| 产品: | SFRS6 抗体 |
| 货号: | DF8824 |
| 描述: | Rabbit polyclonal antibody to SFRS6 |
| 应用: | WB |
| 反应: | Human, Mouse, Rat |
| 预测: | Chicken |
| 分子量: | 40 kDa; 40kD(Calculated). |
| 蛋白号: | Q13247 |
| RRID: | AB_2842021 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF8824, RRID:AB_2842021.
展开/折叠
arginine/serine-rich 6; B52; Epididymis secretory protein Li 91; fc17h09; HEL S 91; MGC128807; MGC5045; Pre mRNA splicing factor SRP55; Pre-mRNA-splicing factor SRP55; Serine/arginine-rich splicing factor 6; SFRS6; Splicing factor; Splicing factor arginine/serine rich 55 kDa; Splicing factor arginine/serine rich 6; SR splicing factor 6; SRP55; SRSF6; SRSF6_HUMAN; wu:faa54g02; wu:fc17h09; zgc:103497;
抗原和靶标
- Q13247 SRSF6_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPRVYIGRLSYNVREKDIQRFFSGYGRLLEVDLKNGYGFVEFEDSRDADDAVYELNGKELCGERVIVEHARGPRRDRDGYSYGSRSGGGGYSSRRTSGRDKYGPPVRTEYRLIVENLSSRCSWQDLKDFMRQAGEVTYADAHKERTNEGVIEFRSYSDMKRALDKLDGTEINGRNIRLIEDKPRTSHRRSYSGSRSRSRSRRRSRSRSRRSSRSRSRSISKSRSRSRSRSKGRSRSRSKGRKSRSKSKSKPKSDRGSHSHSRSRSKDEYEKSRSRSRSRSPKENGKGDIKSKSRSRSQSRSNSPLPVPPSKARSVSPPPKRATSRSRSRSRSKSRSRSRSSSRD
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q13247 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S23 | Phosphorylation | Uniprot | |
| S45 | Phosphorylation | Uniprot | |
| Y53 | Phosphorylation | Uniprot | |
| K58 | Ubiquitination | Uniprot | |
| R71 | Methylation | Uniprot | |
| Y80 | Phosphorylation | Uniprot | |
| S81 | Phosphorylation | Uniprot | |
| Y82 | Phosphorylation | Uniprot | |
| S84 | Phosphorylation | Uniprot | |
| R85 | Methylation | Uniprot | |
| S86 | Phosphorylation | Uniprot | |
| Y91 | Phosphorylation | Uniprot | |
| S97 | Phosphorylation | Uniprot | |
| K101 | Acetylation | Uniprot | |
| K101 | Ubiquitination | Uniprot | |
| Y102 | Phosphorylation | Uniprot | |
| S118 | Phosphorylation | Uniprot | |
| S119 | Phosphorylation | Uniprot | |
| S122 | Phosphorylation | Uniprot | |
| K127 | Ubiquitination | Uniprot | |
| T137 | Phosphorylation | Uniprot | |
| Y138 | Phosphorylation | Uniprot | |
| K143 | Ubiquitination | Uniprot | |
| T146 | Phosphorylation | Uniprot | |
| S157 | Phosphorylation | Uniprot | |
| K165 | Acetylation | Uniprot | |
| K165 | Ubiquitination | Uniprot | |
| T169 | Phosphorylation | Uniprot | |
| K182 | Acetylation | Uniprot | |
| K182 | Ubiquitination | Uniprot | |
| S190 | Phosphorylation | Uniprot | |
| Y191 | Phosphorylation | Uniprot | |
| S192 | Phosphorylation | Uniprot | |
| S194 | Phosphorylation | Uniprot | |
| S196 | Phosphorylation | Uniprot | |
| S253 | Phosphorylation | Uniprot | |
| S257 | Phosphorylation | Uniprot | |
| S259 | Phosphorylation | Uniprot | |
| S261 | Phosphorylation | Uniprot | |
| S263 | Phosphorylation | Uniprot | |
| S265 | Phosphorylation | Uniprot | |
| Y269 | Phosphorylation | Uniprot | |
| S272 | Phosphorylation | Uniprot | |
| S274 | Phosphorylation | Uniprot | |
| K290 | Acetylation | Uniprot | |
| S291 | Phosphorylation | Uniprot | |
| S293 | Phosphorylation | Uniprot | |
| S295 | Phosphorylation | Uniprot | |
| S297 | Phosphorylation | Uniprot | |
| S299 | Phosphorylation | Uniprot | |
| S301 | Phosphorylation | Uniprot | |
| S303 | Phosphorylation | Uniprot | |
| S310 | Phosphorylation | Uniprot | |
| S314 | Phosphorylation | Uniprot | |
| S316 | Phosphorylation | Uniprot | |
| S326 | Phosphorylation | Uniprot |
研究背景
Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing.
Extensively phosphorylated on serine residues in the RS domain. Phosphorylated by DYRK1A, probably in the RS domain. Phosphorylation by DYRK1A modulates alternative splice site selection and inhibits the expression of MAPT/Tau exon 10.
Nucleus. Nucleus speckle.
Binds SREK1/SFRS12. Interacts with DYRK1A.
Belongs to the splicing factor SR family.
研究领域
· Genetic Information Processing > Transcription > Spliceosome.
· Human Diseases > Infectious diseases: Viral > Herpes simplex infection.
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