| 产品: | GSR 抗体 |
| 货号: | DF8471 |
| 描述: | Rabbit polyclonal antibody to GSR |
| 应用: | WB IHC |
| 反应: | Human, Rat |
| 预测: | Bovine, Horse, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 56 kDa; 56kD(Calculated). |
| 蛋白号: | P00390 |
| RRID: | AB_2841703 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF8471, RRID:AB_2841703.
展开/折叠
GLR1; GLUR; Glutathione reductase; Glutathione reductase mitochondrial; Glutathione reductase, mitochondrial; GR; Gr1; GRase; GRD 1; GRD1; GSHR_HUMAN; GSR; MGC78522;
抗原和靶标
- P00390 GSHR_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P00390 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y65 | Phosphorylation | Uniprot | |
| K97 | Acetylation | Uniprot | |
| K97 | Ubiquitination | Uniprot | |
| C107 | S-Nitrosylation | Uniprot | |
| K110 | Acetylation | Uniprot | |
| Y158 | Phosphorylation | Uniprot | |
| K164 | Acetylation | Uniprot | |
| K164 | Ubiquitination | Uniprot | |
| K181 | Ubiquitination | Uniprot | |
| K189 | Acetylation | Uniprot | |
| K189 | Ubiquitination | Uniprot | |
| K190 | Acetylation | Uniprot | |
| C278 | S-Nitrosylation | Uniprot | |
| K291 | Ubiquitination | Uniprot | |
| K296 | Ubiquitination | Uniprot | |
| K300 | Ubiquitination | Uniprot | |
| T301 | Phosphorylation | Uniprot | |
| S308 | Phosphorylation | Uniprot | |
| K340 | Ubiquitination | Uniprot | |
| K346 | Ubiquitination | Uniprot | |
| K354 | Ubiquitination | Uniprot | |
| K368 | Ubiquitination | Uniprot | |
| Y371 | Phosphorylation | Uniprot | |
| C377 | S-Nitrosylation | Uniprot | |
| K379 | Ubiquitination | Uniprot | |
| T383 | Phosphorylation | Uniprot | |
| K401 | Acetylation | Uniprot | |
| K401 | Ubiquitination | Uniprot | |
| K405 | Ubiquitination | Uniprot | |
| Y408 | Phosphorylation | Uniprot | |
| T427 | Phosphorylation | Uniprot | |
| K434 | Ubiquitination | Uniprot | |
| K441 | Ubiquitination | Uniprot | |
| S446 | Phosphorylation | Uniprot | |
| T448 | Phosphorylation | Uniprot | |
| Y451 | Phosphorylation | Uniprot | |
| T455 | Phosphorylation | Uniprot | |
| K456 | Acetylation | Uniprot | |
| K456 | Ubiquitination | Uniprot | |
| K464 | Ubiquitination | Uniprot | |
| K470 | Acetylation | Uniprot | |
| K470 | Ubiquitination | Uniprot | |
| C484 | S-Nitrosylation | Uniprot | |
| K501 | Ubiquitination | Uniprot | |
| T507 | Phosphorylation | Uniprot | |
| T513 | Phosphorylation | Uniprot | |
| S514 | Phosphorylation | Uniprot | |
| S515 | Phosphorylation | Uniprot | |
| R522 | Methylation | Uniprot |
研究背景
Maintains high levels of reduced glutathione in the cytosol.
Mitochondrion.
Cytoplasm.
Homodimer; disulfide-linked.
Each subunit can be divided into 4 domains that are consecutive along the polypeptide chain. Domains 1 and 2 bind FAD and NADPH, respectively. Domain 4 forms the interface.
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
研究领域
· Metabolism > Metabolism of other amino acids > Glutathione metabolism.
· Organismal Systems > Endocrine system > Thyroid hormone synthesis.
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