| 产品: | ALDH3A1 抗体 |
| 货号: | DF8502 |
| 描述: | Rabbit polyclonal antibody to ALDH3A1 |
| 应用: | WB IHC |
| 反应: | Human, Rat |
| 预测: | Pig, Bovine, Horse, Dog |
| 分子量: | 50 kDa; 50kD(Calculated). |
| 蛋白号: | P30838 |
| RRID: | AB_2841708 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF8502, RRID:AB_2841708.
展开/折叠
Acetaldehyde dehydrogenase 3; AHD 4; AHD C; AHD4; AHDC; AL3A1_HUMAN; Aldehyde dehydrogenase 3; Aldehyde dehydrogenase 3 family member A1; Aldehyde dehydrogenase 3A1; Aldehyde dehydrogenase; Aldehyde dehydrogenase class 3; Aldehyde dehydrogenase dimeric NADP preferring; Aldehyde dehydrogenase family 3 member A1; Aldehyde dehydrogenase family 3 subfamily A1; Aldehyde dehydrogenase family 3, subfamily A, member 1; Aldehyde dehydrogenase isozyme 3; Aldehyde dehydrogenase type III; ALDH 3; ALDH 3A1; ALDH III; ALDH, stomach type; ALDH3 A1; ALDH3; ALDH3A 1; Aldh3a1; ALDHIII; dimeric NADP-preferring; MGC10406; Stomach aldehyde dehydrogenase; Tumor associated aldehyde dehydrogenase tumor ALDH;
抗原和靶标
- P30838 AL3A1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEGQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P30838 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Acetylation | Uniprot | |
| K3 | Acetylation | Uniprot | |
| S5 | Phosphorylation | Uniprot | |
| Y163 | Phosphorylation | Uniprot | |
| K178 | Acetylation | Uniprot | |
| K178 | Ubiquitination | Uniprot | |
| Y186 | Phosphorylation | Uniprot | |
| K194 | Acetylation | Uniprot | |
| T198 | Phosphorylation | Uniprot | |
| K202 | Acetylation | Uniprot | |
| T205 | Phosphorylation | Uniprot | |
| K214 | Ubiquitination | Uniprot | |
| K221 | Ubiquitination | Uniprot | |
| K269 | Acetylation | Uniprot | |
| K269 | Ubiquitination | Uniprot | |
| Y272 | Phosphorylation | Uniprot | |
| K277 | Ubiquitination | Uniprot | |
| K302 | Ubiquitination | Uniprot | |
| Y305 | Phosphorylation | Uniprot | |
| S399 | Phosphorylation | Uniprot | |
| Y443 | Phosphorylation | Uniprot | |
| S446 | Phosphorylation | Uniprot |
研究背景
ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids. Preferentially oxidizes aromatic aldehyde substrates. Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity).
Cytoplasm.
High levels in stomach, esophagus and lung; low level in the liver and kidney.
Homodimer.
Belongs to the aldehyde dehydrogenase family.
研究领域
· Human Diseases > Cancers: Overview > Chemical carcinogenesis.
· Metabolism > Carbohydrate metabolism > Glycolysis / Gluconeogenesis.
· Metabolism > Amino acid metabolism > Histidine metabolism.
· Metabolism > Amino acid metabolism > Tyrosine metabolism.
· Metabolism > Amino acid metabolism > Phenylalanine metabolism.
· Metabolism > Metabolism of other amino acids > beta-Alanine metabolism.
· Metabolism > Xenobiotics biodegradation and metabolism > Metabolism of xenobiotics by cytochrome P450.
· Metabolism > Xenobiotics biodegradation and metabolism > Drug metabolism - cytochrome P450.
· Metabolism > Global and overview maps > Metabolic pathways.
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