产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF8642, RRID:AB_2841846.
展开/折叠
Bcl10 binding protein and activator of NFKB; BIMP1; CAR10_HUMAN; CARD 10; CARD containing MAGUK 3 protein; CARD-containing MAGUK 3; CARD-containing MAGUK protein 3; CARD10; Carma 3; CARMA3; Caspase Recruitment Domain family member 10; Caspase recruitment domain-containing protein 10;
抗原和靶标
Detected in adult heart, kidney and liver; lower levels in intestine, placenta, muscle and lung. Also found in fetal lung, liver and kidney.
- Q9BWT7 CAR10_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPGRAEAGEAEEEAGAGSGSEAEEDALWERIEGVRHRLARALNPAKLTPYLRQCRVIDEQDEEEVLSTYRFPCRVNRTGRLMDILRCRGKRGYEAFLEALEFYYPEHFTLLTGQEPAQRCSMILDEEGPEGLTQFLMTEVRRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRRARGPPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEGLQQEASRPGAPGSERILLDILEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQYRKQVRGLEAERDELLTTLTSLEGTKALLEVQLQRAQGGTCLKACASSHSLCSNLSSTWSLSEFPSPLGGPEATGEAAVMGGPEPHNSEEATDSEKEINRLSILPFPPSAGSILRRQREEDPAPPKRSFSSMSDITGSVTLKPWSPGLSSSSSSDSVWPLGKPEGLLARGCGLDFLNRSLAIRVSGRSPPGGPEPQDKGPDGLSFYGDRWSGAVVRRVLSGPGSARMEPREQRVEAAGLEGACLEAEAQQRTLLWNQGSTLPSLMDSKACQSFHEALEAWAKGPGAEPFYIRANLTLPERADPHALCVKAQEILRLVDSAYKRRQEWFCTRVDPLTLRDLDRGTVPNYQRAQQLLEVQEKCLPSSRHRGPRSNLKKRALDQLRLVRPKPVGAPAGDSPDQLLLEPCAEPERSLRPYSLVRPLLVSALRPVVLLPECLAPRLIRNLLDLPSSRLDFQVCPAESLSGEELCPSSAPGAPKAQPATPGLGSRIRAIQESVGKKHCLLELGARGVRELVQNEIYPIVIHVEVTEKNVREVRGLLGRPGWRDSELLRQCRGSEQVLWGLPCSWVQVPAHEWGHAEELAKVVRGRILQEQARLVWVECGSSRGCPSSSEA
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9BWT7 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S18 | Phosphorylation | Uniprot | |
| S20 | Phosphorylation | Uniprot | |
| R174 | Methylation | Uniprot | |
| K220 | Ubiquitination | Uniprot | |
| K270 | Ubiquitination | Uniprot | |
| K272 | Ubiquitination | Uniprot | |
| Y356 | Phosphorylation | Uniprot | |
| K416 | Ubiquitination | Uniprot | |
| K421 | Ubiquitination | Uniprot | |
| S527 | Phosphorylation | Uniprot | |
| S603 | Phosphorylation | Uniprot | |
| S606 | Phosphorylation | Uniprot | |
| K616 | Ubiquitination | Uniprot | |
| S638 | Phosphorylation | Uniprot | |
| S642 | Phosphorylation | Uniprot | |
| K727 | Ubiquitination | Uniprot | |
| K740 | Ubiquitination | Uniprot | |
| K778 | Ubiquitination | Uniprot | |
| S830 | Phosphorylation | Uniprot | |
| Y834 | Phosphorylation | Uniprot | |
| T901 | Phosphorylation | Uniprot | |
| K917 | Ubiquitination | Uniprot | |
| K918 | Ubiquitination | Uniprot | |
| K949 | Ubiquitination | Uniprot |
研究背景
Activates NF-kappa-B via BCL10 and IKK.
Cytoplasm.
Detected in adult heart, kidney and liver; lower levels in intestine, placenta, muscle and lung. Also found in fetal lung, liver and kidney.
CARD10 and BCL10 bind to each other by CARD-CARD interaction. They both participate in a complex with MALT1, where MALT1 binds to BCL10 (By similarity).
研究领域
· Environmental Information Processing > Signal transduction > NF-kappa B signaling pathway. (View pathway)
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