| 产品: | IFI27 抗体 |
| 货号: | DF8989 |
| 描述: | Rabbit polyclonal antibody to IFI27 |
| 应用: | WB IHC |
| 反应: | Human |
| 分子量: | 11 kDa; 12kD(Calculated). |
| 蛋白号: | P40305 |
| RRID: | AB_2842185 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF8989, RRID:AB_2842185.
展开/折叠
2310061N23Rik; FAM 14D; FAM14D; IFI 27; IFI27; IFI27_HUMAN; Interferon alpha induced 11.5 kDa protein; Interferon alpha inducible protein 27; Interferon alpha-induced 11.5 kDa protein; Interferon alpha-inducible protein 27; interferon alpha-inducible protein 27, mitochondrial; Interferon inducible protein 27; interferon-stimulated gene 12; Interferon-stimulated gene 12a protein; ISG 12; ISG12; ISG12(a); ISG12(a) protein; ISG12A; mitochondrial; p27;
抗原和靶标
- P40305 IFI27_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEASALTSSAVTSVAKVVRVASGSAVVLPLARIATVVIGGVVAMAAVPMVLSAMGFTAAGIASSSIAAKMMSAAAIANGGGVASGSLVATLQSLGATGLSGLTKFILGSIGSAIAAVIARFY
翻译修饰 - P40305 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T7 | Phosphorylation | Uniprot | |
| S8 | Phosphorylation | Uniprot | |
| S24 | Phosphorylation | Uniprot |
研究背景
Probable adapter protein involved in different biological processes. Part of the signaling pathways that lead to apoptosis. Involved in type-I interferon-induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9. Also functions in TNFSF10-induced apoptosis. May also have a function in the nucleus, where it may be involved in the interferon-induced negative regulation of the transcriptional activity of NR4A1, NR4A2 and NR4A3 through the enhancement of XPO1-mediated nuclear export of these nuclear receptors. May thereby play a role in the vascular response to injury (By similarity). In the innate immune response, has an antiviral activity towards hepatitis C virus/HCV. May prevent the replication of the virus by recruiting both the hepatitis C virus non-structural protein 5A/NS5A and the ubiquitination machinery via SKP2, promoting the ubiquitin-mediated proteasomal degradation of NS5A.
Mitochondrion membrane>Multi-pass membrane protein. Nucleus inner membrane>Multi-pass membrane protein. Endoplasmic reticulum membrane>Multi-pass membrane protein.
Note: Exclusive localizations in either the nucleus or the mitochondrion have been reported.
Homodimer. Interacts with hepatitis C virus/HCV non-structural protein NS5A; promotes the ubiquitin-mediated proteasomal degradation of NS5A. Interacts with SKP2; promotes the ubiquitin-mediated proteasomal degradation of NS5A. Interacts with NR4A1. May interact with BCL2.
Belongs to the IFI6/IFI27 family.
限制条款
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