产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF8317, RRID:AB_2841595.
展开/折叠
BACH 1; BACH 1.3; Bach1; BACH1_HUMAN; Basic leucine zipper transcription factor 1; basic region leucine zipper transcriptional regulator BACH1; BTB and CNC homolog 1; BTB and CNC homology 1; BTB and CNC homology 1, basic leucine zipper transcription factor 1; HA2303; OTTHUMP00000096563; OTTHUMP00000096564; Transcription regulator protein BACH1;
抗原和靶标
- O14867 BACH1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSLSENSVFAYESSVHSTNVLLSLNDQRKKDVLCDVTIFVEGQRFRAHRSVLAACSSYFHSRIVGQADGELNITLPEEVTVKGFEPLIQFAYTAKLILSKENVDEVCKCVEFLSVHNIEESCFQFLKFKFLDSTADQQECPRKKCFSSHCQKTDLKLSLLDQRDLETDEVEEFLENKNVQTPQCKLRRYQGNAKASPPLQDSASQTYESMCLEKDAALALPSLCPKYRKFQKAFGTDRVRTGESSVKDIHASVQPNERSENECLGGVPECRDLQVMLKCDESKLAMEPEETKKDPASQCPTEKSEVTPFPHNSSIDPHGLYSLSLLHTYDQYGDLNFAGMQNTTVLTEKPLSGTDVQEKTFGESQDLPLKSDLGTREDSSVASSDRSSVEREVAEHLAKGFWSDICSTDTPCQMQLSPAVAKDGSEQISQKRSECPWLGIRISESPEPGQRTFTTLSSVNCPFISTLSTEGCSSNLEIGNDDYVSEPQQEPCPYACVISLGDDSETDTEGDSESCSAREQECEVKLPFNAQRIISLSRNDFQSLLKMHKLTPEQLDCIHDIRRRSKNRIAAQRCRKRKLDCIQNLESEIEKLQSEKESLLKERDHILSTLGETKQNLTGLCQKVCKEAALSQEQIQILAKYSAADCPLSFLISEKDKSTPDGELALPSIFSLSDRPPAVLPPCARGNSEPGYARGQESQQMSTATSEQAGPAEQCRQSGGISDFCQQMTDKCTTDE
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - O14867 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K100 | Ubiquitination | Uniprot | |
| K129 | Ubiquitination | Uniprot | |
| K156 | Ubiquitination | Uniprot | |
| S158 | Phosphorylation | Uniprot | |
| K177 | Ubiquitination | Uniprot | |
| T181 | Phosphorylation | Uniprot | |
| K185 | Ubiquitination | Uniprot | |
| S196 | Phosphorylation | Uniprot | |
| K232 | Ubiquitination | Uniprot | |
| T236 | Phosphorylation | Uniprot | |
| K247 | Ubiquitination | Uniprot | |
| K359 | Ubiquitination | Uniprot | |
| T360 | Phosphorylation | Uniprot | |
| S364 | Phosphorylation | Uniprot | |
| K370 | Ubiquitination | Uniprot | |
| S379 | Phosphorylation | Uniprot | |
| S388 | Phosphorylation | Uniprot | |
| S417 | Phosphorylation | Uniprot | |
| S445 | Phosphorylation | Uniprot | |
| S504 | Phosphorylation | Uniprot | |
| T506 | Phosphorylation | Uniprot | |
| S543 | Phosphorylation | Uniprot | |
| K549 | Ubiquitination | Uniprot | |
| T551 | Phosphorylation | Uniprot | |
| K578 | Ubiquitination | Uniprot | |
| K596 | Ubiquitination | Uniprot | |
| K614 | Ubiquitination | Uniprot | |
| K626 | Ubiquitination | Uniprot | |
| K655 | Ubiquitination | Uniprot | |
| S688 | Phosphorylation | Uniprot | |
| C715 | S-Nitrosylation | Uniprot | |
| S718 | Phosphorylation | Uniprot |
研究背景
Transcriptional regulator that acts as repressor or activator, depending on the context. Binds to NF-E2 DNA binding sites. Plays important roles in coordinating transcription activation and repression by MAFK (By similarity). Together with MAF, represses the transcription of genes under the control of the NFE2L2 oxidative stress pathway.
Ubiquitinated by the SCF(FBXL17) complex, leading to its degradation by the proteasome.
Nucleus.
Heterodimer of BACH1 and MAFK.
Belongs to the bZIP family. CNC subfamily.
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