| 产品: | GPR40 抗体 |
| 货号: | DF8146 |
| 描述: | Rabbit polyclonal antibody to GPR40 |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Sheep, Rabbit, Dog |
| 分子量: | 31 kDa; 31kD(Calculated). |
| 蛋白号: | O14842 |
| RRID: | AB_2841477 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF8146, RRID:AB_2841477.
展开/折叠
FFA1R; FFAR 1; Ffar1; FFAR1_HUMAN; Free fatty acid receptor 1; G protein coupled receptor 40; G-protein coupled receptor 40; GPCR40; GPR 40; GPR40;
抗原和靶标
- O14842 FFAR1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - O14842 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T31 | Phosphorylation | Uniprot | |
| S298 | Phosphorylation | Uniprot |
研究背景
G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation (By similarity). Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway.
Cell membrane>Multi-pass membrane protein.
Detected in brain and pancreas. Detected in pancreatic beta cells.
Belongs to the G-protein coupled receptor 1 family.
研究领域
· Organismal Systems > Endocrine system > Insulin secretion. (View pathway)
限制条款
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