| 产品: | BRCAA1 抗体 |
| 货号: | DF8508 |
| 描述: | Rabbit polyclonal antibody to BRCAA1 |
| 应用: | WB |
| 反应: | Human, Mouse, Rat |
| 预测: | Bovine, Horse, Rabbit, Dog |
| 分子量: | 147 kDa; 148kD(Calculated). |
| 蛋白号: | Q4LE39 |
| RRID: | AB_2841714 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF8508, RRID:AB_2841714.
展开/折叠
ARID 4B; ARID domain-containing protein 4B; ARID4B; AT rich interactive domain 4B (Rbp1 like); AT rich interactive domain 4B; BCAA; BRCAA 1; BRCAA1; Breast cancer associated antigen 1; Breast cancer associated antigen BRCAA 1; Breast cancer associated antigen BRCAA1; Breast carcinoma associated antigen; DKFZp313M2420; Histone deacetylase complex subunit SAP180; MGC163290; Rb binding protein homolog; RBBP1 L1; RBBP1L1; Rbp 1 like; Rbp1 l1; Rbp1 like; RBP1 like protein; RBP1L; Rbp1l1; Retinoblastoma binding protein 1 like 1; SAP 180; SAP180; SIN3A associated protein 180;
抗原和靶标
Highly expressed in the testis and in breast, lung, colon, pancreatic and ovarian cancers. Expressed at low levels in the thymus, prostate and ovary.
- Q4LE39 ARI4B_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MKALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKVTFRHDSSTVEVQDDHIKGPLKVGAIVEVKNLDGAYQEAVINKLTDASWYTVVFDDGDEKTLRRSSLCLKGERHFAESETLDQLPLTNPEHFGTPVIGKKTNRGRRSNHIPEEESSSSSSDEDEDDRKQIDELLGKVVCVDYISLDKKKALWFPALVVCPDCSDEIAVKKDNILVRSFKDGKFTSVPRKDVHEITSDTAPKPDAVLKQAFEQALEFHKSRTIPANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEIEPFPEERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIEFQMALPEKVVNKQCKECENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEIERKENIKPSLGSKKNLLESIPTHSDQEKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAKSGDETNKEEDEDDEEAEEEEEEEEEEEDEDDDDNNEEEEFECYPPGMKVQVRYGRGKNQKMYEASIKDSDVEGGEVLYLVHYCGWNVRYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSNSSSDEDEEETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPAPEEGVAEESLQTVAEEESCSPSVELEKPPPVNVDSKPIEEKTVEVNDRKAEFPSSGSNSVLNTPPTTPESPSSVTVTEGSRQQSSVTVSEPLAPNQEEVRSIKSETDSTIEVDSVAGELQDLQSEGNSSPAGFDASVSSSSSNQPEPEHPEKACTGQKRVKDAQGGGSSSKKQKRSHKATVVNNKKKGKGTNSSDSEELSAGESITKSQPVKSVSTGMKSHSTKSPARTQSPGKCGKNGDKDPDLKEPSNRLPKVYKWSFQMSDLENMTSAERITILQEKLQEIRKHYLSLKSEVASIDRRRKRLKKKERESAATSSSSSSPSSSSITAAVMLTLAEPSMSSASQNGMSVECR
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q4LE39 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K28 | Ubiquitination | Uniprot | |
| K57 | Ubiquitination | Uniprot | |
| Y89 | Phosphorylation | Uniprot | |
| T90 | Phosphorylation | Uniprot | |
| S105 | Phosphorylation | Uniprot | |
| T126 | Phosphorylation | Uniprot | |
| T133 | Phosphorylation | Uniprot | |
| K257 | Ubiquitination | Uniprot | |
| S273 | Phosphorylation | Uniprot | |
| S275 | Phosphorylation | Uniprot | |
| S276 | Phosphorylation | Uniprot | |
| S295 | Phosphorylation | Uniprot | |
| S296 | Phosphorylation | Uniprot | |
| Y335 | Phosphorylation | Uniprot | |
| K429 | Sumoylation | Uniprot | |
| K440 | Sumoylation | Uniprot | |
| K466 | Ubiquitination | Uniprot | |
| S471 | Phosphorylation | Uniprot | |
| S483 | Phosphorylation | Uniprot | |
| T507 | Phosphorylation | Uniprot | |
| T508 | Phosphorylation | Uniprot | |
| K647 | Acetylation | Uniprot | |
| K649 | Acetylation | Uniprot | |
| K654 | Acetylation | Uniprot | |
| Y655 | Phosphorylation | Uniprot | |
| S656 | Phosphorylation | Uniprot | |
| S666 | Phosphorylation | Uniprot | |
| T672 | Phosphorylation | Uniprot | |
| S675 | Phosphorylation | Uniprot | |
| K688 | Ubiquitination | Uniprot | |
| S717 | Phosphorylation | Uniprot | |
| K751 | Ubiquitination | Uniprot | |
| S758 | Phosphorylation | Uniprot | |
| S776 | Phosphorylation | Uniprot | |
| S778 | Phosphorylation | Uniprot | |
| S790 | Phosphorylation | Uniprot | |
| T793 | Phosphorylation | Uniprot | |
| Y795 | Phosphorylation | Uniprot | |
| Y827 | Phosphorylation | Uniprot | |
| T830 | Phosphorylation | Uniprot | |
| T836 | Phosphorylation | Uniprot | |
| S838 | Phosphorylation | Uniprot | |
| T874 | Phosphorylation | Uniprot | |
| K878 | Acetylation | Uniprot | |
| S888 | Phosphorylation | Uniprot | |
| Y895 | Phosphorylation | Uniprot | |
| S896 | Phosphorylation | Uniprot | |
| S899 | Phosphorylation | Uniprot | |
| K904 | Acetylation | Uniprot | |
| K904 | Ubiquitination | Uniprot | |
| S912 | Phosphorylation | Uniprot | |
| S919 | Phosphorylation | Uniprot | |
| S930 | Phosphorylation | Uniprot | |
| S1014 | Phosphorylation | Uniprot | |
| T1022 | Phosphorylation | Uniprot | |
| T1025 | Phosphorylation | Uniprot | |
| T1026 | Phosphorylation | Uniprot | |
| S1029 | Phosphorylation | Uniprot | |
| S1031 | Phosphorylation | Uniprot | |
| S1032 | Phosphorylation | Uniprot | |
| T1036 | Phosphorylation | Uniprot | |
| S1060 | Phosphorylation | Uniprot | |
| K1131 | Acetylation | Uniprot | |
| T1150 | Phosphorylation | Uniprot | |
| S1152 | Phosphorylation | Uniprot | |
| S1153 | Phosphorylation | Uniprot | |
| S1155 | Phosphorylation | Uniprot | |
| S1159 | Phosphorylation | Uniprot | |
| S1174 | Phosphorylation | Uniprot | |
| K1178 | Acetylation | Uniprot | |
| K1183 | Acetylation | Uniprot | |
| S1184 | Phosphorylation | Uniprot | |
| S1190 | Phosphorylation | Uniprot | |
| K1245 | Ubiquitination | Uniprot | |
| S1256 | Phosphorylation | Uniprot |
研究背景
Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A. Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity).
Nucleus. Cytoplasm.
Note: Cytoplasmic in breast cancer cells.
Highly expressed in the testis and in breast, lung, colon, pancreatic and ovarian cancers. Expressed at low levels in the thymus, prostate and ovary.
Component of a Sin3A corepressor complex consisting of SIN3A, SAP130, SUDS3/SAP45, SAP180, HDAC1 and HDAC2. Interacts with ARID4A. Interacts with AR (By similarity).
The C-terminus mediates interaction with mSin3A corepressor complex.
The N-terminus is involved in transcriptional repression by HDAC-independent mechanisms.
The ARID domain is involved in stabilizing the mSin3A corepressor complex on DNA.
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