产品: ACAA2 抗体
货号: DF9062
描述: Rabbit polyclonal antibody to ACAA2
应用: WB IHC IF/ICC
反应: Human, Rat
预测: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
分子量: 42 kDa; 42kD(Calculated).
蛋白号: P42765
RRID: AB_2842258

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   规格 价格 库存
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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产品描述

来源:
Rabbit
应用:
WB 1:1000-3000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Rat
预测:
Pig(83%), Zebrafish(83%), Bovine(92%), Horse(92%), Sheep(92%), Rabbit(92%), Dog(92%), Chicken(92%), Xenopus(83%)
克隆:
Polyclonal
特异性:
ACAA2 Antibody detects endogenous levels of total ACAA2.
RRID:
AB_2842258
引用格式: Affinity Biosciences Cat# DF9062, RRID:AB_2842258.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

3 ketoacyl CoA thiolase; 3 ketoacyl CoA thiolase mitochondrial; 3-ketoacyl-CoA thiolase, mitochondrial; 3-oxoacyl-CoA thiolase, mitochondrial; ACAA 2; Acaa2; Acetyl CoA acyltransferase 2; Acetyl CoA acyltransferase; Acetyl Coenzyme A acyltransferase 2; Acetyl-CoA acyltransferase; Beta ketothiolase; Beta-ketothiolase; DSAEC; Mitochondrial 3 oxoacyl CoA thiolase; Mitochondrial 3 oxoacyl Coenzyme A thiolase; Mitochondrial 3-oxoacyl-CoA thiolase; T1; THIM_HUMAN;

抗原和靶标

免疫原:
Uniprot:
基因/基因ID:
序列:
MALLRGVFVVAAKRTPFGAYGGLLKDFTATDLSEFAAKAALSAGKVSPETVDSVIMGNVLQSSSDAIYLARHVGLRVGIPKETPALTINRLCGSGFQSIVNGCQEICVKEAEVVLCGGTESMSQAPYCVRNVRFGTKLGSDIKLEDSLWVSLTDQHVQLPMAMTAENLAVKHKISREECDKYALQSQQRWKAANDAGYFNDEMAPIEVKTKKGKQTMQVDEHARPQTTLEQLQKLPPVFKKDGTVTAGNASGVADGAGAVIIASEDAVKKHNFTPLARIVGYFVSGCDPSIMGIGPVPAISGALKKAGLSLKDMDLVEVNEAFAPQYLAVERSLDLDISKTNVNGGAIALGHPLGGSGSRITAHLVHELRRRGGKYAVGSACIGGGQGIAVIIQSTA

种属预测

种属预测:

score>80的预测可信度较高,可尝试用于WB检测。*预测模型主要基于免疫原序列比对,结果仅作参考,不作为质保凭据。

Species
Results
Score
Horse
92
Bovine
92
Sheep
92
Dog
92
Chicken
92
Rabbit
92
Pig
83
Xenopus
83
Zebrafish
83
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - P42765 作为底物

Site PTM Type Enzyme
K13 Acetylation
Y20 Phosphorylation
K25 Acetylation
K38 Acetylation
K38 Ubiquitination
Y68 Phosphorylation
K81 Acetylation
K81 Ubiquitination
T87 Phosphorylation
T119 Phosphorylation
S121 Phosphorylation
Y127 Phosphorylation
K137 Acetylation
K137 Ubiquitination
S140 Phosphorylation
K181 Acetylation
K181 Ubiquitination
Y182 Phosphorylation
K191 Ubiquitination
Y198 Phosphorylation
K234 Acetylation
K234 Ubiquitination
K240 Acetylation
K241 Acetylation
K241 Ubiquitination
K269 Acetylation
K269 Ubiquitination
K270 Acetylation
T274 Phosphorylation
K305 Acetylation
K306 Acetylation
S310 Phosphorylation
S333 Phosphorylation
S339 Phosphorylation
R370 Methylation

研究背景

功能:

In the production of energy from fats, this is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (Probable). Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain unbranched 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms (Probable). Also catalyzes the condensation of two acetyl-CoA molecules into acetoacetyl-CoA and could be involved in the production of ketone bodies (Probable). Also displays hydrolase activity on various fatty acyl-CoAs. Thereby, could be responsible for the production of acetate in a side reaction to beta-oxidation (Probable). Abolishes BNIP3-mediated apoptosis and mitochondrial damage.

细胞定位:

Mitochondrion.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
亚基结构:

Homotetramer. Interacts with BNIP3.

蛋白家族:

Belongs to the thiolase-like superfamily. Thiolase family.

研究领域

· Metabolism > Lipid metabolism > Fatty acid elongation.

· Metabolism > Lipid metabolism > Fatty acid degradation.

· Metabolism > Amino acid metabolism > Valine, leucine and isoleucine degradation.

· Metabolism > Global and overview maps > Metabolic pathways.

· Metabolism > Global and overview maps > Fatty acid metabolism.

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