| 产品: | RPS10 抗体 |
| 货号: | DF9116 |
| 描述: | Rabbit polyclonal antibody to RPS10 |
| 应用: | WB |
| 反应: | Human, Mouse, Rat |
| 预测: | Zebrafish, Bovine, Horse, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 19 kDa; 19kD(Calculated). |
| 蛋白号: | P46783 |
| RRID: | AB_2842312 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF9116, RRID:AB_2842312.
展开/折叠
40S ribosomal protein S10; DBA9; MGC88819; OTTHUMP00000016229; OTTHUMP00000016230; RPS10; RS10_HUMAN; S10;
抗原和靶标
- P46783 RS10_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLMPKKNRIAIYELLFKEGVMVAKKDVHMPKHPELADKNVPNLHVMKAMQSLKSRGYVKEQFAWRHFYWYLTNEGIQYLRDYLHLPPEIVPATLRRSRPETGRPRPKGLEGERPARLTRGEADRDTYRRSAVPPGADKKAEAGAGSATEFQFRGGFGRGRGQPPQ
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P46783 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y12 | Phosphorylation | Uniprot | |
| K17 | Acetylation | Uniprot | |
| K17 | Ubiquitination | Uniprot | |
| K24 | Acetylation | Uniprot | |
| K24 | Ubiquitination | Uniprot | |
| K31 | Ubiquitination | Uniprot | |
| K38 | Acetylation | Uniprot | |
| K38 | Ubiquitination | Uniprot | |
| K47 | Ubiquitination | Uniprot | |
| K53 | Ubiquitination | Uniprot | |
| K59 | Acetylation | Uniprot | |
| K59 | Ubiquitination | Uniprot | |
| Y78 | Phosphorylation | Uniprot | |
| Y82 | Phosphorylation | Uniprot | |
| T93 | Phosphorylation | Uniprot | |
| T101 | Phosphorylation | Uniprot | |
| K107 | Sumoylation | Uniprot | |
| K107 | Ubiquitination | Uniprot | |
| T118 | Phosphorylation | Q96GD4 (AURKB) | Uniprot |
| R119 | Methylation | Uniprot | |
| T126 | Phosphorylation | Uniprot | |
| Y127 | Phosphorylation | Uniprot | |
| S130 | Phosphorylation | Uniprot | |
| K138 | Sumoylation | Uniprot | |
| K138 | Ubiquitination | Uniprot | |
| K139 | Methylation | Uniprot | |
| K139 | Sumoylation | Uniprot | |
| K139 | Ubiquitination | Uniprot | |
| S146 | Phosphorylation | Uniprot | |
| T148 | Phosphorylation | Uniprot | |
| R153 | Methylation | Uniprot | |
| R158 | Methylation | Uniprot | |
| R160 | Methylation | Uniprot |
研究背景
Component of the 40S ribosomal subunit.
Methylated by PRMT5. Methylation is necessary for its interaction with NPS1, its localization in the granular component (GC) region of the nucleolus, for the proper assembly of ribosomes, protein synthesis and optimal cell proliferation.
Monoubiquitinated by ZNF598 when a ribosome has stalled during translation of poly(A) sequences, leading to preclude synthesis of a long poly-lysine tail and initiate the ribosome quality control (RQC) pathway to degrade the potentially detrimental aberrant nascent polypeptide.
Cytoplasm. Nucleus>Nucleolus.
Note: Localized in the granular component (GC) region of the nucleolus. Methylation is required for its localization in the GC region. Colocalizes with NPS1 in the GC region of the nucleolus.
Component of the small ribosomal subunit. Interacts with PRMT5. The methylated form interacts with NPM1.
Belongs to the eukaryotic ribosomal protein eS10 family.
研究领域
· Genetic Information Processing > Translation > Ribosome.
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