| 产品: | ORC4L 抗体 |
| 货号: | DF9086 |
| 描述: | Rabbit polyclonal antibody to ORC4L |
| 应用: | WB |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 50 kDa; 50kD(Calculated). |
| 蛋白号: | O43929 |
| RRID: | AB_2842282 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF9086, RRID:AB_2842282.
展开/折叠
;Origin recognition complex, subunit 4, S. cerevisiae, homolog of; FLJ46668; HSORC4; ORC 4; ORC 4L; ORC 4P; ORC4; ORC4_HUMAN; ORC4L; ORC4L protein; ORC4P; Origin recognition complex subunit 4 (yeast homolog) like; Origin recognition complex subunit 4; Origin recognition complex subunit 4 like (yeast); Origin recognition complex subunit 4 like; origin recognition complex, subunit 4 homolog; Origin recognition complex, subunit 4, S. cerevisiae, homolog-like;
抗原和靶标
- O43929 ORC4_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSSRKSKSNSLIHTECLSQVQRILRERFCRQSPHSNLFGVQVQYKHLSELLKRTALHGESNSVLIIGPRGSGKTMLINHALKELMEIEEVSENVLQVHLNGLLQINDKIALKEITRQLNLENVVGDKVFGSFAENLSFLLEALKKGDRTSSCPVIFILDEFDLFAHHKNQTLLYNLFDISQSAQTPIAVIGLTCRLDILELLEKRVKSRFSHRQIHLMNSFGFPQYVKIFKEQLSLPAEFPDKVFAEKWNENVQYLSEDRSVQEVLQKHFNISKNLRSLHMLLMLALNRVTASHPFMTAVDLMEASQLCSMDSKANIVHGLSVLEICLIIAMKHLNDIYEEEPFNFQMVYNEFQKFVQRKAHSVYNFEKPVVMKAFEHLQQLELIKPMERTSGNSQREYQLMKLLLDNTQIMNALQKYPNCPTDVRQWATSSLSWL
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - O43929 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S6 | Phosphorylation | Uniprot | |
| K7 | Methylation | Uniprot | |
| S10 | Phosphorylation | Uniprot | |
| S48 | Phosphorylation | Uniprot | |
| K52 | Ubiquitination | Uniprot | |
| T54 | Phosphorylation | Uniprot | |
| K112 | Ubiquitination | Uniprot | |
| K204 | Ubiquitination | Uniprot | |
| K231 | Ubiquitination | Uniprot | |
| S235 | Phosphorylation | Uniprot | |
| K243 | Ubiquitination | Uniprot | |
| K248 | Ubiquitination | Uniprot | |
| R260 | Methylation | Uniprot | |
| K268 | Ubiquitination | Uniprot | |
| K360 | Ubiquitination | Uniprot | |
| K369 | Ubiquitination | Uniprot | |
| K386 | Ubiquitination | Uniprot |
研究背景
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.
Nucleus.
Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts with DBF4 (By similarity). Interacts with POLQ.
Belongs to the ORC4 family.
研究领域
· Cellular Processes > Cell growth and death > Cell cycle. (View pathway)
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