| 产品: | INGR2 抗体 |
| 货号: | DF8988 |
| 描述: | Rabbit polyclonal antibody to INGR2 |
| 应用: | WB |
| 反应: | Human |
| 预测: | Bovine, Sheep, Rabbit, Dog |
| 分子量: | 38 kDa; 38kD(Calculated). |
| 蛋白号: | P38484 |
| RRID: | AB_2842184 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF8988, RRID:AB_2842184.
展开/折叠
AF 1; AF-1; AF1; IFGR 2; IFGR2; IFN-gamma receptor 2; IFN-gamma-R2; IFNGR 2; IFNGR2; IFNGT 1; IFNGT1; IMD28; INGR2_HUMAN; Interferon gamma receptor 2 (interferon gamma transducer 1); Interferon gamma receptor 2; Interferon gamma receptor accessory factor 1; Interferon gamma receptor beta chain; Interferon gamma receptor chain 2; Interferon gamma transducer 1;
抗原和靶标
- P38484 INGR2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MRPTLLWSLLLLLGVFAAAAAAPPDPLSQLPAPQHPKIRLYNAEQVLSWEPVALSNSTRPVVYQVQFKYTDSKWFTADIMSIGVNCTQITATECDFTAASPSAGFPMDFNVTLRLRAELGALHSAWVTMPWFQHYRNVTVGPPENIEVTPGEGSLIIRFSSPFDIADTSTAFFCYYVHYWEKGGIQQVKGPFRSNSISLDNLKPSRVYCLQVQAQLLWNKSNIFRVGHLSNISCYETMADASTELQQVILISVGTFSLLSVLAGACFFLVLKYRGLIKYWFHTPPSIPLQIEEYLKDPTQPILEALDKDSSPKDDVWDSVSIISFPEKEQEDVLQTL
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P38484 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| N56 | N-Glycosylation | Uniprot | |
| N85 | N-Glycosylation | Uniprot | |
| N110 | N-Glycosylation | Uniprot | |
| N137 | N-Glycosylation | Uniprot | |
| S198 | Phosphorylation | Uniprot | |
| N219 | N-Glycosylation | Uniprot | |
| N231 | N-Glycosylation | Uniprot | |
| K308 | Ubiquitination | Uniprot | |
| S324 | Phosphorylation | Uniprot | |
| T336 | Phosphorylation | Uniprot |
研究背景
Associates with IFNGR1 to form a receptor for the cytokine interferon gamma (IFNG). Ligand binding stimulates activation of the JAK/STAT signaling pathway. Required for signal transduction in contrast to other receptor subunit responsible for ligand binding.
Cell membrane>Single-pass type I membrane protein. Cytoplasmic vesicle membrane>Single-pass type I membrane protein. Golgi apparatus membrane>Single-pass type I membrane protein. Endoplasmic reticulum membrane>Single-pass type I membrane protein. Cytoplasm.
Note: Has low cell surface expression and high cytoplasmic expression in T cells. The bias towards cytoplasmic expression may be due to ligand-independent receptor internalization and recycling.
Expressed in T-cells (at protein level).
Heterodimer with IFNGR1, to form the IFNG receptor complex. Interacts (via intracellular domain) with JAK2.
Belongs to the type II cytokine receptor family.
研究领域
· Cellular Processes > Cell growth and death > Necroptosis. (View pathway)
· Environmental Information Processing > Signaling molecules and interaction > Cytokine-cytokine receptor interaction. (View pathway)
· Environmental Information Processing > Signal transduction > HIF-1 signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Jak-STAT signaling pathway. (View pathway)
· Human Diseases > Infectious diseases: Bacterial > Salmonella infection.
· Human Diseases > Infectious diseases: Parasitic > Leishmaniasis.
· Human Diseases > Infectious diseases: Parasitic > Chagas disease (American trypanosomiasis).
· Human Diseases > Infectious diseases: Parasitic > Toxoplasmosis.
· Human Diseases > Infectious diseases: Bacterial > Tuberculosis.
· Human Diseases > Infectious diseases: Viral > Measles.
· Human Diseases > Infectious diseases: Viral > Influenza A.
· Human Diseases > Infectious diseases: Viral > Herpes simplex infection.
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
· Human Diseases > Immune diseases > Inflammatory bowel disease (IBD).
· Organismal Systems > Development > Osteoclast differentiation. (View pathway)
· Organismal Systems > Immune system > Natural killer cell mediated cytotoxicity. (View pathway)
· Organismal Systems > Immune system > Th1 and Th2 cell differentiation. (View pathway)
· Organismal Systems > Immune system > Th17 cell differentiation. (View pathway)
限制条款
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