| 产品: | NudC 抗体 |
| 货号: | DF8191 |
| 描述: | Rabbit polyclonal antibody to NudC |
| 应用: | WB IF/ICC |
| 反应: | Human |
| 预测: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 42 kDa; 38kD(Calculated). |
| 蛋白号: | Q9Y266 |
| RRID: | AB_2841501 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF8191, RRID:AB_2841501.
展开/折叠
HNUDC; MNUDC; MNUDC protein; NPD011; Nuclear distribution C homolog; Nuclear distribution gene C (A.nidulans) homolog; Nuclear distribution gene C homolog; Nuclear distribution gene C homolog (A. nidulans); Nuclear distribution protein C homolog; Nuclear migration protein nudC; nudC; NudC nuclear distribution protein; NUDC_HUMAN; OTTHUMP00000004405; SIG 92; SIG92;
抗原和靶标
Ubiquitous. Highly expressed in fetal liver, kidney, lung and brain. Highly expressed in adult pancreas, kidney, skeletal muscle, liver, lung, placenta, prostate, brain and heart.
- Q9Y266 NUDC_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGGEQEEERFDGMLLAMAQQHEGGVQELVNTFFSFLRRKTDFFIGGEEGMAEKLITQTFSHHNQLAQKTRREKRARQEAERREKAERAARLAKEAKSETSGPQIKELTDEEAERLQLEIDQKKDAENHEAQLKNGSLDSPGKQDTEEDEEEDEKDKGKLKPNLGNGADLPNYRWTQTLSELDLAVPFCVNFRLKGKDMVVDIQRRHLRVGLKGQPAIIDGELYNEVKVEESSWLIEDGKVVTVHLEKINKMEWWSRLVSSDPEINTKKINPENSKLSDLDSETRSMVEKMMYDQRQKSMGLPTSDEQKKQEILKKFMDQHPEMDFSKAKFN
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9Y266 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K39 | Acetylation | Uniprot | |
| K39 | Ubiquitination | Uniprot | |
| T40 | Phosphorylation | Uniprot | |
| K53 | Ubiquitination | Uniprot | |
| T58 | Phosphorylation | Uniprot | |
| S60 | Phosphorylation | Uniprot | |
| K68 | Acetylation | Uniprot | |
| K68 | Ubiquitination | Uniprot | |
| K93 | Acetylation | Uniprot | |
| K96 | Sumoylation | Uniprot | |
| K96 | Ubiquitination | Uniprot | |
| T99 | Phosphorylation | Uniprot | |
| S100 | Phosphorylation | Uniprot | |
| K105 | Ubiquitination | Uniprot | |
| T108 | Phosphorylation | Uniprot | |
| K122 | Ubiquitination | Uniprot | |
| K133 | Ubiquitination | Uniprot | |
| S136 | Phosphorylation | P24941 (CDK2) | Uniprot |
| S139 | Phosphorylation | P24941 (CDK2) | Uniprot |
| T145 | Phosphorylation | Uniprot | |
| K196 | Acetylation | Uniprot | |
| K196 | Ubiquitination | Uniprot | |
| K212 | Ubiquitination | Uniprot | |
| Y223 | Phosphorylation | Uniprot | |
| K239 | Acetylation | Uniprot | |
| K250 | Ubiquitination | Uniprot | |
| S259 | Phosphorylation | Uniprot | |
| S260 | Phosphorylation | Uniprot | |
| T266 | Phosphorylation | Uniprot | |
| K267 | Acetylation | Uniprot | |
| K267 | Ubiquitination | Uniprot | |
| K268 | Ubiquitination | Uniprot | |
| S274 | Phosphorylation | P53350 (PLK1) | Uniprot |
| K275 | Ubiquitination | Uniprot | |
| S277 | Phosphorylation | Uniprot | |
| S281 | Phosphorylation | Uniprot | |
| S285 | Phosphorylation | Uniprot | |
| K289 | Ubiquitination | Uniprot | |
| Y292 | Phosphorylation | Uniprot | |
| K297 | Ubiquitination | Uniprot | |
| S298 | Phosphorylation | Uniprot | |
| S304 | Phosphorylation | Uniprot | |
| K308 | Ubiquitination | Uniprot | |
| K315 | Ubiquitination | Uniprot | |
| S326 | Phosphorylation | P53350 (PLK1) | Uniprot |
| K327 | Methylation | Uniprot | |
| K327 | Ubiquitination | Uniprot | |
| K329 | Methylation | Uniprot |
研究背景
Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation.
Reversibly phosphorylated on serine residues during the M phase of the cell cycle. Phosphorylation on Ser-274 and Ser-326 is necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Phosphorylated by PLK and other kinases.
Cytoplasm>Cytoskeleton. Nucleus.
Note: In a filamentous pattern adjacent to the nucleus of migrating cerebellar granule cells. Colocalizes with tubulin and dynein and with the microtubule organizing center. Distributed throughout the cytoplasm of non-migrating cells. A small proportion is nuclear, in a punctate pattern.
Ubiquitous. Highly expressed in fetal liver, kidney, lung and brain. Highly expressed in adult pancreas, kidney, skeletal muscle, liver, lung, placenta, prostate, brain and heart.
Interacts with PAFAH1B1 (By similarity). Interacts with PLK1. Part of a complex containing PLK1, NUDC, dynein and dynactin. Interacts with DCDC1.
Belongs to the nudC family.
限制条款
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