alpha 2 Macroglobulin/A2M Antibody - #DF8174
| 产品: | alpha 2 Macroglobulin/A2M 抗体 |
| 货号: | DF8174 |
| 描述: | Rabbit polyclonal antibody to alpha 2 Macroglobulin/A2M |
| 应用: | WB |
| 反应: | Human, Mouse, Rat |
| 分子量: | 180 kDa; 163kD(Calculated). |
| 蛋白号: | P01023 |
| RRID: | AB_2841493 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF8174, RRID:AB_2841493.
展开/折叠
A2m; A2MG_HUMAN; Alpha 2 M; Alpha 2M; Alpha-2-M; Alpha-2-macroglobulin; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5; CPAMD5; DKFZp779B086; FWP007; S863 7;
抗原和靶标
- P01023 A2MG_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGKNKLLHPSLVLLLLVLLPTDASVSGKPQYMVLVPSLLHTETTEKGCVLLSYLNETVTVSASLESVRGNRSLFTDLEAENDVLHCVAFAVPKSSSNEEVMFLTVQVKGPTQEFKKRTTVMVKNEDSLVFVQTDKSIYKPGQTVKFRVVSMDENFHPLNELIPLVYIQDPKGNRIAQWQSFQLEGGLKQFSFPLSSEPFQGSYKVVVQKKSGGRTEHPFTVEEFVLPKFEVQVTVPKIITILEEEMNVSVCGLYTYGKPVPGHVTVSICRKYSDASDCHGEDSQAFCEKFSGQLNSHGCFYQQVKTKVFQLKRKEYEMKLHTEAQIQEEGTVVELTGRQSSEITRTITKLSFVKVDSHFRQGIPFFGQVRLVDGKGVPIPNKVIFIRGNEANYYSNATTDEHGLVQFSINTTNVMGTSLTVRVNYKDRSPCYGYQWVSEEHEEAHHTAYLVFSPSKSFVHLEPMSHELPCGHTQTVQAHYILNGGTLLGLKKLSFYYLIMAKGGIVRTGTHGLLVKQEDMKGHFSISIPVKSDIAPVARLLIYAVLPTGDVIGDSAKYDVENCLANKVDLSFSPSQSLPASHAHLRVTAAPQSVCALRAVDQSVLLMKPDAELSASSVYNLLPEKDLTGFPGPLNDQDNEDCINRHNVYINGITYTPVSSTNEKDMYSFLEDMGLKAFTNSKIRKPKMCPQLQQYEMHGPEGLRVGFYESDVMGRGHARLVHVEEPHTETVRKYFPETWIWDLVVVNSAGVAEVGVTVPDTITEWKAGAFCLSEDAGLGISSTASLRAFQPFFVELTMPYSVIRGEAFTLKATVLNYLPKCIRVSVQLEASPAFLAVPVEKEQAPHCICANGRQTVSWAVTPKSLGNVNFTVSAEALESQELCGTEVPSVPEHGRKDTVIKPLLVEPEGLEKETTFNSLLCPSGGEVSEELSLKLPPNVVEESARASVSVLGDILGSAMQNTQNLLQMPYGCGEQNMVLFAPNIYVLDYLNETQQLTPEIKSKAIGYLNTGYQRQLNYKHYDGSYSTFGERYGRNQGNTWLTAFVLKTFAQARAYIFIDEAHITQALIWLSQRQKDNGCFRSSGSLLNNAIKGGVEDEVTLSAYITIALLEIPLTVTHPVVRNALFCLESAWKTAQEGDHGSHVYTKALLAYAFALAGNQDKRKEVLKSLNEEAVKKDNSVHWERPQKPKAPVGHFYEPQAPSAEVEMTSYVLLAYLTAQPAPTSEDLTSATNIVKWITKQQNAQGGFSSTQDTVVALHALSKYGAATFTRTGKAAQVTIQSSGTFSSKFQVDNNNRLLLQQVSLPELPGEYSMKVTGEGCVYLQTSLKYNILPEKEEFPFALGVQTLPQTCDEPKAHTSFQISLSVSYTGSRSASNMAIVDVKMVSGFIPLKPTVKMLERSNHVSRTEVSSNHVLIYLDKVSNQTLSLFFTVLQDVPVRDLKPAIVKVYDYYETDEFAIAEYNAPCSKDLGNA
翻译修饰 - P01023 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| N55 | N-Glycosylation | Uniprot | |
| N70 | N-Glycosylation | Uniprot | |
| N247 | N-Glycosylation | Uniprot | |
| T346 | Phosphorylation | Uniprot | |
| N396 | N-Glycosylation | Uniprot | |
| N410 | N-Glycosylation | Uniprot | |
| Y497 | Phosphorylation | Uniprot | |
| T679 | Phosphorylation | Uniprot | |
| Y695 | Phosphorylation | Uniprot | |
| Y708 | Phosphorylation | Uniprot | |
| S710 | Phosphorylation | Uniprot | |
| Y817 | Phosphorylation | Uniprot | |
| K820 | Acetylation | Uniprot | |
| T861 | Phosphorylation | Uniprot | |
| N869 | N-Glycosylation | Uniprot | |
| T898 | Phosphorylation | Uniprot | |
| N991 | N-Glycosylation | Uniprot | |
| Y1007 | Phosphorylation | Uniprot | |
| Y1012 | Phosphorylation | Uniprot | |
| Y1021 | Phosphorylation | Uniprot | |
| Y1025 | Phosphorylation | Uniprot | |
| K1147 | Acetylation | Uniprot | |
| K1162 | Acetylation | Uniprot | |
| K1164 | Acetylation | Uniprot | |
| K1168 | Acetylation | Uniprot | |
| S1387 | Phosphorylation | Uniprot | |
| T1395 | Phosphorylation | Uniprot | |
| N1424 | N-Glycosylation | Uniprot |
研究背景
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
Secreted.
Secreted in plasma.
Homotetramer; disulfide-linked.
Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
研究领域
· Organismal Systems > Immune system > Complement and coagulation cascades. (View pathway)
限制条款
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