产品: KRT83 抗体
货号: DF9013
描述: Rabbit polyclonal antibody to KRT83
应用: WB
反应: Human
分子量: 55 kDa; 54kD,55kD,56kD(Calculated).
蛋白号: P78385 | Q14533 | P78386 | O43790
RRID: AB_2842209

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 100ul RMB¥ 2300 现货
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产品描述

来源:
Rabbit
应用:
WB 1:1000-3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human
克隆:
Polyclonal
特异性:
KRT83 Antibody detects endogenous levels of total KRT83.
RRID:
AB_2842209
引用格式: Affinity Biosciences Cat# DF9013, RRID:AB_2842209.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Hair keratin K2.10; Hard keratin, type II, 3; HB 3; HB3; hHb3; K2.10; K83; Keratin 83; Keratin; Keratin, hair, basic, 3; Keratin-83; Krt83; KRT83_HUMAN; KRTHB3; type II cuticular Hb3; Type II hair keratin Hb3; Type-II keratin Kb23; 1; basic; ghHb 1; ghHb1; ghHkb 1; ghHKb1; hair; Hair keratin K2.9; Hard keratin type II 1; HB 1; HB1; hHAKB2 1; K2.9; K81; Keratin 81; Keratin; Keratin hair basic 1; Keratin type II cuticular Hb1; Keratin-81; Keratin81; KRT 81; KRT81; KRT81_HUMAN; KRTHB 1; KRTHB1; Metastatic lymph node 137 gene protein; MLN 137; MLN137; type II cuticular Hb1; Type II hair keratin Hb1; Type-II keratin Kb21; ECTD4; Hair keratin K2.12; Hard keratin type II 5; Hb 5; HB5; hHb5; K12.12; K85; Keratin 85; keratin hair basic 5; Keratin type II cuticular Hb5; keratin, hard, type II; KRTHB5; type II cuticular Hb5; Type II hair keratin Hb5; Type II keratin Kb25; Hair keratin K2.11; Hb6; K86; Keratin; Keratin-86; KRT86; KRT86_HUMAN; KRTHB6; MNX; type II cuticular Hb6; Type II hair keratin Hb6; Type-II keratin Kb26;

抗原和靶标

免疫原:
Uniprot:
基因/基因ID:
表达:
P78385 KRT83_HUMAN:

Synthesis begins in the cortex 10-15 cell layers above the apex of the dermal papilla and ends abruptly in the middle of the cortex.

Q14533 KRT81_HUMAN:

Abundantly expressed in the differentiating cortex of growing (anagen) hair. Expression is restricted to the keratinocytes of the hair cortex and is absent from inner root sheath and medulla. Expressed in malignant lymph node tissue in breast carcinoma tissue.

P78386 KRT85_HUMAN:

Synthesis occurs immediately above a small population of matrix cells at the base of the hair bulb and the trichocytes lining the dermal papilla and extends upward through the matrix and ends in the lower part of the cortex of the hair shaft.

O43790 KRT86_HUMAN:

Synthesis begins slightly higher in the hair shaft than HB1 and HB3 and continues much farther up, ending in the keratogeneous zone.

序列:
MTCGFNSIGCGFRPGNFSCVSACGPRPSRCCITAAPYRGISCYRGLTGGFGSHSVCGGFRAGSCGRSFGYRSGGVCGPSPPCITTVSVNESLLTPLNLEIDPNAQCVKQEEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPLFAGYIETLRREAECVEADSGRLASELNHVQEVLEGYKKKYEEEVALRATAENEFVALKKDVDCAYLRKSDLEANVEALIQEIDFLRRLYEEEIRILQSHISDTSVVVKLDNSRDLNMDCIVAEIKAQYDDIATRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEVENAKCQNSKLEAAVAQSEQQGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVMNSKLGLDIEIATYRRLLEGEEQRLCEGVEAVNVCVSSSRGGVVCGDLCVSGSRPVTGSVCSAPCNGNLVVSTGLCKPCGQLNTTCGGGSCGQGRH

MTCGSGFGGRAFSCISACGPRPGRCCITAAPYRGISCYRGLTGGFGSHSVCGGFRAGSCGRSFGYRSGGVCGPSPPCITTVSVNESLLTPLNLEIDPNAQCVKQEEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPLFEGYIETLRREAECVEADSGRLASELNHVQEVLEGYKKKYEEEVSLRATAENEFVALKKDVDCAYLRKSDLEANVEALIQEIDFLRRLYEEEILILQSHISDTSVVVKLDNSRDLNMDCIIAEIKAQYDDIVTRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEVENAKCQNSKLEAAVAQSEQQGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVMNSKLGLDIEIATYRRLLEGEEQRLCEGIGAVNVCVSSSRGGVVCGDLCVSGSRPVTGSVCSAPCNGNVAVSTGLCAPCGQLNTTCGGGSCGVGSCGISSLGVGSCGSSCRKC

MSCRSYRISSGCGVTRNFSSCSAVAPKTGNRCCISAAPYRGVSCYRGLTGFGSRSLCNLGSCGPRIAVGGFRAGSCGRSFGYRSGGVCGPSPPCITTVSVNESLLTPLNLEIDPNAQCVKQEEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKWQFYQNQRCCESNLEPLFSGYIETLRREAECVEADSGRLASELNHVQEVLEGYKKKYEEEVALRATAENEFVVLKKDVDCAYLRKSDLEANVEALVEESSFLRRLYEEEIRVLQAHISDTSVIVKMDNSRDLNMDCIIAEIKAQYDDVASRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEIENAKCQRAKLEAAVAEAEQQGEAALSDARCKLAELEGALQKAKQDMACLLKEYQEVMNSKLGLDIEIATYRRLLEGEEHRLCEGVGSVNVCVSSSRGGVSCGGLSYSTTPGRQITSGPSAIGGSITVVAPDSCAPCQPRSSSFSCGSSRSVRFA

MTCGSYCGGRAFSCISACGPRPGRCCITAAPYRGISCYRGLTGGFGSHSVCGGFRAGSCGRSFGYRSGGVCGPSPPCITTVSVNESLLTPLNLEIDPNAQCVKQEEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPLFEGYIETLRREAECVEADSGRLASELNHVQEVLEGYKKKYEEEVSLRATAENEFVALKKDVDCAYLRKSDLEANVEALIQEIDFLRRLYEEEIRVLQSHISDTSVVVKLDNSRDLNMDCIIAEIKAQYDDIVTRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEVENAKCQNSKLEAAVAQSEQQGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVMNSKLGLDIEIATYRRLLEGEEQRLCEGVGSVNVCVSSSRGGVVCGDLCASTTAPVVSTRVSSVPSNSNVVVGTTNACAPSARVGVCGGSCKRC

翻译修饰 - P78385/Q14533/P78386/O43790 作为底物

Site PTM Type Enzyme
S2 Phosphorylation
K149 Ubiquitination
K229 Sumoylation
K229 Ubiquitination
K230 Ubiquitination
Y260 Phosphorylation
Y314 Phosphorylation
K317 Ubiquitination
K322 Ubiquitination
T324 Phosphorylation
T331 Phosphorylation
T335 Phosphorylation
K336 Ubiquitination
K384 Ubiquitination
K394 Ubiquitination
K396 Ubiquitination
S412 Phosphorylation
S493 Phosphorylation
S494 Phosphorylation
Site PTM Type Enzyme
S47 Phosphorylation
S49 Phosphorylation
K132 Ubiquitination
K193 Methylation
T203 Phosphorylation
K222 Methylation
Y243 Phosphorylation
Y282 Phosphorylation
Y297 Phosphorylation
K300 Ubiquitination
K305 Ubiquitination
T307 Phosphorylation
T314 Phosphorylation
T318 Phosphorylation
K319 Ubiquitination
K340 Ubiquitination
K345 Ubiquitination
K367 Ubiquitination
K377 Methylation
K377 Ubiquitination
K379 Ubiquitination
S395 Phosphorylation
S455 Phosphorylation
S460 Phosphorylation
T466 Phosphorylation
S482 Phosphorylation
Site PTM Type Enzyme
S52 Phosphorylation
S54 Phosphorylation
K137 Ubiquitination
Y248 Phosphorylation
S257 Phosphorylation
S263 Phosphorylation
Y302 Phosphorylation
T312 Phosphorylation
T319 Phosphorylation
T323 Phosphorylation
K372 Ubiquitination
S400 Phosphorylation
Site PTM Type Enzyme
S47 Phosphorylation
S49 Phosphorylation
K132 Ubiquitination
T203 Phosphorylation
S252 Phosphorylation
S258 Phosphorylation
Y282 Phosphorylation
Y297 Phosphorylation
K300 Ubiquitination
K305 Ubiquitination
T307 Phosphorylation
T314 Phosphorylation
T318 Phosphorylation
K319 Ubiquitination
K340 Ubiquitination
K345 Ubiquitination
K367 Ubiquitination
K377 Ubiquitination
K379 Ubiquitination
S395 Phosphorylation

研究背景

组织特异性:

Synthesis begins in the cortex 10-15 cell layers above the apex of the dermal papilla and ends abruptly in the middle of the cortex.

亚基结构:

Heterotetramer of two type I and two type II keratins.

蛋白家族:

Belongs to the intermediate filament family.

组织特异性:

Abundantly expressed in the differentiating cortex of growing (anagen) hair. Expression is restricted to the keratinocytes of the hair cortex and is absent from inner root sheath and medulla. Expressed in malignant lymph node tissue in breast carcinoma tissue.

亚基结构:

Heterotetramer of two type I and two type II keratins.

蛋白家族:

Belongs to the intermediate filament family.

组织特异性:

Synthesis occurs immediately above a small population of matrix cells at the base of the hair bulb and the trichocytes lining the dermal papilla and extends upward through the matrix and ends in the lower part of the cortex of the hair shaft.

亚基结构:

Heterotetramer of two type I and two type II keratins.

蛋白家族:

Belongs to the intermediate filament family.

组织特异性:

Synthesis begins slightly higher in the hair shaft than HB1 and HB3 and continues much farther up, ending in the keratogeneous zone.

亚基结构:

Heterotetramer of two type I and two type II keratins.

蛋白家族:

Belongs to the intermediate filament family.

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