| 产品: | ORC6L 抗体 |
| 货号: | DF9087 |
| 描述: | Rabbit polyclonal antibody to ORC6L |
| 应用: | WB |
| 反应: | Human, Mouse |
| 预测: | Pig, Bovine, Horse, Rabbit, Dog |
| 分子量: | 28 kDa; 28kD(Calculated). |
| 蛋白号: | Q9Y5N6 |
| RRID: | AB_2842283 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF9087, RRID:AB_2842283.
展开/折叠
ORC 6; Orc6; ORC6_HUMAN; ORC6L; Origin recognition complex subunit 6; origin recognition complex subunit 6 homolog like; origin recognition complex subunit 6 homolog like (yeast); origin recognition complex subunit 6 like (yeast);
抗原和靶标
- Q9Y5N6 ORC6_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGSELIGRLAPRLGLAEPDMLRKAEEYLRLSRVKCVGLSARTTETSSAVMCLDLAASWMKCPLDRAYLIKLSGLNKETYQSCLKSFECLLGLNSNIGIRDLAVQFSCIEAVNMASKILKSYESSLPQTQQVDLDLSRPLFTSAALLSACKILKLKVDKNKMVATSGVKKAIFDRLCKQLEKIGQQVDREPGDVATPPRKRKKIVVEAPAKEMEKVEEMPHKPQKDEDLTQDYEEWKRKILENAASAQKATAE
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9Y5N6 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K23 | Ubiquitination | Uniprot | |
| K34 | Ubiquitination | Uniprot | |
| R65 | Methylation | Uniprot | |
| Y67 | Phosphorylation | Uniprot | |
| K70 | Ubiquitination | Uniprot | |
| K76 | Ubiquitination | Uniprot | |
| T78 | Phosphorylation | Uniprot | |
| Y79 | Phosphorylation | Uniprot | |
| S81 | Phosphorylation | Uniprot | |
| K119 | Ubiquitination | Uniprot | |
| K168 | Acetylation | Uniprot | |
| K168 | Ubiquitination | Uniprot | |
| K177 | Ubiquitination | Uniprot | |
| K181 | Ubiquitination | Uniprot | |
| T195 | Phosphorylation | P06493 (CDK1) | Uniprot |
| K202 | Ubiquitination | Uniprot | |
| K210 | Acetylation | Uniprot | |
| K210 | Ubiquitination | Uniprot | |
| K214 | Acetylation | Uniprot | |
| K221 | Acetylation | Uniprot | |
| T229 | Phosphorylation | Uniprot | |
| Y232 | Phosphorylation | Uniprot | |
| K236 | Ubiquitination | Uniprot | |
| K238 | Ubiquitination | Uniprot | |
| S245 | Phosphorylation | Uniprot | |
| K248 | Ubiquitination | Uniprot |
研究背景
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Does not bind histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.
Nucleus.
Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts with DBF4 (By similarity).
Belongs to the ORC6 family.
研究领域
· Cellular Processes > Cell growth and death > Cell cycle. (View pathway)
限制条款
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