FAF1 Antibody - #DF8655

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产品: FAF1 抗体
货号: DF8655
描述: Rabbit polyclonal antibody to FAF1
应用: WB IF/ICC
反应: Human, Mouse, Rat
预测: Pig, Zebrafish, Bovine, Horse, Sheep, Dog, Chicken
分子量: 73 kDa; 74kD(Calculated).
蛋白号: Q9UNN5
RRID: AB_2841859

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   规格 价格 库存
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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MS Report
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说明书
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实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:1000-3000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Pig(100%), Zebrafish(100%), Bovine(91%), Horse(100%), Sheep(100%), Dog(100%), Chicken(80%)
克隆:
Polyclonal
特异性:
FAF1 Antibody detects endogenous levels of total FAF1.
RRID:
AB_2841859
引用格式: Affinity Biosciences Cat# DF8655, RRID:AB_2841859.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

CGI 03; FAF1; FAF1 protein; FAF1_HUMAN; Fas (TNFRSF6) associated factor 1; FAS associated factor 1; Fas associated protein factor 1; FAS-associated factor 1; FLJ37524; hFAF1; HFAF1s; Protein FAF1; TNFRSF6 associated factor 1; UBX domain protein 3A; UBX domain-containing protein 12; UBX domain-containing protein 3A; UBXD12; UBXN3A;

抗原和靶标

免疫原:
Uniprot:

Q9UNN5(FAF1_HUMAN) >>Visit HPA database.

基因/基因ID:
FAF1(11124)
表达:
Q9UNN5 FAF1_HUMAN:

Most abundant in testis, slightly less abundant in skeletal muscle and heart, followed by prostate, thymus, ovary, small intestine, and colon. Not detected in the peripheral blood leukocytes.

序列:
MASNMDREMILADFQACTGIENIDEAITLLEQNNWDLVAAINGVIPQENGILQSEYGGETIPGPAFNPASHPASAPTSSSSSAFRPVMPSRQIVERQPRMLDFRVEYRDRNVDVVLEDTCTVGEIKQILENELQIPVSKMLLKGWKTGDVEDSTVLKSLHLPKNNSLYVLTPDLPPPSSSSHAGALQESLNQNFMLIITHREVQREYNLNFSGSSTIQEVKRNVYDLTSIPVRHQLWEGWPTSATDDSMCLAESGLSYPCHRLTVGRRSSPAQTREQSEEQITDVHMVSDSDGDDFEDATEFGVDDGEVFGMASSALRKSPMMPENAENEGDALLQFTAEFSSRYGDCHPVFFIGSLEAAFQEAFYVKARDRKLLAIYLHHDESVLTNVFCSQMLCAESIVSYLSQNFITWAWDLTKDSNRARFLTMCNRHFGSVVAQTIRTQKTDQFPLFLIIMGKRSSNEVLNVIQGNTTVDELMMRLMAAMEIFTAQQQEDIKDEDEREARENVKREQDEAYRLSLEADRAKREAHEREMAEQFRLEQIRKEQEEEREAIRLSLEQALPPEPKEENAEPVSKLRIRTPSGEFLERRFLASNKLQIVFDFVASKGFPWDEYKLLSTFPRRDVTQLDPNKSLLEVKLFPQETLFLEAKE

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Pig
100
Horse
100
Sheep
100
Dog
100
Zebrafish
100
Bovine
91
Chicken
80
Xenopus
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q9UNN5 作为底物

Site PTM Type Enzyme
K139 Ubiquitination
K143 Ubiquitination
K146 Acetylation
K146 Ubiquitination
K157 Acetylation
K157 Ubiquitination
K163 Ubiquitination
K221 Ubiquitination
Y225 Phosphorylation
T264 Phosphorylation
S269 Phosphorylation
S270 Phosphorylation
T274 Phosphorylation
S289 Phosphorylation P68400 (CSNK2A1) , O14965 (AURKA)
S291 Phosphorylation O14965 (AURKA) , P68400 (CSNK2A1)
K319 Ubiquitination
S320 Phosphorylation
S342 Phosphorylation
S343 Phosphorylation
K444 Ubiquitination
K457 Ubiquitination
K508 Sumoylation
K544 Ubiquitination
S556 Phosphorylation
K566 Ubiquitination
K575 Ubiquitination
T580 Phosphorylation
S582 Phosphorylation
K631 Ubiquitination
K637 Ubiquitination

研究背景

功能:

Ubiquitin-binding protein. Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation. Potentiates but cannot initiate FAS-induced apoptosis (By similarity).

细胞定位:

Nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Most abundant in testis, slightly less abundant in skeletal muscle and heart, followed by prostate, thymus, ovary, small intestine, and colon. Not detected in the peripheral blood leukocytes.

亚基结构:

Interacts with CDT1 and ATPase VCP/p97. Interacts (via UBA domain) with FAS (via death domain). Interacts (via UBA domain) with NLRP12 (via DAPIN/PYRIN domain).

研究领域

· Cellular Processes > Cell growth and death > Necroptosis.   (View pathway)

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