GTSE1 Antibody - #DF8953

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产品: GTSE1 抗体
货号: DF8953
描述: Rabbit polyclonal antibody to GTSE1
应用: WB IHC
文献验证: WB
反应: Human, Mouse
分子量: 77 kDa; 77kD(Calculated).
蛋白号: Q9NYZ3
RRID: AB_2842149

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   规格 价格 库存
 50ul RMB¥ 1500 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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说明书
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实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
IHC 1:50-1:200, WB 1:1000-3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse
克隆:
Polyclonal
特异性:
GTSE1 Antibody detects endogenous levels of total GTSE1.
RRID:
AB_2842149
引用格式: Affinity Biosciences Cat# DF8953, RRID:AB_2842149.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

B99; B99 homolog; G 2 and S phase expressed 1; G two S phase expressed protein 1; GTSE 1;

抗原和靶标

免疫原:
Uniprot:

Q9NYZ3(GTSE1_HUMAN) >>Visit HPA database.

基因/基因ID:
GTSE1(51512)
序列:
MDDPKKEDILLLADEKFDFDLSLSSSSANEDDEVFFGPFGHKERCIAASLELNNPVPEQPPLPTSESPFAWSPLAGEKFVEVYKEAHLLALHIESSSRNQAAQAAKPEDPRSQGVERFIQESKLKINLFEKEKEMKKSPTSLKRETYYLSDSPLLGPPVGEPRLLASSPALPSSGAQARLTRAPGPPHSAHALPRESCTAHAASQAATQRKPGTKLLLPRAASVRGRSIPGAAEKPKKEIPASPSRTKIPAEKESHRDVLPDKPAPGAVNVPAAGSHLGQGKRAIPVPNKLGLKKTLLKAPGSTSNLARKSSSGPVWSGASSACTSPAVGKAKSSEFASIPANSSRPLSNISKSGRMGPAMLRPALPAGPVGASSWQAKRVDVSELAAEQLTAPPSASPTQPQTPEGGGQWLNSSCAWSESSQLNKTRSIRRRDSCLNSKTKVMPTPTNQFKIPKFSIGDSPDSSTPKLSRAQRPQSCTSVGRVTVHSTPVRRSSGPAPQSLLSAWRVSALPTPASRRCSGLPPMTPKTMPRAVGSPLCVPARRRSSEPRKNSAMRTEPTRESNRKTDSRLVDVSPDRGSPPSRVPQALNFSPEESDSTFSKSTATEVAREEAKPGGDAAPSEALLVDIKLEPLAVTPDAASQPLIDLPLIDFCDTPEAHVAVGSESRPLIDLMTNTPDMNKNVAKPSPVVGQLIDLSSPLIQLSPEADKENVDSPLLKF

翻译修饰 - Q9NYZ3 作为底物

Site PTM Type Enzyme
K6 Sumoylation
K6 Ubiquitination
S67 Phosphorylation
S72 Phosphorylation
Y83 Phosphorylation
S95 Phosphorylation
K106 Ubiquitination
S112 Phosphorylation
K123 Sumoylation
K123 Ubiquitination
K125 Ubiquitination
K131 Ubiquitination
S138 Phosphorylation
T140 Phosphorylation
S141 Phosphorylation
K143 Sumoylation
T146 Phosphorylation
Y147 Phosphorylation
Y148 Phosphorylation
S150 Phosphorylation
S152 Phosphorylation
S167 Phosphorylation
S168 Phosphorylation
S173 Phosphorylation
S174 Phosphorylation
R182 Methylation
S189 Phosphorylation
K215 Methylation
S223 Phosphorylation P53350 (PLK1)
S228 Phosphorylation
S243 Phosphorylation
S245 Phosphorylation
S276 Phosphorylation
K299 Ubiquitination
S303 Phosphorylation
T304 Phosphorylation
K310 Methylation
S311 Phosphorylation
S312 Phosphorylation
S313 Phosphorylation
S322 Phosphorylation
S326 Phosphorylation
K331 Methylation
K333 Ubiquitination
S334 Phosphorylation
S339 Phosphorylation
S345 Phosphorylation
S349 Phosphorylation
K353 Ubiquitination
S354 Phosphorylation
K379 Ubiquitination
S429 Phosphorylation
S435 Phosphorylation P53350 (PLK1)
S439 Phosphorylation
T446 Phosphorylation
K452 Ubiquitination
K455 Ubiquitination
S457 Phosphorylation
S461 Phosphorylation P28482 (MAPK1)
S464 Phosphorylation
T466 Phosphorylation
S477 Phosphorylation
T479 Phosphorylation
S480 Phosphorylation
T485 Phosphorylation
S488 Phosphorylation
T489 Phosphorylation
R492 Methylation
S494 Phosphorylation
S495 Phosphorylation
S501 Phosphorylation
S504 Phosphorylation
S509 Phosphorylation
T513 Phosphorylation
S516 Phosphorylation
S520 Phosphorylation
T526 Phosphorylation
T529 Phosphorylation
S536 Phosphorylation
S575 Phosphorylation
S580 Phosphorylation
S583 Phosphorylation
S592 Phosphorylation
S596 Phosphorylation
T656 Phosphorylation
T675 Phosphorylation
T677 Phosphorylation
S688 Phosphorylation
S698 Phosphorylation
S699 Phosphorylation
S705 Phosphorylation
S715 Phosphorylation

研究背景

功能:

May be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis. Overexpression delays G2/M phase progression.

翻译修饰:

Phosphorylated in mitosis.

细胞定位:

Cytoplasm>Cytoskeleton.
Note: Associated with microtubules.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location

研究领域

· Cellular Processes > Cell growth and death > p53 signaling pathway.   (View pathway)

文献引用

1). miR-181a-5p restrains non-small cell lung cancer cell invasion and migration by regulating the GTSE1/p53/NF-κB axis. CELLS TISSUES ORGANS, 2022 (PubMed: 35700709) [IF=2.9]

Application: WB    Species: Human    Sample: NSCLC cells

Figure 1 miR-181a-5p was down-regulated and GTSE1 was up-regulated in NSCLC cells. A: expression of miR-181a5p detected by RT-qPCR; B: expression of GTSE1 detected by RT-qPCR; C: protein expression of GTSE1 detected by Western blot. Cell experiment was replicated 3 times. Data were described as mean ± standard deviation. Data comparisons between two groups were analyzed using the t test. The post hoc test was conducted using Tukey’s multiple comparisons test.

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