抗原和靶标

免疫原:
Uniprot:

Q03393(PTPS_HUMAN) >>Visit HPA database.

基因/基因ID:
PTS(5805)
序列:
MSTEGGGRRCQAQVSRRISFSASHRLYSKFLSDEENLKLFGKCNNPNGHGHNYKVVVTVHGEIDPATGMVMNLADLKKYMEEAIMQPLDHKNLDMDVPYFADVVSTTENVAVYIWDNLQKVLPVGVLYKVKVYETDNNIVVYKGE

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Zebrafish
100
Chicken
88
Xenopus
75
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q03393 作为底物

Site PTM Type Enzyme
S19 Phosphorylation Q13976 (PRKG1) , Q13237 (PRKG2)
S21 Phosphorylation
S23 Phosphorylation
K29 Ubiquitination
S32 Phosphorylation
K38 Ubiquitination
K42 Ubiquitination
K77 Ubiquitination
Y128 Phosphorylation
K129 Ubiquitination
K131 Ubiquitination
K143 Ubiquitination

研究背景

功能:

Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.

翻译修饰:

Phosphorylation of Ser-19 is required for maximal enzyme activity.

亚基结构:

Homohexamer formed of two homotrimers in a head to head fashion.

蛋白家族:

Belongs to the PTPS family.

研究领域

· Metabolism > Metabolism of cofactors and vitamins > Folate biosynthesis.

· Metabolism > Global and overview maps > Metabolic pathways.

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