| 产品: | ARRS 抗体 |
| 货号: | DF8919 |
| 描述: | Rabbit polyclonal antibody to ARRS |
| 应用: | WB IHC |
| 反应: | Human, Rat |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Xenopus |
| 分子量: | 45 kDa; 45kD(Calculated). |
| 蛋白号: | P10523 |
| RRID: | AB_2842115 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF8919, RRID:AB_2842115.
展开/折叠
48 kDa protein; Arrestin 1; Arrestin; ARRS_HUMAN; Retinal S antigen (48 KDa protein); Retinal S-antigen; Rod photoreceptor arrestin; RP47; S antigen; S antigen retina and pineal gland (arrestin); S arrestin; S-AG; S-arrestin; SAG;
抗原和靶标
Detected in retina, in the proximal portion of the outer segment of rod photoreceptor cells (at protein level).
- P10523 ARRS_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAASGKTSKSEPNHVIFKKISRDKSVTIYLGNRDYIDHVSQVQPVDGVVLVDPDLVKGKKVYVTLTCAFRYGQEDIDVIGLTFRRDLYFSRVQVYPPVGAASTPTKLQESLLKKLGSNTYPFLLTFPDYLPCSVMLQPAPQDSGKSCGVDFEVKAFATDSTDAEEDKIPKKSSVRLLIRKVQHAPLEMGPQPRAEAAWQFFMSDKPLHLAVSLNKEIYFHGEPIPVTVTVTNNTEKTVKKIKAFVEQVANVVLYSSDYYVKPVAMEEAQEKVPPNSTLTKTLTLLPLLANNRERRGIALDGKIKHEDTNLASSTIIKEGIDRTVLGILVSYQIKVKLTVSGFLGELTSSEVATEVPFRLMHPQPEDPAKESYQDANLVFEEFARHNLKDAGEAEEGKRDKNDVDE
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P10523 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K9 | Acetylation | Uniprot | |
| Y29 | Phosphorylation | Uniprot | |
| Y62 | Phosphorylation | Uniprot | |
| T64 | Phosphorylation | Uniprot | |
| T66 | Phosphorylation | Uniprot | |
| Y120 | Phosphorylation | Uniprot | |
| Y129 | Phosphorylation | Uniprot | |
| S143 | Phosphorylation | Uniprot | |
| Y254 | Phosphorylation | Uniprot | |
| Y258 | Phosphorylation | Uniprot | |
| S348 | Phosphorylation | Uniprot | |
| S349 | Phosphorylation | Uniprot | |
| T353 | Phosphorylation | Uniprot |
研究背景
Binds to photoactivated, phosphorylated RHO and terminates RHO signaling via G-proteins by competing with G-proteins for the same binding site on RHO (By similarity). May play a role in preventing light-dependent degeneration of retinal photoreceptor cells.
Cell projection>Cilium>Photoreceptor outer segment. Membrane>Peripheral membrane protein.
Note: Highly expressed in photoreceptor outer segments in light-exposed retina. Evenly distributed throughout rod photoreceptor cells in dark-adapted retina (By similarity). Predominantly dectected at the proximal region of photoreceptor outer segments, near disk membranes (PubMed:3720866).
Detected in retina, in the proximal portion of the outer segment of rod photoreceptor cells (at protein level).
Monomer. Homodimer. Homotetramer. Interacts with RHO (via the phosphorylated C-terminus).
The C-terminus interferes with binding to non-phosphorylated RHO. Interaction with phosphorylated RHO triggers displacement of the C-terminus and leads to a conformation change that mediates high-affinity RHO binding.
Belongs to the arrestin family.
研究领域
· Organismal Systems > Sensory system > Phototransduction.
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