CCRL2 Antibody - #DF8643
| 产品: | CCRL2 抗体 |
| 货号: | DF8643 |
| 描述: | Rabbit polyclonal antibody to CCRL2 |
| 应用: | WB IF/ICC |
| 反应: | Human, Rat |
| 预测: | Pig, Sheep, Dog |
| 分子量: | 39 kDa; 40kD(Calculated). |
| 蛋白号: | O00421 |
| RRID: | AB_2841847 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF8643, RRID:AB_2841847.
展开/折叠
C-C chemokine receptor-like 2; CCRL2; CCRL2_HUMAN; Chemokine (C-C motif) receptor like 2; Chemokine receptor CCR11; Chemokine receptor X; CKRX; CRAM A; CRAM B; CRAMA; CRAMB; FLJ55815; HCR; MGC116710; MGC34104; Putative MCP 1 chemokine receptor; Putative MCP-1 chemokine receptor;
抗原和靶标
Expressed abundantly in immunal tissues such as spleen, fetal liver, lymph node and bone marrow. Strong expression also in lung and heart. Expressed in almost all hematopoietic cells including monocytes, macrophages, PMNs, T-cells (both CD4+ and CD8+), monocyte-derived iDCs, NK cells, and CD34+ progenitor cells. B-cells expressed isoform 1 but not isoform 2. Up-regulated on synovial neutrophils of rheumatoid arthritis patients.
- O00421 CCRL2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MANYTLAPEDEYDVLIEGELESDEAEQCDKYDAQALSAQLVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHAGGDPMCKILIGLYFVGLYSETFFNCLLTVQRYLVFLHKGNFFSARRRVPCGIITSVLAWVTAILATLPEFVVYKPQMEDQKYKCAFSRTPFLPADETFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLRFREQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKEHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYLCRCFHLRSNTPLQPRGQSAQGTSREEPDHSTEV
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - O00421 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S83 | Phosphorylation | Uniprot | |
| K104 | Sumoylation | Uniprot | |
| Y170 | Phosphorylation | Uniprot | |
| T321 | Phosphorylation | Uniprot | |
| S329 | Phosphorylation | Uniprot | |
| T333 | Phosphorylation | Uniprot | |
| S341 | Phosphorylation | Uniprot | |
| T342 | Phosphorylation | Uniprot |
研究背景
Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors. Plays a critical role for the development of Th2 responses.
Cell membrane>Multi-pass membrane protein.
Expressed abundantly in immunal tissues such as spleen, fetal liver, lymph node and bone marrow. Strong expression also in lung and heart. Expressed in almost all hematopoietic cells including monocytes, macrophages, PMNs, T-cells (both CD4+ and CD8+), monocyte-derived iDCs, NK cells, and CD34+ progenitor cells. B-cells expressed isoform 1 but not isoform 2. Up-regulated on synovial neutrophils of rheumatoid arthritis patients.
Lacks the conserved DRYLAIV motif in the second intracellular loop that is required for signaling of functional chemokine receptors.
Belongs to the G-protein coupled receptor 1 family.
限制条款
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