TRPM7 Antibody - #DF8300

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产品: TRPM7 抗体
货号: DF8300
描述: Rabbit polyclonal antibody to TRPM7
应用: WB
反应: Human
预测: Pig, Bovine, Horse, Sheep, Rabbit, Dog
分子量: 213 kDa; 213kD(Calculated).
蛋白号: Q96QT4
RRID: AB_2841583

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   规格 价格 库存
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MS Report
HPLC Report
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:1000-3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human
预测:
Pig(100%), Bovine(91%), Horse(82%), Sheep(91%), Rabbit(100%), Dog(91%)
克隆:
Polyclonal
特异性:
TRPM7 Antibody detects endogenous levels of total TRPM7.
RRID:
AB_2841583
引用格式: Affinity Biosciences Cat# DF8300, RRID:AB_2841583.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

ALSPDC; CHAK; CHAK1; Channel kinase 1; Channel-kinase 1; Long transient receptor potential channel 7; LTrpC-7; LTrpC7; Transient receptor potential cation channel subfamily M member 7; TRP PLIK; TRPM7; TRPM7_HUMAN;

抗原和靶标

免疫原:
Uniprot:

Q96QT4(TRPM7_HUMAN) >>Visit HPA database.

基因/基因ID:
TRPM7(54822)
序列:
MSQKSWIESTLTKRECVYIIPSSKDPHRCLPGCQICQQLVRCFCGRLVKQHACFTASLAMKYSDVKLGDHFNQAIEEWSVEKHTEQSPTDAYGVINFQGGSHSYRAKYVRLSYDTKPEVILQLLLKEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTTGAWILTGGVNTGVAKHVGDALKEHASRSSRKICTIGIAPWGVIENRNDLVGRDVVAPYQTLLNPLSKLNVLNNLHSHFILVDDGTVGKYGAEVRLRRELEKTINQQRIHARIGQGVPVVALIFEGGPNVILTVLEYLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPDAAEPDIISTIKKTFNFGQNEALHLFQTLMECMKRKELITVFHIGSDEHQDIDVAILTALLKGTNASAFDQLILTLAWDRVDIAKNHVFVYGQQWLVGSLEQAMLDALVMDRVAFVKLLIENGVSMHKFLTIPRLEELYNTKQGPTNPMLFHLVRDVKQGNLPPGYKITLIDIGLVIEYLMGGTYRCTYTRKRFRLIYNSLGGNNRRSGRNTSSSTPQLRKSHESFGNRADKKEKMRHNHFIKTAQPYRPKIDTVMEEGKKKRTKDEIVDIDDPETKRFPYPLNELLIWACLMKRQVMARFLWQHGEESMAKALVACKIYRSMAYEAKQSDLVDDTSEELKQYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNSTCLKLAVSSRLRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILLLEYKTKAEMSHIPQSQDAHQMTMDDSENNFQNITEEIPMEVFKEVRILDSNEGKNEMEIQMKSKKLPITRKFYAFYHAPIVKFWFNTLAYLGFLMLYTFVVLVQMEQLPSVQEWIVIAYIFTYAIEKVREIFMSEAGKVNQKIKVWFSDYFNISDTIAIISFFIGFGLRFGAKWNFANAYDNHVFVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKAILYPHEAPSWTLAKDIVFHPYWMIFGEVYAYEIDVCANDSVIPQICGPGTWLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEKPVLPPPLIILSHIVSLFCCICKRRKKDKTSDGPKLFLTEEDQKKLHDFEEQCVEMYFNEKDDKFHSGSEERIRVTFERVEQMCIQIKEVGDRVNYIKRSLQSLDSQIGHLQDLSALTVDTLKTLTAQKASEASKVHNEITRELSISKHLAQNLIDDGPVRPSVWKKHGVVNTLSSSLPQGDLESNNPFHCNILMKDDKDPQCNIFGQDLPAVPQRKEFNFPEAGSSSGALFPSAVSPPELRQRLHGVELLKIFNKNQKLGSSSTSIPHLSSPPTKFFVSTPSQPSCKSHLETGTKDQETVCSKATEGDNTEFGAFVGHRDSMDLQRFKETSNKIKILSNNNTSENTLKRVSSLAGFTDCHRTSIPVHSKQAEKISRRPSTEDTHEVDSKAALIPDWLQDRPSNREMPSEEGTLNGLTSPFKPAMDTNYYYSAVERNNLMRLSQSIPFTPVPPRGEPVTVYRLEESSPNILNNSMSSWSQLGLCAKIEFLSKEEMGGGLRRAVKVQCTWSEHDILKSGHLYIIKSFLPEVVNTWSSIYKEDTVLHLCLREIQQQRAAQKLTFAFNQMKPKSIPYSPRFLEVFLLYCHSAGQWFAVEECMTGEFRKYNNNNGDEIIPTNTLEEIMLAFSHWTYEYTRGELLVLDLQGVGENLTDPSVIKAEEKRSCDMVFGPANLGEDAIKNFRAKHHCNSCCRKLKLPDLKRNDYTPDKIIFPQDEPSDLNLQPGNSTKESESTNSVRLML

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Rabbit
100
Pig
100
Bovine
91
Sheep
91
Dog
91
Horse
82
Chicken
73
Xenopus
0
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q96QT4 作为底物

Site PTM Type Enzyme
M1 Acetylation
S5 Phosphorylation
T12 Phosphorylation
S57 Phosphorylation
K66 Ubiquitination
S101 Phosphorylation
K189 Ubiquitination
S233 Phosphorylation
K351 Ubiquitination
T523 Phosphorylation
S554 Phosphorylation
T555 Phosphorylation
K667 Ubiquitination
S764 Phosphorylation
Y776 Phosphorylation
T778 Phosphorylation
K827 Ubiquitination
S907 Phosphorylation
K1159 Ubiquitination
T1163 Phosphorylation Q96QT4 (TRPM7)
K1168 Acetylation
S1191 Phosphorylation Q96QT4 (TRPM7)
S1193 Phosphorylation Q96QT4 (TRPM7)
S1230 Phosphorylation
S1239 Phosphorylation
K1253 Ubiquitination
S1255 Phosphorylation Q96QT4 (TRPM7)
S1258 Phosphorylation Q96QT4 (TRPM7)
T1265 Phosphorylation Q96QT4 (TRPM7)
S1269 Phosphorylation
S1271 Phosphorylation Q96QT4 (TRPM7)
S1287 Phosphorylation Q96QT4 (TRPM7)
S1358 Phosphorylation Q96QT4 (TRPM7)
S1361 Phosphorylation
S1386 Phosphorylation
S1387 Phosphorylation Q96QT4 (TRPM7)
S1390 Phosphorylation Q96QT4 (TRPM7)
S1395 Phosphorylation
S1396 Phosphorylation
S1404 Phosphorylation Q96QT4 (TRPM7)
T1405 Phosphorylation Q96QT4 (TRPM7)
S1407 Phosphorylation Q96QT4 (TRPM7)
S1410 Phosphorylation
S1413 Phosphorylation
T1417 Phosphorylation
T1419 Phosphorylation
T1435 Phosphorylation Q96QT4 (TRPM7)
S1446 Phosphorylation Q96QT4 (TRPM7)
T1455 Phosphorylation Q96QT4 (TRPM7)
S1456 Phosphorylation Q96QT4 (TRPM7)
S1463 Phosphorylation Q96QT4 (TRPM7)
S1468 Phosphorylation Q96QT4 (TRPM7)
T1471 Phosphorylation Q96QT4 (TRPM7)
K1473 Methylation
K1473 Ubiquitination
S1476 Phosphorylation Q96QT4 (TRPM7)
S1477 Phosphorylation Q96QT4 (TRPM7)
T1482 Phosphorylation Q96QT4 (TRPM7)
S1488 Phosphorylation
S1493 Phosphorylation Q96QT4 (TRPM7)
S1500 Phosphorylation
S1504 Phosphorylation
T1505 Phosphorylation Q96QT4 (TRPM7)
T1508 Phosphorylation Q96QT4 (TRPM7)
S1513 Phosphorylation Q96QT4 (TRPM7)
S1527 Phosphorylation Q96QT4 (TRPM7)
S1533 Phosphorylation Q96QT4 (TRPM7)
T1537 Phosphorylation Q96QT4 (TRPM7)
T1542 Phosphorylation Q96QT4 (TRPM7)
S1543 Phosphorylation Q96QT4 (TRPM7)
T1551 Phosphorylation Q96QT4 (TRPM7)
S1567 Phosphorylation Q96QT4 (TRPM7)
S1569 Phosphorylation Q96QT4 (TRPM7)
T1583 Phosphorylation Q96QT4 (TRPM7)
S1598 Phosphorylation Q96QT4 (TRPM7)
S1615 Phosphorylation Q96QT4 (TRPM7)
S1660 Phosphorylation Q96QT4 (TRPM7)
T1685 Phosphorylation Q96QT4 (TRPM7)
S1695 Phosphorylation Q96QT4 (TRPM7)
S1779 Phosphorylation Q96QT4 (TRPM7)
T1830 Phosphorylation Q96QT4 (TRPM7)
K1833 Ubiquitination
S1851 Phosphorylation Q96QT4 (TRPM7)
S1860 Phosphorylation Q96QT4 (TRPM7)

翻译修饰 - Q96QT4 作为激酶

Substrate Site Source
O00418 (EEF2K) S78 Uniprot
P04083 (ANXA1) S5 Uniprot
P28289 (TMOD1) S2 Uniprot
P28289 (TMOD1) T54 Uniprot
P35579 (MYH9) T1800 Uniprot
P35579 (MYH9) S1803 Uniprot
P35579 (MYH9) S1808 Uniprot
Q96QT4 (TRPM7) T1163 Uniprot
Q96QT4 (TRPM7) S1191 Uniprot
Q96QT4 (TRPM7) S1193 Uniprot
Q96QT4 (TRPM7) S1255 Uniprot
Q96QT4 (TRPM7) S1258 Uniprot
Q96QT4 (TRPM7) T1265 Uniprot
Q96QT4 (TRPM7) S1271 Uniprot
Q96QT4 (TRPM7) S1287 Uniprot
Q96QT4 (TRPM7) S1358 Uniprot
Q96QT4 (TRPM7) S1387 Uniprot
Q96QT4 (TRPM7) S1390 Uniprot
Q96QT4 (TRPM7) S1404 Uniprot
Q96QT4 (TRPM7) T1405 Uniprot
Q96QT4 (TRPM7) S1407 Uniprot
Q96QT4 (TRPM7) T1435 Uniprot
Q96QT4 (TRPM7) S1446 Uniprot
Q96QT4 (TRPM7) T1455 Uniprot
Q96QT4 (TRPM7) S1456 Uniprot
Q96QT4 (TRPM7) S1463 Uniprot
Q96QT4 (TRPM7) S1468 Uniprot
Q96QT4 (TRPM7) T1471 Uniprot
Q96QT4 (TRPM7) S1476 Uniprot
Q96QT4 (TRPM7) S1477 Uniprot
Q96QT4 (TRPM7) T1482 Uniprot
Q96QT4 (TRPM7) S1493 Uniprot
Q96QT4 (TRPM7) T1505 Uniprot
Q96QT4 (TRPM7) T1508 Uniprot
Q96QT4 (TRPM7) S1513 Uniprot
Q96QT4 (TRPM7) S1527 Uniprot
Q96QT4 (TRPM7) S1533 Uniprot
Q96QT4 (TRPM7) T1537 Uniprot
Q96QT4 (TRPM7) T1542 Uniprot
Q96QT4 (TRPM7) S1543 Uniprot
Q96QT4 (TRPM7) T1551 Uniprot
Q96QT4 (TRPM7) S1567 Uniprot
Q96QT4 (TRPM7) S1569 Uniprot
Q96QT4 (TRPM7) T1583 Uniprot
Q96QT4 (TRPM7) S1598 Uniprot
Q96QT4 (TRPM7) S1615 Uniprot
Q96QT4 (TRPM7) S1660 Uniprot
Q96QT4 (TRPM7) T1685 Uniprot
Q96QT4 (TRPM7) S1695 Uniprot
Q96QT4 (TRPM7) S1779 Uniprot
Q96QT4 (TRPM7) T1830 Uniprot
Q96QT4 (TRPM7) S1851 Uniprot
Q96QT4 (TRPM7) S1860 Uniprot

研究背景

功能:

Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).

翻译修饰:

Autophosphorylated.

细胞定位:

Membrane>Multi-pass membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
亚基结构:

Homodimer. Interacts with PLCB1 (By similarity). Forms heterodimers with TRPM6.

蛋白家族:

In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.

In the N-terminal section; belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM7 sub-subfamily.

研究领域

· Cellular Processes > Cell growth and death > Necroptosis.   (View pathway)

· Cellular Processes > Cell growth and death > Cellular senescence.   (View pathway)

· Organismal Systems > Immune system > NOD-like receptor signaling pathway.   (View pathway)

· Organismal Systems > Digestive system > Mineral absorption.

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