| 产品: | HMG14 抗体 |
| 货号: | DF8777 |
| 描述: | Rabbit polyclonal antibody to HMG14 |
| 应用: | WB IF/ICC |
| 反应: | Human |
| 预测: | Pig, Bovine, Horse, Dog, Chicken, Xenopus |
| 分子量: | 10 kDa; 11kD(Calculated). |
| 蛋白号: | P05114 |
| RRID: | AB_2841980 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF8777, RRID:AB_2841980.
展开/折叠
FLJ27265; FLJ31471; High mobility group (nonhistone chromosomal) protein 14; High mobility group nucleosome binding 1; High mobility group nucleosome binding domain 1; High mobility group nucleosome binding domain containing protein 1; High mobility group nucleosome-binding domain-containing protein 1; High mobility group protein 14; HMG 14; HMG14; HMGN 1; HMGN1; HMGN1_HUMAN; MGC104230; MGC117425; Non-histone chromosomal protein HMG-14; Nonhistone chromosomal protein HMG 14; Nonhistone chromosomal protein HMG14;
抗原和靶标
- P05114 HMGN1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPKRKVSSAEGAAKEEPKRRSARLSAKPPAKVEAKPKKAAAKDKSSDKKVQTKGKRGAKGKQAEVANQETKEDLPAENGETKTEESPASDEAGEKEAKSD
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P05114 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K3 | Acetylation | Uniprot | |
| K5 | Acetylation | Uniprot | |
| K5 | Methylation | Uniprot | |
| K5 | Ubiquitination | Uniprot | |
| S7 | Phosphorylation | P68400 (CSNK2A1) , O75676 (RPS6KA4) , P17612 (PRKACA) , P51812 (RPS6KA3) , O75582 (RPS6KA5) , P17252 (PRKCA) | Uniprot |
| S8 | Phosphorylation | P68400 (CSNK2A1) | Uniprot |
| K14 | Acetylation | Uniprot | |
| K14 | Ubiquitination | Uniprot | |
| K18 | Acetylation | Uniprot | |
| S21 | Phosphorylation | P51812 (RPS6KA3) , P17612 (PRKACA) , P17252 (PRKCA) | Uniprot |
| S25 | Phosphorylation | P17252 (PRKCA) , P51812 (RPS6KA3) , P17612 (PRKACA) | Uniprot |
| K27 | Acetylation | Uniprot | |
| K27 | Ubiquitination | Uniprot | |
| K31 | Acetylation | Uniprot | |
| K31 | Ubiquitination | Uniprot | |
| K38 | Acetylation | Uniprot | |
| K42 | Acetylation | Uniprot | |
| K48 | Acetylation | Uniprot | |
| K53 | Acetylation | Uniprot | |
| K55 | Acetylation | Uniprot | |
| K59 | Acetylation | Uniprot | |
| K61 | Acetylation | Uniprot | |
| K61 | Ubiquitination | Uniprot | |
| T70 | Phosphorylation | Uniprot | |
| K71 | Ubiquitination | Uniprot | |
| T81 | Phosphorylation | Uniprot | |
| K82 | Acetylation | Uniprot | |
| K82 | Ubiquitination | Uniprot | |
| T83 | Phosphorylation | Uniprot | |
| S86 | Phosphorylation | P68400 (CSNK2A1) | Uniprot |
| S89 | Phosphorylation | P68400 (CSNK2A1) | Uniprot |
| K95 | Ubiquitination | Uniprot | |
| K98 | Ubiquitination | Uniprot | |
| S99 | Phosphorylation | P68400 (CSNK2A1) | Uniprot |
研究背景
Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity).
Phosphorylation on Ser-21 and Ser-25 weakens binding to nucleosomes and increases the rate of H3 phosphorylation (By similarity). Phosphorylation favors cytoplasmic localization.
Nucleus. Cytoplasm.
Note: Cytoplasmic enrichment upon phosphorylation. The RNA edited version localizes to the nucleus.
Belongs to the HMGN family.
研究领域
· Human Diseases > Infectious diseases: Viral > Herpes simplex infection.
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