(1)
(3)
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF8598, RRID:AB_2841802.
展开/折叠
Dopamine receptor interacting protein 5; Dopamine receptor-interacting protein 5; DRIP 5; DRIP5; hRap1; MGC105533; RAP 1; RAP1 homolog; RAP1, yeast, homolog if; RAP1, yeast, homolog of; Repressor/activator protein 1 homolog; TE2IP_HUMAN; Telomeric Repeat Binding Factor 2 Interacting Protein; Telomeric repeat-binding factor 2-interacting protein 1; TERF2-interacting protein; TERF2-interacting telomeric protein 1; TERF2IP; TRF2 Interacting Telomeric Protein RAP1; TRF2 interacting telomeric RAP1 protein; TRF2-interacting telomeric protein 1; TRF2-interacting telomeric protein;
抗原和靶标
- Q9NYB0 TE2IP_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAEAMDLGKDPNGPTHSSTLFVRDDGSSMSFYVRPSPAKRRLSTLILHGGGTVCRVQEPGAVLLAQPGEALAEASGDFISTQYILDCVERNERLELEAYRLGPASAADTGSEAKPGALAEGAAEPEPQRHAGRIAFTDADDVAILTYVKENARSPSSVTGNALWKAMEKSSLTQHSWQSLKDRYLKHLRGQEHKYLLGDAPVSPSSQKLKRKAEEDPEAADSGEPQNKRTPDLPEEEYVKEEIQENEEAVKKMLVEATREFEEVVVDESPPDFEIHITMCDDDPPTPEEDSETQPDEEEEEEEEKVSQPEVGAAIKIIRQLMEKFNLDLSTVTQAFLKNSGELEATSAFLASGQRADGYPIWSRQDDIDLQKDDEDTREALVKKFGAQNVARRIEFRKK
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9NYB0 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| T15 | Phosphorylation | Uniprot | |
| Y32 | Phosphorylation | Uniprot | |
| S36 | Phosphorylation | Uniprot | |
| S43 | Phosphorylation | Uniprot | |
| T44 | Phosphorylation | Uniprot | |
| T52 | Phosphorylation | Uniprot | |
| C54 | S-Nitrosylation | Uniprot | |
| S105 | Phosphorylation | Uniprot | |
| T109 | Phosphorylation | Uniprot | |
| K114 | Ubiquitination | Uniprot | |
| K149 | Ubiquitination | Uniprot | |
| S154 | Phosphorylation | Uniprot | |
| S156 | Phosphorylation | Uniprot | |
| K169 | Ubiquitination | Uniprot | |
| S176 | Phosphorylation | Uniprot | |
| S179 | Phosphorylation | Uniprot | |
| K194 | Ubiquitination | Uniprot | |
| Y195 | Phosphorylation | Uniprot | |
| S203 | Phosphorylation | P24941 (CDK2) | Uniprot |
| S205 | Phosphorylation | Uniprot | |
| S206 | Phosphorylation | Uniprot | |
| K208 | Acetylation | Uniprot | |
| K208 | Ubiquitination | Uniprot | |
| S222 | Phosphorylation | Uniprot | |
| K228 | Ubiquitination | Uniprot | |
| T230 | Phosphorylation | Uniprot | |
| Y238 | Phosphorylation | Uniprot | |
| K240 | Sumoylation | Uniprot | |
| K240 | Ubiquitination | Uniprot | |
| K251 | Ubiquitination | Uniprot | |
| K252 | Ubiquitination | Uniprot | |
| T286 | Phosphorylation | Uniprot | |
| S291 | Phosphorylation | Uniprot | |
| K316 | Ubiquitination | Uniprot | |
| T377 | Phosphorylation | Uniprot | |
| K384 | Ubiquitination | Uniprot |
研究背景
Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes.
Nucleus. Cytoplasm. Chromosome. Chromosome>Telomere.
Note: Associates with chromosomes, both at telomeres and in extratelomeric sites. Also exists as a cytoplasmic form, where it associates with the IKK complex.
Ubiquitous. Highly expressed.
Associates with the I-kappa-B-kinase (IKK) core complex, composed of CHUK, IKBKB and IKBKG (By similarity). Homodimer. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP ACD and POT1. Interacts with TERF2; the interaction is direct. Does not interact with TERF1. Interacts with SLX4/BTBD12.
Belongs to the RAP1 family.
文献引用
Application: WB Species: rat Sample: HEI-OC1 cells
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