| 产品: | ECP 抗体 |
| 货号: | DF8536 |
| 描述: | Rabbit polyclonal antibody to ECP |
| 应用: | WB IHC |
| 反应: | Human, Monkey |
| 分子量: | 18 kDa; 18kD(Calculated). |
| 蛋白号: | P12724 |
| RRID: | AB_2841740 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF8536, RRID:AB_2841740.
展开/折叠
Cytotoxic ribonuclease; ECP; ECP_HUMAN; Eosinophil cationic protein; OTTHUMP00000164017; Ribonuclease 3; Ribonuclease, RNase A family, 3; RNase 3; RNASE3; RNS3;
抗原和靶标
- P12724 ECP_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MVPKLFTSQICLLLLLGLMGVEGSLHARPPQFTRAQWFAIQHISLNPPRCTIAMRAINNYRWRCKNQNTFLRTTFANVVNVCGNQSIRCPHNRTLNNCHRSRFRVPLLHCDLINPGAQNISNCTYADRPGRRFYVVACDNRDPRDSPRYPVVPVHLDTTI
翻译修饰 - P12724 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y149 | Phosphorylation | Uniprot | |
| T158 | Phosphorylation | Uniprot | |
| T159 | Phosphorylation | Uniprot |
研究背景
Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content.
Secreted.
Note: Located in the matrix of eosinophil large specific granule, which are released following activation by an immune stimulus.
Interacts with bacterial lipopolysaccharide (LPS) and lipoteichoic acid (LTA). In vitro interacts with and insert into lipid bilayers composed of dioleoyl phosphatidylcholine and dioleoyl phosphatidylglycerol. In vitro, tends to form amyloid-like aggregates at pH 3, but not at pH 5, nor 7.
Belongs to the pancreatic ribonuclease family.
研究领域
· Human Diseases > Immune diseases > Asthma.
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