产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF8315, RRID:AB_2841593.
展开/折叠
70 kDa peroxisomal membrane protein; ABC 43; ABC D3; ABC43; ABCD 3; Abcd3; ABCD3 protein; ABCD3_HUMAN; ATP binding cassette sub family D (ALD) member 3; ATP binding cassette sub family D member 3; ATP-binding cassette sub-family D member 3; CBAS5; dJ824O18.1 (ATP-binding cassette, sub family D (ALD), member 3 (PMP70, PXMP1)); Peroxisomal membrane protein 1 (70kD); Peroxisomal membrane protein 1 (70kD, Zellweger syndrome); Peroxisomal membrane protein 1; PMP 70; PMP70; PXMP 1; PXMP1; ZWS2;
抗原和靶标
- P28288 ABCD3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAAFSKYLTARNSSLAGAAFLLLCLLHKRRRALGLHGKKSGKPPLQNNEKEGKKERAVVDKVFFSRLIQILKIMVPRTFCKETGYLVLIAVMLVSRTYCDVWMIQNGTLIESGIIGRSRKDFKRYLLNFIAAMPLISLVNNFLKYGLNELKLCFRVRLTKYLYEEYLQAFTYYKMGNLDNRIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLDIVLYIFKLTSAIGAQGPASMMAYLVVSGLFLTRLRRPIGKMTITEQKYEGEYRYVNSRLITNSEEIAFYNGNKREKQTVHSVFRKLVEHLHNFILFRFSMGFIDSIIAKYLATVVGYLVVSRPFLDLSHPRHLKSTHSELLEDYYQSGRMLLRMSQALGRIVLAGREMTRLAGFTARITELMQVLKDLNHGKYERTMVSQQEKGIEGVQVIPLIPGAGEIIIADNIIKFDHVPLATPNGDVLIRDLNFEVRSGANVLICGPNGCGKSSLFRVLGELWPLFGGRLTKPERGKLFYVPQRPYMTLGTLRDQVIYPDGREDQKRKGISDLVLKEYLDNVQLGHILEREGGWDSVQDWMDVLSGGEKQRMAMARLFYHKPQFAILDECTSAVSVDVEGYIYSHCRKVGITLFTVSHRKSLWKHHEYYLHMDGRGNYEFKQITEDTVEFGS
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P28288 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K6 | Acetylation | Uniprot | |
| K6 | Ubiquitination | Uniprot | |
| C24 | S-Nitrosylation | Uniprot | |
| K38 | Ubiquitination | Uniprot | |
| K39 | Ubiquitination | Uniprot | |
| S40 | Phosphorylation | Uniprot | |
| K42 | Ubiquitination | Uniprot | |
| K50 | Ubiquitination | Uniprot | |
| K61 | Ubiquitination | Uniprot | |
| S65 | Phosphorylation | Uniprot | |
| S95 | Phosphorylation | Uniprot | |
| Y145 | Phosphorylation | Uniprot | |
| Y163 | Phosphorylation | Uniprot | |
| Y173 | Phosphorylation | Uniprot | |
| K253 | Ubiquitination | Uniprot | |
| K260 | Acetylation | Uniprot | |
| K260 | Ubiquitination | Uniprot | |
| K286 | Ubiquitination | Uniprot | |
| K347 | Ubiquitination | Uniprot | |
| Y357 | Phosphorylation | Uniprot | |
| Y358 | Phosphorylation | Uniprot | |
| S360 | Phosphorylation | Uniprot | |
| T388 | Phosphorylation | Uniprot | |
| K399 | Acetylation | Uniprot | |
| K399 | Ubiquitination | Uniprot | |
| K405 | Ubiquitination | Uniprot | |
| K416 | Ubiquitination | Uniprot | |
| T449 | Phosphorylation | Uniprot | |
| C472 | S-Nitrosylation | Uniprot | |
| K479 | Ubiquitination | Uniprot | |
| K504 | Ubiquitination | Uniprot | |
| Y525 | Phosphorylation | Uniprot | |
| K533 | Acetylation | Uniprot | |
| K533 | Ubiquitination | Uniprot | |
| K535 | Ubiquitination | Uniprot | |
| K543 | Ubiquitination | Uniprot | |
| Y545 | Phosphorylation | Uniprot | |
| S572 | Phosphorylation | Uniprot | |
| K576 | Ubiquitination | Uniprot | |
| K631 | Acetylation | Uniprot | |
| Y635 | Phosphorylation | Uniprot | |
| Y636 | Phosphorylation | Uniprot | |
| Y645 | Phosphorylation | Uniprot | |
| T654 | Phosphorylation | Uniprot | |
| S659 | Phosphorylation | Uniprot |
研究背景
Probable transporter involved in the transport of branched-chain fatty acids and C27 bile acids into the peroxisome; the latter function is a crucial step in bile acid biosynthesis. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity.
Peroxisome membrane>Multi-pass membrane protein.
Can form heterodimers with ABCD1/ALD and ABCD2/ALDR. Dimerization is necessary to form an active transporter. Interacts with PEX19.
Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
研究领域
· Cellular Processes > Transport and catabolism > Peroxisome. (View pathway)
· Environmental Information Processing > Membrane transport > ABC transporters.
限制条款
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