| 产品: | CCRN4L 抗体 |
| 货号: | DF8828 |
| 描述: | Rabbit polyclonal antibody to CCRN4L |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse, Rat, Monkey |
| 预测: | Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 48 kDa; 48kD(Calculated). |
| 蛋白号: | Q9UK39 |
| RRID: | AB_2842025 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF8828, RRID:AB_2842025.
展开/折叠
CCR4 carbon catabolite repression 4 like (S. cerevisiae); CCR4 protein homolog; CCRN4L; NOC;
抗原和靶标
Adipose tissue. Expression is higher in subcutaneous adipose tissue as compared to visceral adipose tissue.
- Q9UK39 NOCT_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MFHSPRRLCSALLQRDAPGLRRLPAPGLRRPLSPPAAVPRPASPRLLAAASAASGAARSCSRTVCSMGTGTSRLYSALAKTLNSSAASQHPEYLVSPDPEHLEPIDPKELLEECRAVLHTRPPRFQRDFVDLRTDCPSTHPPIRVMQWNILAQALGEGKDNFVQCPVEALKWEERKCLILEEILAYQPDILCLQEVDHYFDTFQPLLSRLGYQGTFFPKPWSPCLDVEHNNGPDGCALFFLQNRFKLVNSANIRLTAMTLKTNQVAIAQTLECKESGRQFCIAVTHLKARTGWERFRSAQGCDLLQNLQNITQGAKIPLIVCGDFNAEPTEEVYKHFASSSLNLNSAYKLLSADGQSEPPYTTWKIRTSGECRHTLDYIWYSKHALNVRSALDLLTEEQIGPNRLPSFNYPSDHLSLVCDFSFTEESDGLS
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9UK39 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S33 | Phosphorylation | Uniprot | |
| S43 | Phosphorylation | Uniprot | |
| S66 | Phosphorylation | Uniprot | |
| T69 | Phosphorylation | Uniprot | |
| T71 | Phosphorylation | Uniprot | |
| S72 | Phosphorylation | Uniprot | |
| S96 | Phosphorylation | Uniprot | |
| R121 | Methylation | Uniprot | |
| R124 | Methylation | Uniprot | |
| K171 | Ubiquitination | Uniprot | |
| K274 | Ubiquitination | Uniprot | |
| T285 | Phosphorylation | Uniprot | |
| K365 | Ubiquitination | Uniprot |
研究背景
Phosphatase which catalyzes the conversion of NADP(+) to NAD(+) and of NADPH to NADH. Shows a small preference for NADPH over NADP(+). Represses translation and promotes degradation of target mRNA molecules. Plays an important role in post-transcriptional regulation of metabolic genes under circadian control (By similarity). Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis (By similarity). Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance (By similarity). Promotes adipogenesis by facilitating PPARG nuclear translocation which activates its transcriptional activity (By similarity). Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone (By similarity). Critical for proper development of early embryos (By similarity).
Cytoplasm. Nucleus. Cytoplasm>Perinuclear region. Mitochondrion.
Adipose tissue. Expression is higher in subcutaneous adipose tissue as compared to visceral adipose tissue.
Interacts with PPARG.
Belongs to the CCR4/nocturin family.
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