hnRNP H Antibody - #DF8667

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产品: hnRNP H 抗体
货号: DF8667
描述: Rabbit polyclonal antibody to hnRNP H
应用: WB
反应: Human, Mouse, Rat
预测: Pig, Bovine, Horse, Sheep, Rabbit, Dog
分子量: 49 kDa; 49kD(Calculated).
蛋白号: P31943 | P55795
RRID: AB_2841871

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   规格 价格 库存
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:1000-3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%)
克隆:
Polyclonal
特异性:
hnRNP H Antibody detects endogenous levels of total hnRNP H.
RRID:
AB_2841871
引用格式: Affinity Biosciences Cat# DF8667, RRID:AB_2841871.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

DKFZp686A15170; Heterogeneous nuclear ribonucleoprotein H; Heterogeneous nuclear ribonucleoprotein H1 (H); Heterogeneous nuclear ribonucleoprotein H1; HNRH1_HUMAN; hnRNP H; hnRNPH; Hnrnph1; HNRPH 1; HNRPH; HNRPH1 protein; N-terminally processed; FTP 3; FTP-3; FTP3; Heterogeneous nuclear ribonucleoprotein H''; heterogeneous nuclear ribonucleoprotein H2 (H'); Heterogeneous nuclear ribonucleoprotein H2; HNRH2_HUMAN; hnRNP H''; hnRNP H2; hnRNPH'; HNRNPH2; HNRPH'; HNRPH2;

抗原和靶标

免疫原:
Uniprot:

P31943(HNRH1_HUMAN) >>Visit HPA database.

P55795(HNRH2_HUMAN) >>Visit HPA database.

基因/基因ID:
HNRNPH2(3188) | HNRNPH1(3187)
表达:
P31943 HNRH1_HUMAN:

Expressed ubiquitously.

P55795 HNRH2_HUMAN:

Expressed ubiquitously.

序列:
MMLGTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNNVEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGLEIVPNGITLPVDFQGRSTGEAFVQFASQEIAEKALKKHKERIGHRYIEIFKSSRAEVRTHYDPPRKLMAMQRPGPYDRPGAGRGYNSIGRGAGFERMRRGAYGGGYGGYDDYNGYNDGYGFGSDRFGRDLNYCFSGMSDHRYGDGGSTFQSTTGHCVHMRGLPYRATENDIYNFFSPLNPVRVHIEIGPDGRVTGEADVEFATHEDAVAAMSKDKANMQHRYVELFLNSTAGASGGAYEHRYVELFLNSTAGASGGAYGSQMMGGMGLSNQSSYGGPASQQLSGGYGGGYGGQSSMSGYDQVLQENSSDFQSNIA

MMLSTEGREGFVVKVRGLPWSCSADEVMRFFSDCKIQNGTSGIRFIYTREGRPSGEAFVELESEEEVKLALKKDRETMGHRYVEVFKSNSVEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGLEIVPNGMTLPVDFQGRSTGEAFVQFASQEIAEKALKKHKERIGHRYIEIFKSSRAEVRTHYDPPRKLMAMQRPGPYDRPGAGRGYNSIGRGAGFERMRRGAYGGGYGGYDDYGGYNDGYGFGSDRFGRDLNYCFSGMSDHRYGDGGSSFQSTTGHCVHMRGLPYRATENDIYNFFSPLNPMRVHIEIGPDGRVTGEADVEFATHEDAVAAMAKDKANMQHRYVELFLNSTAGTSGGAYDHSYVELFLNSTAGASGGAYGSQMMGGMGLSNQSSYGGPASQQLSGGYGGGYGGQSSMSGYDQVLQENSSDYQSNLA

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Rabbit
100
Zebrafish
63
Xenopus
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - P31943/P55795 作为底物

Site PTM Type Enzyme
M1 Acetylation
S4 Phosphorylation
K14 Sumoylation
K14 Ubiquitination
S21 Phosphorylation
S23 Phosphorylation
K35 Sumoylation
K35 Ubiquitination
S63 Phosphorylation
K72 Sumoylation
K72 Ubiquitination
K73 Ubiquitination
R81 Methylation
K87 Ubiquitination
S90 Phosphorylation
K98 Methylation
K98 Sumoylation
K98 Ubiquitination
T100 Phosphorylation
S104 Phosphorylation P24941 (CDK2)
T107 Phosphorylation
R114 Methylation
S123 Phosphorylation
S161 Phosphorylation
K167 Acetylation
K167 Ubiquitination
K170 Ubiquitination
K171 Ubiquitination
Y180 Phosphorylation
K185 Acetylation
K185 Methylation
K185 Sumoylation
K185 Ubiquitination
S186 Phosphorylation
S187 Phosphorylation
T193 Phosphorylation
Y195 Phosphorylation
R199 Methylation
K200 Ubiquitination
R206 Methylation
Y210 Phosphorylation
R212 Methylation
R217 Methylation
Y219 Phosphorylation
S221 Phosphorylation
R224 Methylation
R230 Methylation
R232 Methylation
R233 Methylation
Y236 Phosphorylation
Y240 Phosphorylation
Y243 Phosphorylation
Y246 Phosphorylation
Y249 Phosphorylation
Y253 Phosphorylation
S257 Phosphorylation
R259 Methylation
Y266 Phosphorylation
S269 Phosphorylation
S272 Phosphorylation
R294 Methylation
Y298 Phosphorylation
Y306 Phosphorylation
S310 Phosphorylation
K349 Ubiquitination
Y376 Phosphorylation
S441 Phosphorylation
Site PTM Type Enzyme
M1 Acetylation
M2 Acetylation
T5 Phosphorylation
K14 Sumoylation
K14 Ubiquitination
S21 Phosphorylation
S23 Phosphorylation
R29 Methylation
C34 S-Nitrosylation
K35 Sumoylation
K35 Ubiquitination
R44 Methylation
Y47 Phosphorylation
S54 Phosphorylation
S63 Phosphorylation
K68 Sumoylation
K72 Sumoylation
R81 Methylation
K87 Sumoylation
K87 Ubiquitination
S88 Phosphorylation
K98 Acetylation
K98 Sumoylation
K98 Ubiquitination
T100 Phosphorylation
S104 Phosphorylation P28482 (MAPK1) , P24941 (CDK2)
T107 Phosphorylation
R114 Methylation
C122 S-Nitrosylation
S123 Phosphorylation
S151 Phosphorylation
T152 O-Glycosylation
S161 Phosphorylation
K167 Acetylation
K167 Ubiquitination
K170 Ubiquitination
K171 Ubiquitination
Y180 Phosphorylation
K185 Acetylation
K185 Methylation
K185 Sumoylation
K185 Ubiquitination
S186 Phosphorylation
S187 Phosphorylation
T193 Phosphorylation
Y195 Phosphorylation
R199 Methylation
K200 Ubiquitination
R206 Methylation
Y210 Phosphorylation
R212 Methylation
R217 Methylation
Y219 Phosphorylation
S221 Phosphorylation
R224 Methylation
R230 Methylation
R232 Methylation
R233 Methylation
Y236 Phosphorylation
Y240 Phosphorylation
Y243 Phosphorylation
Y246 Phosphorylation
Y249 Phosphorylation
Y253 Phosphorylation
S257 Phosphorylation
R259 Methylation
R262 Methylation
Y266 Phosphorylation
C267 S-Nitrosylation
S269 Phosphorylation
S272 Phosphorylation
Y276 Phosphorylation
T286 Phosphorylation
R294 Methylation
T301 Phosphorylation
Y306 Phosphorylation
S310 Phosphorylation
T328 Phosphorylation
S346 Phosphorylation
K349 Ubiquitination
S368 Phosphorylation
Y372 Phosphorylation
Y376 Phosphorylation

研究背景

功能:

This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG).

细胞定位:

Nucleus>Nucleoplasm.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Expressed ubiquitously.

亚基结构:

Part of a ternary complex containing FUBP2, PTBP1, PTBP2 and HNRNPH1. Identified in the spliceosome C complex. Interacts with IGF2BP1. Interacts with CUGBP1; the interaction is RNA-dependent. Interacts with MBNL1; the interaction in RNA-independent.

蛋白家族:

Each quasi-RRM repeat bound poly(RG), while only the N-terminal QRRM bound poly(RC) and poly(RU). None of the repeats bound detectable amounts of poly(RA).

功能:

This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG).

细胞定位:

Nucleus>Nucleoplasm.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Expressed ubiquitously.

亚基结构:

Interacts with TXNL4/DIM1.

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