| 产品: | IL17C 抗体 |
| 货号: | DF8980 |
| 描述: | Rabbit polyclonal antibody to IL17C |
| 应用: | WB IHC |
| 反应: | Human, Mouse |
| 分子量: | 22 kDa; 22kD(Calculated). |
| 蛋白号: | Q9P0M4 |
| RRID: | AB_2842176 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF8980, RRID:AB_2842176.
展开/折叠
CX2; Cytokine CX2; IL 17C; il17 C;IL 21; IL-17C; IL17C; IL17C_HUMAN; Interleukin 17C; Interleukin-17C; MGC126884; MGC138401;
抗原和靶标
- Q9P0M4 IL17C_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTLLPGLLFLTWLHTCLAHHDPSLRGHPHSHGTPHCYSAEELPLGQAPPHLLARGAKWGQALPVALVSSLEAASHRGRHERPSATTQCPVLRPEEVLEADTHQRSISPWRYRVDTDEDRYPQKLAFAECLCRGCIDARTGRETAALNSVRLLQSLLVLRRRPCSRDGSGLPTPGAFAFHTEFIHVPVGCTCVLPRSV
研究背景
Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases.
Secreted.
Binds to a heterodimer formed by IL17RA and IL17RE.
Belongs to the IL-17 family.
研究领域
· Environmental Information Processing > Signaling molecules and interaction > Cytokine-cytokine receptor interaction. (View pathway)
· Organismal Systems > Immune system > IL-17 signaling pathway. (View pathway)
限制条款
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