SPTBN1 Antibody - #DF8341

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产品: SPTBN1 抗体
货号: DF8341
描述: Rabbit polyclonal antibody to SPTBN1
应用: WB IF/ICC
反应: Human, Mouse, Rat
预测: Pig, Bovine, Sheep, Rabbit, Dog
分子量: 275 kDa; 275kD(Calculated).
蛋白号: Q01082
RRID: AB_2841609

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MSDS
说明书
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实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:1000-3000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Pig(100%), Bovine(100%), Sheep(100%), Rabbit(100%), Dog(100%)
克隆:
Polyclonal
特异性:
SPTBN1 Antibody detects endogenous levels of total SPTBN1.
RRID:
AB_2841609
引用格式: Affinity Biosciences Cat# DF8341, RRID:AB_2841609.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Beta G spectrin; Beta II spectrin; Beta spectrin 2; Beta spectrin II; Beta-II spectrin; betaSpII; brain 1; ELF; Embryonic liver beta fodrin; Fodrin beta chain; non-erythroid beta chain 1; Spectrin; Spectrin beta chain; Spectrin, beta, non erythrocytic 1; Spectrin, non erythroid beta chain 1; SPTB2; SPTB2_HUMAN; SPTBN1;

抗原和靶标

免疫原:
Uniprot:

Q01082(SPTB2_HUMAN) >>Visit HPA database.

基因/基因ID:
SPTBN1(6711)
表达:
Q01082 SPTB2_HUMAN:

Isoform 2 is present in brain, lung and kidney (at protein level).

序列:
MTTTVATDYDNIEIQQQYSDVNNRWDVDDWDNENSSARLFERSRIKALADEREAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPTKGRMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSNAHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRPPSPEPSTKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRMAETVDTSEMVNGATEQRTSSKESSPIPSPTSDRKAKTALPAQSAATLPARTQETPSAQMEGFLNRKHEWEAHNKKASSRSWHNVYCVINNQEMGFYKDAKTAASGIPYHSEVPVSLKEAVCEVALDYKKKKHVFKLRLNDGNEYLFQAKDDEEMNTWIQAISSAISSDKHEVSASTQSTPASSRAQTLPTSVVTITSESSPGKREKDKEKDKEKRFSLFGKKK

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Pig
100
Bovine
100
Sheep
100
Dog
100
Rabbit
100
Horse
0
Xenopus
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q01082 作为底物

Site PTM Type Enzyme
T2 Acetylation
Y9 Phosphorylation
Y18 Phosphorylation
K62 Ubiquitination
Y79 Phosphorylation
T80 Phosphorylation
K90 Acetylation
S96 Phosphorylation
K105 Ubiquitination
K118 Acetylation
K118 Ubiquitination
K124 Acetylation
K124 Ubiquitination
S163 Phosphorylation
K214 Sumoylation
K214 Ubiquitination
K224 Ubiquitination
K227 Ubiquitination
S228 Phosphorylation
K249 Ubiquitination
S257 Phosphorylation
Y274 Phosphorylation
S278 Phosphorylation
K288 Ubiquitination
K292 Ubiquitination
S333 Phosphorylation
K359 Ubiquitination
Y381 Phosphorylation
K387 Ubiquitination
K419 Ubiquitination
K462 Ubiquitination
K463 Ubiquitination
T469 Phosphorylation
Y474 Phosphorylation
Y493 Phosphorylation
K497 Acetylation
K497 Ubiquitination
K558 Ubiquitination
K593 Ubiquitination
K602 Ubiquitination
Y620 Phosphorylation
K659 Ubiquitination
S662 Phosphorylation
Y666 Phosphorylation
K668 Ubiquitination
R681 Methylation
K714 Ubiquitination
Y721 Phosphorylation
S770 Phosphorylation
Y777 Phosphorylation
S778 Phosphorylation
T779 Phosphorylation
S781 Phosphorylation
K784 Ubiquitination
Y796 Phosphorylation
S817 Phosphorylation
S825 Phosphorylation
Y831 Phosphorylation
K832 Ubiquitination
T838 Phosphorylation
K842 Ubiquitination
S856 Phosphorylation
K924 Acetylation
K924 Ubiquitination
S938 Phosphorylation
K976 Ubiquitination
K997 Ubiquitination
T999 Phosphorylation
K1011 Ubiquitination
S1013 Phosphorylation
K1021 Ubiquitination
S1041 Phosphorylation
T1049 Phosphorylation
S1057 Phosphorylation
S1076 Phosphorylation
S1079 Phosphorylation
T1095 Phosphorylation
K1099 Ubiquitination
K1108 Ubiquitination
Y1114 Phosphorylation
Y1118 Phosphorylation
Y1137 Phosphorylation
S1168 Phosphorylation
Y1171 Phosphorylation
K1209 Ubiquitination
T1216 Phosphorylation
T1217 Phosphorylation
R1233 Methylation
S1237 Phosphorylation
S1243 Phosphorylation
R1245 Methylation
K1249 Ubiquitination
K1259 Sumoylation
T1263 Phosphorylation
K1272 Sumoylation
S1302 Phosphorylation
Y1303 Phosphorylation
K1335 Ubiquitination
K1360 Ubiquitination
K1372 Ubiquitination
K1381 Ubiquitination
S1388 Phosphorylation
K1394 Ubiquitination
S1401 Phosphorylation
S1405 Phosphorylation
K1421 Ubiquitination
K1434 Ubiquitination
S1447 Phosphorylation
K1451 Ubiquitination
T1462 Phosphorylation
K1478 Ubiquitination
K1485 Acetylation
K1485 Ubiquitination
K1532 Ubiquitination
S1557 Phosphorylation
S1559 Phosphorylation
K1571 Ubiquitination
K1633 Ubiquitination
Y1644 Phosphorylation
T1647 Phosphorylation
K1653 Acetylation
K1653 Ubiquitination
S1666 Phosphorylation
S1670 Phosphorylation
K1678 Ubiquitination
Y1680 Phosphorylation
K1684 Ubiquitination
Y1730 Phosphorylation
T1734 Phosphorylation
S1804 Phosphorylation
Y1805 Phosphorylation
K1809 Acetylation
Y1811 Phosphorylation
K1815 Acetylation
K1815 Ubiquitination
K1878 Ubiquitination
S1902 Phosphorylation
K1913 Acetylation
S1966 Phosphorylation
Y1983 Phosphorylation
S1985 Phosphorylation
K1989 Acetylation
K1991 Ubiquitination
T1996 Phosphorylation
Y2039 Phosphorylation
S2041 Phosphorylation
S2042 Phosphorylation
S2048 Phosphorylation
K2064 Ubiquitination
R2072 Methylation
T2080 Phosphorylation
T2081 Phosphorylation
S2102 Phosphorylation
S2106 Phosphorylation
T2107 Phosphorylation
S2110 Phosphorylation P68400 (CSNK2A1)
S2115 Phosphorylation
T2121 Phosphorylation
K2123 Ubiquitination
S2128 Phosphorylation
S2138 Phosphorylation
T2147 Phosphorylation
S2148 Phosphorylation
T2155 Phosphorylation
T2159 Phosphorylation P17612 (PRKACA) , P68400 (CSNK2A1)
S2160 Phosphorylation
S2161 Phosphorylation
S2164 Phosphorylation
S2165 Phosphorylation
S2169 Phosphorylation
T2171 Phosphorylation
S2172 Phosphorylation
K2177 Ubiquitination
S2184 Phosphorylation
T2187 Phosphorylation
T2195 Phosphorylation
K2207 Ubiquitination
S2221 Phosphorylation
K2241 Ubiquitination
Y2249 Phosphorylation
S2251 Phosphorylation
Y2268 Phosphorylation
K2269 Acetylation
K2270 Acetylation
K2276 Ubiquitination
Y2285 Phosphorylation
T2297 Phosphorylation
K2310 Ubiquitination
S2314 Phosphorylation
S2316 Phosphorylation
T2317 Phosphorylation
S2319 Phosphorylation
T2320 Phosphorylation
S2323 Phosphorylation
S2324 O-Glycosylation
S2324 Phosphorylation
T2328 Phosphorylation
T2331 Phosphorylation
S2332 Phosphorylation
T2335 Phosphorylation
T2337 Phosphorylation
S2338 Phosphorylation
S2340 Phosphorylation
S2341 Phosphorylation
K2344 Acetylation
K2344 Ubiquitination
S2358 Phosphorylation
K2362 Acetylation
K2363 Acetylation

研究背景

功能:

Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.

细胞定位:

Cytoplasm>Cytoskeleton. Cytoplasm>Myofibril>Sarcomere>M line.
Note: Colocalizes with ANK2 in a distinct intracellular compartment of neonatal cardiomyocytes.

Cell membrane>Peripheral membrane protein>Cytoplasmic side.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Isoform 2 is present in brain, lung and kidney (at protein level).

亚基结构:

Interacts with CAMSAP1. Interacts with ANK2. Interacts with CPNE4 (via VWFA domain) (By similarity). Like erythrocyte spectrin, the spectrin-like proteins are capable to form dimers which can further associate to tetramers (By similarity). Isoform Short cannot bind to the axonal protein fodaxin.

蛋白家族:

Belongs to the spectrin family.

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