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产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF8337, RRID:AB_2841605.
展开/折叠
B2; B2 bradykinin receptor; B2BKR; B2BRA; B2R; BDKR B2; BDKRB 2; BDKRB2; BK 2; BK 2 receptor; BK R2; BK-2 receptor; BK2; BK2 receptor; BK2R; BKR 2; BKR2; BKRB2_HUMAN; BR B2; Bradykinin receptor B2; Bradykinin receptor beta 2; BRB 2; BRB2; DKFZp686O088; Kinin B2;
抗原和靶标
- P30411 BKRB2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MFSPWKISMFLSVREDSVPTTASFSADMLNVTLQGPTLNGTFAQSKCPQVEWLGWLNTIQPPFLWVLFVLATLENIFVLSVFCLHKSSCTVAEIYLGNLAAADLILACGLPFWAITISNNFDWLFGETLCRVVNAIISMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLVIWGCTLLLSSPMLVFRTMKEYSDEGHNVTACVISYPSLIWEVFTNMLLNVVGFLLPLSVITFCTMQIMQVLRNNEMQKFKEIQTERRATVLVLVVLLLFIICWLPFQISTFLDTLHRLGILSSCQDERIIDVITQIASFMAYSNSCLNPLVYVIVGKRFRKKSWEVYQGVCQKGGCRSEPIQMENSMGTLRTSISVERQIHKLQDWAGSRQ
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P30411 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S17 | Phosphorylation | Uniprot | |
| T162 | Phosphorylation | Uniprot | |
| Y177 | Phosphorylation | P12931 (SRC) | Uniprot |
| S178 | Phosphorylation | Uniprot | |
| Y332 | Phosphorylation | Uniprot | |
| Y347 | Phosphorylation | P12931 (SRC) | Uniprot |
| S358 | Phosphorylation | Uniprot | |
| S366 | Phosphorylation | P32298 (GRK4) , P35626 (GRK3) , P25098 (GRK2) , P34947 (GRK5) , P43250 (GRK6) | Uniprot |
| S373 | Phosphorylation | P43250 (GRK6) , P25098 (GRK2) , P35626 (GRK3) , P17252 (PRKCA) , Q05655 (PRKCD) , P32298 (GRK4) , P34947 (GRK5) | Uniprot |
| S375 | Phosphorylation | P34947 (GRK5) , P35626 (GRK3) , P32298 (GRK4) , P25098 (GRK2) , P43250 (GRK6) | Uniprot |
| K382 | Ubiquitination | Uniprot |
研究背景
Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Cell membrane>Multi-pass membrane protein.
Ubiquitous. Widespread in normal smooth muscle tissue and neurons.
Forms a complex with PECAM1 and GNAQ. Interacts with PECAM1.
Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB2 sub-subfamily.
研究领域
· Cellular Processes > Cell motility > Regulation of actin cytoskeleton. (View pathway)
· Environmental Information Processing > Signal transduction > Calcium signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > cGMP-PKG signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Sphingolipid signaling pathway. (View pathway)
· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.
· Human Diseases > Infectious diseases: Parasitic > Chagas disease (American trypanosomiasis).
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
· Organismal Systems > Immune system > Complement and coagulation cascades. (View pathway)
· Organismal Systems > Sensory system > Inflammatory mediator regulation of TRP channels. (View pathway)
· Organismal Systems > Excretory system > Endocrine and other factor-regulated calcium reabsorption.
文献引用
Application: WB Species: human Sample: HUVECs and HEK293 cells
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