| 产品: | MBIP1 抗体 |
| 货号: | DF8877 |
| 描述: | Rabbit polyclonal antibody to MBIP1 |
| 应用: | WB IHC |
| 反应: | Human |
| 预测: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Xenopus |
| 分子量: | 39 kDa; 39kD(Calculated). |
| 蛋白号: | Q9NS73 |
| RRID: | AB_2842073 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF8877, RRID:AB_2842073.
展开/折叠
MAP3K12 binding inhibitory protein 1; MAP3K12-binding inhibitory protein 1; MAPK upstream kinase binding inhibitory protein; MAPK upstream kinase-binding inhibitory protein; Mbip; MBIP1_HUMAN; MUK binding inhibitory protein; MUK-binding inhibitory protein; OTTHUMP00000178844;
抗原和靶标
- Q9NS73 MBIP1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAAATELNRPSSGDRNLERRCRPNLSREVLYEIFRSLHTLVGQLDLRDDVVKITIDWNKLQSLSAFQPALLFSALEQHILYLQPFLAKLQSPIKEENTTAVEEIGRTEMGNKNEVNDKFSIGDLQEEEKHKESDLRDVKKTQIHFDPEVVQIKAGKAEIDRRISAFIERKQAEINENNVREFCNVIDCNQENSCARTDAIFTPYPGFKSHVKVSRVVNTYGPQTRPEGIPGSGHKPNSMLRDCGNQAVEERLQNIEAHLRLQTGGPVPRDIYQRIKKLEDKILELEGISPEYFQSVSFSGKRRKVQPPQQNYSLAELDEKISALKQALLRKSREAESMATHHLP
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9NS73 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S11 | Phosphorylation | Uniprot | |
| S12 | Phosphorylation | Uniprot | |
| S91 | Phosphorylation | Uniprot | |
| K94 | Sumoylation | Uniprot | |
| K94 | Ubiquitination | Uniprot | |
| T107 | Phosphorylation | Uniprot | |
| K118 | Ubiquitination | Uniprot | |
| K129 | Ubiquitination | Uniprot | |
| K140 | Ubiquitination | Uniprot | |
| K153 | Ubiquitination | Uniprot | |
| S164 | Phosphorylation | Uniprot | |
| K170 | Ubiquitination | Uniprot | |
| K208 | Ubiquitination | Uniprot | |
| S232 | Phosphorylation | Uniprot | |
| K235 | Ubiquitination | Uniprot | |
| K301 | Acetylation | Uniprot | |
| K304 | Ubiquitination | Uniprot | |
| K320 | Ubiquitination | Uniprot | |
| K325 | Ubiquitination | Uniprot |
研究背景
Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.
Nucleus. Cytoplasm.
Note: Shows a cytoplasmic localization when coexpressed with MAP3K12.
Ubiquitous. High expression seen in the heart and lung.
Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1. In the complex, it probably interacts directly with KAT2A, KAT14 and WDR5.
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