产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF8525, RRID:AB_2841730.
展开/折叠
CTP synthase 1; CTP synthase; CTP synthetase 1; CTP synthetase; CTPS; Cytidine 5 prime triphosphate synthetase; Cytidine 5' triphosphate synthetase; IMD24; UTP ammonia ligase 1;
抗原和靶标
- P17812 PYRG1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MKYILVTGGVISGIGKGIIASSVGTILKSCGLHVTSIKIDPYINIDAGTFSPYEHGEVFVLDDGGEVDLDLGNYERFLDIRLTKDNNLTTGKIYQYVINKERKGDYLGKTVQVVPHITDAIQEWVMRQALIPVDEDGLEPQVCVIELGGTVGDIESMPFIEAFRQFQFKVKRENFCNIHVSLVPQPSSTGEQKTKPTQNSVRELRGLGLSPDLVVCRCSNPLDTSVKEKISMFCHVEPEQVICVHDVSSIYRVPLLLEEQGVVDYFLRRLDLPIERQPRKMLMKWKEMADRYDRLLETCSIALVGKYTKFSDSYASVIKALEHSALAINHKLEIKYIDSADLEPITSQEEPVRYHEAWQKLCSAHGVLVPGGFGVRGTEGKIQAIAWARNQKKPFLGVCLGMQLAVVEFSRNVLGWQDANSTEFDPTTSHPVVVDMPEHNPGQMGGTMRLGKRRTLFQTKNSVMRKLYGDADYLEERHRHRFEVNPVWKKCLEEQGLKFVGQDVEGERMEIVELEDHPFFVGVQYHPEFLSRPIKPSPPYFGLLLASVGRLSHYLQKGCRLSPRDTYSDRSGSSSPDSEITELKFPSINHD
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P17812 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S12 | Phosphorylation | Uniprot | |
| S22 | Phosphorylation | Uniprot | |
| Y53 | Phosphorylation | Uniprot | |
| R81 | Methylation | Uniprot | |
| K84 | Ubiquitination | Uniprot | |
| K92 | Acetylation | Uniprot | |
| K92 | Ubiquitination | Uniprot | |
| Y94 | Phosphorylation | Uniprot | |
| Y96 | Phosphorylation | Uniprot | |
| K100 | Acetylation | Uniprot | |
| K100 | Ubiquitination | Uniprot | |
| K103 | Ubiquitination | Uniprot | |
| Y106 | Phosphorylation | Uniprot | |
| K169 | Methylation | Uniprot | |
| K169 | Ubiquitination | Uniprot | |
| K171 | Acetylation | Uniprot | |
| K195 | Ubiquitination | Uniprot | |
| R205 | Methylation | Uniprot | |
| S210 | Phosphorylation | Uniprot | |
| K227 | Ubiquitination | Uniprot | |
| S231 | Phosphorylation | Uniprot | |
| Y265 | Phosphorylation | Uniprot | |
| K286 | Acetylation | Uniprot | |
| K286 | Ubiquitination | Uniprot | |
| K306 | Acetylation | Uniprot | |
| K306 | Ubiquitination | Uniprot | |
| Y307 | Phosphorylation | Uniprot | |
| K309 | Acetylation | Uniprot | |
| K309 | Ubiquitination | Uniprot | |
| K319 | Ubiquitination | Uniprot | |
| K331 | Ubiquitination | Uniprot | |
| K335 | Ubiquitination | Uniprot | |
| T346 | Phosphorylation | Uniprot | |
| S347 | Phosphorylation | Uniprot | |
| K360 | Ubiquitination | Uniprot | |
| C362 | S-Nitrosylation | Uniprot | |
| K381 | Ubiquitination | Uniprot | |
| R389 | Methylation | Uniprot | |
| T428 | Phosphorylation | Uniprot | |
| T447 | Phosphorylation | Uniprot | |
| T455 | Phosphorylation | P17612 (PRKACA) , P17252 (PRKCA) | Uniprot |
| K460 | Acetylation | Uniprot | |
| K460 | Ubiquitination | Uniprot | |
| S462 | Phosphorylation | P17252 (PRKCA) | Uniprot |
| K466 | Ubiquitination | Uniprot | |
| Y473 | Phosphorylation | Uniprot | |
| R477 | Methylation | Uniprot | |
| K489 | Methylation | Uniprot | |
| K489 | Ubiquitination | Uniprot | |
| K490 | Methylation | Uniprot | |
| K490 | Ubiquitination | Uniprot | |
| K498 | Ubiquitination | Uniprot | |
| K535 | Ubiquitination | Uniprot | |
| S552 | Phosphorylation | Uniprot | |
| K557 | Ubiquitination | Uniprot | |
| S562 | Phosphorylation | Uniprot | |
| T566 | Phosphorylation | Uniprot | |
| Y567 | Phosphorylation | Uniprot | |
| S568 | Phosphorylation | Uniprot | |
| R570 | Methylation | Uniprot | |
| S571 | Phosphorylation | P49840 (GSK3A) | Uniprot |
| S573 | Phosphorylation | Uniprot | |
| S574 | Phosphorylation | Uniprot | |
| S575 | Phosphorylation | Uniprot | |
| S578 | Phosphorylation | Uniprot | |
| T581 | Phosphorylation | Uniprot | |
| K584 | Ubiquitination | Uniprot | |
| S587 | Phosphorylation | Uniprot |
研究背景
This enzyme is involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. This enzyme and its product, CTP, play a crucial role in the proliferation of activated lymphocytes and therefore in immunity.
Widely expressed.
Belongs to the CTP synthase family.
研究领域
· Metabolism > Nucleotide metabolism > Pyrimidine metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
限制条款
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