产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF9047, RRID:AB_2842243.
展开/折叠
ccnb2; CCNB2_HUMAN; CycB2; Cyclin B2; G2 mitotic specific cyclin B2; G2/mitotic specific cyclin B2; G2/mitotic-specific cyclin-B2; HsT17299; MGC108931; MGC140694;
抗原和靶标
- O95067 CCNB2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MALLRRPTVSSDLENIDTGVNSKVKSHVTIRRTVLEEIGNRVTTRAAQVAKKAQNTKVPVQPTKTTNVNKQLKPTASVKPVQMEKLAPKGPSPTPEDVSMKEENLCQAFSDALLCKIEDIDNEDWENPQLCSDYVKDIYQYLRQLEVLQSINPHFLDGRDINGRMRAILVDWLVQVHSKFRLLQETLYMCVGIMDRFLQVQPVSRKKLQLVGITALLLASKYEEMFSPNIEDFVYITDNAYTSSQIREMETLILKELKFELGRPLPLHFLRRASKAGEVDVEQHTLAKYLMELTLIDYDMVHYHPSKVAAAASCLSQKVLGQGKWNLKQQYYTGYTENEVLEVMQHMAKNVVKVNENLTKFIAIKNKYASSKLLKISMIPQLNSKAVKDLASPLIGRS
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - O95067 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T8 | Phosphorylation | Uniprot | |
| S10 | Phosphorylation | Uniprot | |
| S11 | Phosphorylation | Uniprot | |
| T18 | Phosphorylation | Uniprot | |
| S22 | Phosphorylation | Uniprot | |
| K23 | Ubiquitination | Uniprot | |
| K25 | Ubiquitination | Uniprot | |
| K57 | Ubiquitination | Uniprot | |
| K64 | Ubiquitination | Uniprot | |
| K73 | Ubiquitination | Uniprot | |
| S77 | Phosphorylation | Uniprot | |
| K79 | Ubiquitination | Uniprot | |
| K85 | Ubiquitination | Uniprot | |
| S92 | Phosphorylation | Uniprot | |
| T94 | Phosphorylation | Uniprot | |
| S99 | Phosphorylation | Uniprot | |
| K101 | Ubiquitination | Uniprot | |
| S204 | Phosphorylation | Uniprot | |
| S220 | Phosphorylation | Uniprot | |
| K258 | Ubiquitination | Uniprot | |
| S274 | Phosphorylation | Uniprot | |
| K275 | Ubiquitination | Uniprot | |
| Y298 | Phosphorylation | Uniprot | |
| K318 | Ubiquitination | Uniprot | |
| K324 | Ubiquitination | Uniprot | |
| K328 | Ubiquitination | Uniprot | |
| K349 | Ubiquitination | Uniprot | |
| K353 | Ubiquitination | Uniprot | |
| T359 | Phosphorylation | Uniprot | |
| K360 | Ubiquitination | Uniprot | |
| K367 | Ubiquitination | Uniprot | |
| Y368 | Phosphorylation | Uniprot | |
| K372 | Ubiquitination | Uniprot | |
| K375 | Ubiquitination | Uniprot | |
| K385 | Ubiquitination | Uniprot | |
| K388 | Ubiquitination | Uniprot | |
| S392 | Phosphorylation | Uniprot | |
| S398 | Phosphorylation | Uniprot |
研究背景
Essential for the control of the cell cycle at the G2/M (mitosis) transition.
Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex.
Belongs to the cyclin family. Cyclin AB subfamily.
研究领域
· Cellular Processes > Cell growth and death > Cell cycle. (View pathway)
· Cellular Processes > Cell growth and death > Oocyte meiosis. (View pathway)
· Cellular Processes > Cell growth and death > p53 signaling pathway. (View pathway)
· Cellular Processes > Cell growth and death > Cellular senescence. (View pathway)
· Environmental Information Processing > Signal transduction > FoxO signaling pathway. (View pathway)
· Human Diseases > Infectious diseases: Viral > HTLV-I infection.
· Organismal Systems > Endocrine system > Progesterone-mediated oocyte maturation.
限制条款
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