Erbin Antibody - #DF8544

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产品: Erbin 抗体
货号: DF8544
描述: Rabbit polyclonal antibody to Erbin
应用: WB IHC
反应: Human, Monkey
预测: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
分子量: 158 kDa; 158kD(Calculated).
蛋白号: Q96RT1
RRID: AB_2841748

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   规格 价格 库存
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MS Report
HPLC Report
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说明书
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WB Handbook
IHC Protocol
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产品描述

来源:
Rabbit
应用:
WB 1:1000-3000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Monkey
预测:
Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(100%)
克隆:
Polyclonal
特异性:
Erbin Antibody detects endogenous levels of total Erbin.
RRID:
AB_2841748
引用格式: Affinity Biosciences Cat# DF8544, RRID:AB_2841748.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Densin-180-like protein; Erbb2-interacting protein; Erbb2ip; Erbin; LAP2; LAP2_HUMAN; Protein LAP2;

抗原和靶标

免疫原:
Uniprot:

Q96RT1(ERBIN_HUMAN) >>Visit HPA database.

基因/基因ID:
ERBIN(55914)
表达:
Q96RT1 ERBIN_HUMAN:

Highly expressed in brain, heart, kidney, muscle and stomach, followed by liver, spleen and intestine.

序列:
MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNLKRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTTTVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEELSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSSPSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKFKAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEIMERSKTQDIVLGTSFLSINSKEETEHLENGNKYPNLESVNKVNGHSEETSQSPNRTEPHDSDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVKITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRGPTSGPQSAPQIYGPPQYNIQYSSSAAVKDTLWHSKQNPQIDHASFPPQLLPRSESTENQSYAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSVSSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNASRPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPRDWREQVLRHIEAKKLEKKHPQTSSSGDPCQDGIFISGQQNYSSATLSHKDVPPDSLMKMPLSNGQMGQPLRPQANYSQIHHPPQASVARHPSREQLIDYLMLKVAHQPPYTQPHCSPRQGHELAKQEIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKLLQPGDKIIQANGYSFINIEHGQAVSLLKTFQNTVELIIVREVSS

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Chicken
100
Rabbit
100
Xenopus
0
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q96RT1 作为底物

Site PTM Type Enzyme
K46 Ubiquitination
Y52 Phosphorylation
K63 Ubiquitination
K73 Ubiquitination
K101 Ubiquitination
K162 Ubiquitination
K178 Ubiquitination
T220 Phosphorylation
K230 Ubiquitination
S238 Phosphorylation
K369 Ubiquitination
K371 Ubiquitination
K381 Ubiquitination
K404 Ubiquitination
K411 Ubiquitination
K419 Ubiquitination
S440 Phosphorylation
S444 Phosphorylation
S448 Phosphorylation
Y483 Phosphorylation
T485 Phosphorylation
Y487 Phosphorylation
K492 Ubiquitination
K506 Sumoylation
K529 Ubiquitination
S538 Phosphorylation
Y552 Phosphorylation
S557 Phosphorylation
S562 Phosphorylation
S569 Phosphorylation
S572 Phosphorylation
S598 Phosphorylation
S602 Phosphorylation
S603 Phosphorylation
S620 Phosphorylation
S630 Phosphorylation
S662 Phosphorylation
K694 Ubiquitination
S704 Phosphorylation
S714 Phosphorylation
S715 Phosphorylation
T716 Phosphorylation
K719 Ubiquitination
K726 Ubiquitination
Y733 Phosphorylation
K769 Ubiquitination
S794 Phosphorylation
S797 Phosphorylation
S800 Phosphorylation
Y813 Phosphorylation
S818 Phosphorylation
S826 Phosphorylation
S832 Phosphorylation
S841 Phosphorylation
S844 Phosphorylation
S850 Phosphorylation
S852 Phosphorylation
T853 Phosphorylation
S857 Phosphorylation
K860 Ubiquitination
S866 Phosphorylation
S870 Phosphorylation
S872 Phosphorylation
T874 Phosphorylation
Y884 Phosphorylation
S888 Phosphorylation
K908 Ubiquitination
S913 Phosphorylation
K914 Ubiquitination
S915 Phosphorylation
T917 Phosphorylation
Y920 Phosphorylation
T928 Phosphorylation
S930 Phosphorylation
S931 Phosphorylation
S932 Phosphorylation
S933 Phosphorylation
S934 Phosphorylation
K945 Ubiquitination
Y972 Phosphorylation
Y977 Phosphorylation
Y981 Phosphorylation
S982 Phosphorylation
S983 Phosphorylation
S984 Phosphorylation
S994 Phosphorylation
S1015 Phosphorylation
Y1021 Phosphorylation
K1023 Ubiquitination
T1040 Phosphorylation
Y1042 Phosphorylation
S1060 Phosphorylation
T1073 Phosphorylation
S1078 Phosphorylation
S1079 Phosphorylation
S1081 Phosphorylation
S1082 Phosphorylation
S1085 Phosphorylation
S1093 Phosphorylation
T1094 Phosphorylation
Y1104 Phosphorylation
S1106 Phosphorylation
Y1107 Phosphorylation
T1116 Phosphorylation
Y1132 Phosphorylation
S1133 Phosphorylation
S1144 Phosphorylation
S1148 Phosphorylation
T1156 Phosphorylation
S1158 Phosphorylation
S1160 Phosphorylation
Y1164 Phosphorylation
S1165 Phosphorylation
T1167 Phosphorylation
S1170 Phosphorylation
S1179 Phosphorylation
S1182 Phosphorylation
Y1235 Phosphorylation
Y1270 Phosphorylation
S1271 Phosphorylation
S1286 Phosphorylation
Y1293 Phosphorylation
Y1304 Phosphorylation
T1305 Phosphorylation
S1310 Phosphorylation
K1319 Ubiquitination
K1367 Ubiquitination
Y1381 Phosphorylation
S1382 Phosphorylation

研究背景

功能:

Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state. Inhibits NOD2-dependent NF-kappa-B signaling and proinflammatory cytokine secretion.

细胞定位:

Cell junction>Hemidesmosome. Nucleus membrane. Basolateral cell membrane.
Note: Found in hemidesmosomes, which are cell-substrate adhesion complexes in stratified epithelia. In transfected cells, either diffusely distributed over the cytoplasm or concentrated at the basolateral membrane. Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes (By similarity).

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Highly expressed in brain, heart, kidney, muscle and stomach, followed by liver, spleen and intestine.

亚基结构:

Interacts with ERBB2, BPAG1 and ITGB4. May favor the localization of ERBB2, by restricting its presence to the basolateral membrane of epithelial cells. Also found to interact with ARVCF and delta catenin. Interacts (via C-terminus) with DST Isoform 3 (via N-terminus). Interacts with NOD2 (via CARD domain).

蛋白家族:

Belongs to the LAP (LRR and PDZ) protein family.

研究领域

· Organismal Systems > Immune system > NOD-like receptor signaling pathway.   (View pathway)

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