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| 产品: | GZMA 抗体 |
| 货号: | DF9054 |
| 描述: | Rabbit polyclonal antibody to GZMA |
| 应用: | WB |
| 反应: | Human |
| 预测: | Horse, Dog, Xenopus |
| 分子量: | 28 kDa; 29kD(Calculated). |
| 蛋白号: | P12544 |
| RRID: | AB_2842250 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF9054, RRID:AB_2842250.
展开/折叠
CTL tryptase; CTLA3; Cytolytic t cell and natural killer cell specific trypsin like serine protease; Cytotoxic T lymphocyte associated serine esterase 3; Cytotoxic T lymphocyte proteinase 1; Cytotoxic T-lymphocyte proteinase 1; Fragmentin 1; Fragmentin-1; GRAA_HUMAN; Granzyme 1 cytotoxic T lymphocyte associated serine esterase 3; Granzyme A (Cytotoxic T lymphocyte associated serine esterase 3; Hanukah factor serine protease); Granzyme A (granzyme 1, cytotoxic T lymphocyte associated serine esterase 3); Granzyme A; Granzyme A precursor; Granzyme-1; GZMA; H factor; Hanukah factor serine protease; Hanukkah factor; HF; HFSP; TSP1;
抗原和靶标
- P12544 GRAA_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MRNSYRFLASSLSVVVSLLLIPEDVCEKIIGGNEVTPHSRPYMVLLSLDRKTICAGALIAKDWVLTAAHCNLNKRSQVILGAHSITREEPTKQIMLVKKEFPYPCYDPATREGDLKLLQLMEKAKINKYVTILHLPKKGDDVKPGTMCQVAGWGRTHNSASWSDTLREVNITIIDRKVCNDRNHYNFNPVIGMNMVCAGSLRGGRDSCNGDSGSPLLCEGVFRGVTSFGLENKCGDPRGPGVYILLSKKHLNWIIMTIKGAV
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P12544 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K99 | Ubiquitination | Uniprot | |
| N170 | N-Glycosylation | Uniprot | |
| T257 | Phosphorylation | Uniprot |
研究背景
Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA.
Secreted. Cytoplasmic granule.
Homodimer; disulfide-linked. Interacts with APEX1.
Belongs to the peptidase S1 family. Granzyme subfamily.
研究领域
· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.
文献引用
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